Alzheimer's Disease Genetics Consortium (ADGC) Collection

The Alzheimer's Disease Genetics Consortium is funded by a grant from the National Institute on Aging (PI, Gerard D. Schellenberg; UO1AG032984) to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD).

More information about ADGC can be found at ADGenetics.org.

ADGC GWAS Datasets From Naj et al. (2011)

Cohort Platform 1000Genomes
(Mar 2012)
Cases / Controls Total Link
Discovery (Stage 1)
ACT Illumina
Human660
Y 365 / 94 2171 NG00034
ADC1 Illumina
Human660
Y 1985 / 523 2731 NG00022
ADC2 Illumina
Human660
Y 688 / 116 926 NG00023
ADNI Illumina
Human660
NA 268 / 173 441 Access Data
GenADA Affymetrix 500 NA 669 / 713 1382 Contact PI
Genetic Differences Illumina
Human660
Y 213 / 0 213 NG00034
UMVUMSSM Illumina
Human660/
1M Duo/
Affymetrix 6.0
Y 1177 / 1123 2462 NG00042
MIRAGE Illumina
Human610/330
Y 491 / 738 1502 NG00031
NIA-LOAD Illumina 610 Y 1798 / 1568 4410 NG00032
OHSU Illumina
Human
CNV370v1_C
NA 647 647 NG00017
TGEN2 Affymetrix 6.0 Y 668 / 365 1511 NG00028
Replication (Stage 2)
ADC3 Illumina
OmniExpress
Y 843 / 430 1526 NG00024
MAYO Illumina
HumanHap300
NA 728 / 1173 2099 NG00043
ROSMAP Affymetrix 6.0 Y 294 / 763 1668 NG00029
UPitt Illumina
Human
Omni1-Quad
Y 1255 / 829 2219 NG00026
WashU Illumina
Human610
Y 259 / 186 576 NG00030

ADGC GWAS Datasets Added in Kunkle et al. (2019)

Cohort Platform 1000Genomes
(Mar 2012)
Cases / Controls Total Link
ADC4 Illumina
OmniExpress
Y 304 / 377 1054 NG00068
ADC5 Illumina
OmniExpress
Y 400 / 539 1224 NG00069
ADC6 Illumina
OmniExpress
Y 563 / 298 1333 NG00070
ADC7 Illumina
OmniExpressExome
Y 529 / 706 1462 NG00071
BIOCARD Illumina
OmniExpress
NA 6 / 112 202 Institutional
Certification
Missing
Einstein Aging Study Illumina
OmniExpress
NA 9 / 141 284 Institutional
Certification
Missing
MTC Illumina
OmniExpress
Y 256 / 189 542 NG00096
NBB Illumina1M NA 80 / 48 299 Institutional
Certification
Missing
RMAYO Illumina
OmniExpress
NA 13 / 233 428 Institutional
Certification
Missing
ROSMAP2 Illumina
OmniExpress
Y 59 / 217 544 NG00095
TARCC1 Affy 6.0 Y 323 / 181 625 NG00097
UKS Illumina 550 NA 596 / 170 1746 Institutional
Certification
Missing
WASHU2 Illumina
OmniExpress
Y 38 / 94 235 NG00087
WHICAP Illumina
OmniExpress
Y 73 / 560 653 NG00093

ADGC Exome Chip Datasets Added in Wang et al. (2015)

Cohort Platform Cases / Controls Total Link
CHOP Exome Chip Illumina
HumanExome-12
2792 / 2388 5180 NG00081
ExomeChip - WashU Illumina
HumanExome-12
519 / 349 868 NG00085
Miami Exome Chip Illumina
HumanExome-12
931 / 992 1923 NG00080
Northshore Exome Chip Illumina
HumanExome-12
3776 / 2222 5998 NG00079

 

ADGC GWAS Summary Statistics:

Dataset Link
ADGC Summary Statistics- Naj et al. (2011) NG00027
IGAP Summary Statistics- Lambert et al. (2013) NG00036
ADGC African American Summary Statistics- Reitz et al. (2013) NG00039
ADGC Neuropath Summary Stats and Phenotypes- Beecham et al. (2014) NG00041
ADGC Age at Onset Summary Statistics- Naj et al. (2014) NG00048
IGAP Summary Statistics ADGC Subset- Lambert et al. (2013) NG00053
Transethnic GWAS Summary Statistics - Jun et al. (2017) NG00056
Summary Statistics of IGAP Age at onset survival GWAS dataset - Huang KL et al. (2017) NG00058
IGAP Rare Variant Summary Statistics- Kunkle et al. (2019) NG00075
ADGC case-control summary statistics on 7050 samples not included in the IGAP-2013 discovery stage- Hu et al. (2019) NG00076
IGAP APOE-Stratified Analysis Summary Statistics- Jun et al. (2015) NG00078
GWAS Summary Statistics of informed conditioning analysis in African Americans- Mez et al. (2017) NG00088
Novel risk loci and pathways associated with Alzheimer disease in African Americans: A GWAS and meta-analysis summary statistics- Kunkle et al. (2020) NG00100