NIAGADS GenomicsDB
The NIAGADS GenomicsDB is a searchable annotation resource that provides access to publicly available NIAGADS summary statistics datasets for Alzheimer's Disease and related neuropathologies. These data are curated along with variant and gene annotations and AD-revelant functional genomics datasets, allowing AD researchers to easily identify and interpret interesting genomic regions via interactive search strategies and the NIAGADS genome browser.
- Explore the region around a gene or SNP on the genome browser.
- Perform pathway or functional enrichment analysis on a list of genes.
- Find SNPs with genome-wide significance in NIAGADS datasets.
- Get a list of beta-amyloid binding genes.
- Explore gene-pathway memberships.
- Find SNPs associated with Alzheimer's Disease in the NHGRI GWAS Catalog.
- Upload genomic locations from a BED file to compare against curated feature annotations.
- Build your own query.
- Explore example search strategies.
September 13, 2016
- Get SNPs with genome-wide significance from NG00045: GWAS Summary Statistics for Progressive Supranuclear Palsy (PSP).
- Get SNPs with genome-wide significance from NG00049: GWAS Summary Statistics for CSF.
- Get SNPs with top genome-wide significance (p-value ≤ 5e-8) from NG00048: GWAS Summary Statistics for ADGC Age at Onset in LOAD.
April 04, 2016
- Get SNPs with top genome-wide significance (p-value ≤ 1e-3) from NG00040: GWAS summary statistics for a multi-ethnic exome array study of AD, FTD, and PSP.
- Get SNPs with top genome-wide significance (p-value ≤ 5e-8) for neurofibrillary tangles (ranked by Braak stages) from NG00041: GWAS summary statistics for Neuropathologic Features of AD and Related Dementias.
- Get FANTOM5 expressed enhancer sites within a region of interest.
- Search across ENCODE Feature tracks to find sites of transcription factor binding, histone modification, or DNAse-1 hypersensitivity within a region of interest.
Feburary 3, 2015
- Get SNPs with top genome-wide significance (p-value ≤ 1e-10) in stages 1 & 2 AD from NG00036: IGAP (2013).
- Get SNPs with top genome-wide significance (p-value ≤ 1e-10) in African Americans with genetic risk from Late-onset AD from NG00039: ADGC African Americans (2013).
- Get SNPs with top genome-wide significance (p-value ≤ 1e-10) in stages 1 & 2 adjusted for age, sex, and APOE in Late-Onset AD from NG00027: ADGC (2011).
and click each search that needs revision.