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Circular RNA expression and function in the brain.

TitleCircular RNA expression and function in the brain.
Publication TypeJournal Article
Year of Publication2019
AuthorsSekar, S, Liang, WS
JournalNoncoding RNA Res
Date Published2019 Mar

Within the last decade, active research on circular RNAs (circRNAs) has dramatically improved our understanding of the expression and function of these non-coding RNAs. While several mechanisms for circRNA function have been proposed, including sequestration of microRNAs and regulation of cellular proteins, studies provide evidence that circRNAs can regulate transcription and may also serve as biomarkers. Due to the heterogeneous nature of the brain, and the dynamic transcriptional mechanisms that support neurobiological pathways, the influence of circRNAs is potentially extensive. Understanding how circRNAs contribute to key neurological pathways will fill gaps in our understanding of brain function and provide valuable insight into novel therapeutic approaches to treat neurological diseases. Here, we review recent research on circRNA expression in the brain, describe the proposed functions of circRNAs, and evaluate the role of circRNAs in neurological diseases.

Alternate JournalNoncoding RNA Res
PubMed ID30891534
PubMed Central IDPMC6404376
Grant ListP30 AG019610 / AG / NIA NIH HHS / United States