This dataset presents the results from processing ribosomal RNA (rRNA)-depleted RNA-seq data derived from human brain tissues donated by individuals with and without Alzheimer disease (AD). At the individual-level, it includes data for circular and linear RNA counts as well as technical, clinical, and neuropathological phenotypes. At the summary statistic-level, it includes discovery, replication, and meta-analysis circular RNA (circRNA) differential expression and AD-trait correlation results. These results were included in the following publication: "An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations", Dube et al., 2019.
More information about the dataset is available in the README
Summary statistics data are available publically. Download Summary Statistics Data
Access to the Individual-level data and RNA-seq data is available through an approved NIAGADS application. Once approved, the dataset will be transferred via S3/FTP, as the size exceeds 1TB.
This dataset is part of the Knight ADRC Collection. Other datasets in this collection can be found at: https://www.niagads.org/knight-adrc-collection
We thank all the participants and their families, as well as the many institutions and their staff.
Funding: This work was supported by grants from the National Institutes of Health (R01AG044546, P01AG003991, RF1AG053303, R01AG058501, U01AG058922, RF1AG058501 and R01AG057777), the Alzheimer Association (NIRG-11-200110, BAND-14-338165, AARG-16-441560 and BFG-15-362540), NIH AG046374 (CMK), Tau Consortium (CMK), K23 AG049087 (JPC).
The recruitment and clinical characterization of research participants at Washington University were supported by NIH P50 AG05681, P01 AG03991, and P01 AG026276.
This work was supported by access to equipment made possible by the Hope Center for Neurological Disorders, and the Departments of Neurology and Psychiatry at Washington University School of Medicine.
The results published here are in part based on data obtained from the AMP-AD Knowledge Portal accessed via the cited accession numbers (https://www.synapse.org/#!Synapse:syn3159438).
MSBB: These data were generated from postmortem brain tissue collected through the Mount Sinai VA Medical Center Brain Bank and were provided by Eric Schadt from Mount Sinai School of Medicine.
DIAN: Data collection and sharing for this project was supported by The Dominantly Inherited Alzheimer’s Network (DIAN, UF1AG032438) funded by the National Institute on Aging (NIA), the German Center for Neurodegenerative Diseases (DZNE), Raul Carrea Institute for Neurological Research (FLENI), Partial support by the Research and Development Grants for Dementia from Japan Agency for Medical Research and Development, AMED, and the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI). This manuscript has been reviewed by DIAN Study investigators for scientific content and consistency of data interpretation with previous DIAN Study publications. We acknowledge the altruism of the participants and their families and contributions of the DIAN research and support staff at each of the participating sites for their contributions to this study.