Alzheimer's Disease Genetics Consortium (ADGC) Collection
The Alzheimer's Disease Genetics Consortium is funded by a grant from the National Institute on Aging (PI, Gerard D. Schellenberg; UO1AG032984), an $18.3 million five-year research grant to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD).
More information about ADGC can be found at ADGenetics.org.
ADGC GWAS Datasets From Naj et al. (2011)
| Cohort | Platform | 1000Genomes (Mar 2012) |
Cases / Controls | Total | Link |
|---|---|---|---|---|---|
| Discovery (Stage 1) | |||||
| ACT | Illumina Human660 |
Y | 365 / 94 | 2171 | NG00034 |
| ADC1 | Illumina Human660 |
Y | 1985 / 523 | 2731 | NG00022 |
| ADC2 | Illumina Human660 |
Y | 688 / 116 | 926 | NG00023 |
| ADNI | Illumina Human660 |
NA | 268 / 173 | 441 | Access Data |
| GenADA | Affymetrix 500 | NA | 669 / 713 | 1382 | Contact PI |
| Genetic Differences | Illumina Human660 |
Y | 213 / 0 | 213 | NG00034 |
| UMVUMSSM | Illumina Human660/ 1M Duo/ Affymetrix 6.0 |
Y | 1177 / 1123 | 2462 | NG00042 |
| MIRAGE | Illumina Human610/330 |
Y | 491 / 738 | 1502 | NG00031 |
| NIA-LOAD | Illumina 610 | Y | 1798 / 1568 | 4410 | NG00032 |
| OSHU | Illumina Human CNV370v1_C |
NA | 647 | 647 | NG00017 |
| TGEN2 | Affymetrix 6.0 | Y | 668 / 365 | 1511 | NG00028 |
| Replication (Stage 2) | |||||
| ADC3 | Illumina OmniExpress |
Y | 843 / 430 | 1526 | NG00024 |
| MAYO | Illumina HumanHap300 |
NA | 728 / 1173 | 2099 | NG00043 |
| ROSMAP | Affymetrix 6.0 | Y | 294 / 763 | 1668 | NG00029 |
| UPitt | Illumina Human Omni1-Quad |
Y | 1255 / 829 | 2219 | NG00026 |
| WashU | Illumina Human610 |
Y | 259 / 186 | 576 | NG00030 |
ADGC GWAS Summary Statistics:
| Dataset | Link |
|---|---|
| ADGC Summary Statistics- Naj et al. (2011) | NG00027 |
| ADGC African American Summary Statistics- Reitz et al. (2013) | NG00039 |
| ADGC Neuropath Summary Stats and Phenotypes- Beecham et al. (2014) | NG00041 |
| ADGC Age at Onset Summary Statistics- Naj et al. (2014) | NG00048 |
| IGAP Summary Statistics ADGC Subset- Lambert et al. (2013) | NG00053 |