The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.

TitleThe Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease.
Publication TypeJournal Article
Year of Publication2018
AuthorsWang M, Beckmann ND, Roussos P, Wang E, Zhou X, Wang Q, Ming C, Neff R, Ma W, Fullard JF, Hauberg ME, Bendl J, Peters MA, Logsdon B, Wang P, Mahajan M, Mangravite LM, Dammer EB, Duong DM, Lah JJ, Seyfried NT, Levey AI, Buxbaum JD, Ehrlich M, Gandy S, Katsel P, Haroutunian V, Schadt E, Zhang B
JournalSci Data
Volume5
Pagination180185
Date Published2018 09 11
ISSN2052-4463
KeywordsAged, 80 and over, Alzheimer Disease, Cognitive Dysfunction, Cohort Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Genomics, Humans, Proteome, Proteomics, Transcriptome
Abstract

Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally fatal following an average course of 10 years of progressive cognitive disability. Genetic and genome-wide association studies (GWAS) have identified about 33 risk factor genes for common, late-onset AD (LOAD), but these risk loci fail to account for the majority of affected cases and can neither provide clinically meaningful prediction of development of AD nor offer actionable mechanisms. This cohort study generated large-scale matched multi-Omics data in AD and control brains for exploring novel molecular underpinnings of AD. Specifically, we generated whole genome sequencing, whole exome sequencing, transcriptome sequencing and proteome profiling data from multiple regions of 364 postmortem control, mild cognitive impaired (MCI) and AD brains with rich clinical and pathophysiological data. All the data went through rigorous quality control. Both the raw and processed data are publicly available through the Synapse software platform.

DOI10.1038/sdata.2018.185
Alternate JournalSci Data
PubMed ID30204156
PubMed Central IDPMC6132187
Grant ListR01 AG050986 / AG / NIA NIH HHS / United States
RF1 AG057440 / AG / NIA NIH HHS / United States
RF1 AG054014 / AG / NIA NIH HHS / United States
U01 AG046170 / AG / NIA NIH HHS / United States
R01 AG057907 / AG / NIA NIH HHS / United States
S10 OD018522 / OD / NIH HHS / United States
HHSN271201300031C / MH / NIMH NIH HHS / United States