Alzheimer's Disease Genetics Consortium (ADGC) Collection

The Alzheimer's Disease Genetics Consortium is funded by a grant from the National Institute on Aging (PI, Gerard D. Schellenberg; UO1AG032984), an $18.3 million five-year research grant to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD).

More information about ADGC can be found at ADGenetics.org.

ADGC GWAS Datasets From Naj et al. (2011)

Cohort Platform HapMap2 1000Genomes (Dec 2010) Cases / Controls Link
Discovery (Stage 1)
ACT Illumina
Human660
Y Y 354 / 1981 NG00034
ADC1 Illumina
Human660
Y Y 1566 / 515 NG00022
ADC2 Illumina
Human660
Y Y 738 / 160 NG00023
ADNI Illumina
Human660
NA NA 268 / 173 Access Data
GenADA Affymetrix 500 NA NA 669 / 713 Contact PI
Genetic Differences Illumina
Human660
Y Y 213 / 0 NG00034
UMVUMSSM Illumina
Human660/
1M Duo/
Affymetrix 6.0
Y Y 1177 / 1126 NG00042
MIRAGE Illumina
Human610/330
NA Y 509 / 753 NG00031
NIA-LOAD Illumina 610 Y Y 1852 / 1991 NG00032
OSHU Illumina
Human
CNV370v1_C
Y Y 647 NG00017
TGEN2 Affymetrix 6.0 Y Y 864 / 493 NG00028
Replication (Stage 2)
ADC3 Illumina
OmniExpress
Y Y 897 / 588 NG00024
MAYO Illumina
HumanHap300
Y Y 728 / 1173 NG00043
ROSMAP Affymetrix 6.0 Y Y 296 / 776 NG00029
UPitt Illumina
Human
Omni1-Quad
Y Y 1440 / 1000 NG00026
WashU Illumina
Human610
Y Y 403 / 225 NG00030

ADGC GWAS Summary Statistics:

Dataset Link
ADGC Summary Statistics- Naj et al. (2011) NG00027
ADGC African American Summary Statistics- Reitz et al. (2013) NG00039
ADGC Neuropath Summary Stats and Phenotypes- Beecham et al. (2014) NG00041
ADGC Age at Onset Summary Statistics- Naj et al. (2014) NG00048
IGAP Summary Statistics ADGC Subset- Lambert et al. (2013) NG00053