News

The Alzheimer’s Disease Genetics Global Symposium starts tomorrow 9/1. Registration is free ! To learn more go to the symposium web page .
The NIA is excited to announce the release of the latest genomics dataset from the Alzheimer’s Disease Sequencing Project (ADSP) . The NIA Genetics of Alzheimer’s Disease Data Storage Site (NIAGADS) is a vital tool as we seek to better understand genes that increase risk for — or protection from — AD/ADRD. Researchers can now access new, robust ADSP sequencing of nearly 20,000 samples from 9 different studies so they can continue their Alzheimer’s disease research from home. Read the full blog post at Inside NIA: A Blog for Researchers .
NIAGADS is pleased to announce the release of 19,922 whole exomes called on GRCh38 through the Data Sharing Service (DSS) . Nine different studies contributed to the release, including 10,088 ADSP Discovery Case Control WES samples, 3,144 ADGC African American WES samples, 75 Brkanac Families WES samples, 346 Corticobasal degeneration WES samples, 3,861 Columbia WHICAP WES samples, 1,100 FASe Families WES samples, 650 Knight ADRC WES samples, 108 Miami Families WES samples, and 550 Progressive supranuclear palsy WES samples. These data were called by the Genome Center for Alzheimer’s Disease...
NIAGADS is pleased to announce that the Genomics Database v.3.4 has now been released. This release makes available ~50K new small INDELS identified by the ADSP whole-exome sequencing project and annotated by the ADSP Annotation Working Group. Also newly available are two new summary statistics datasets: NG00065 (SVs): summary statistics for ~1.5 million single nucleotide variants (SNVs) and 50,000 insertion-deletion polymorphisms (indels) identified by the ADSP whole-exome sequencing project and tested for association to AD NG00058: summary statistics from a genome-wide survival analysis of...
NIAGADS is pleased to announce that the Genomics Database v. 3.3 has been released. It includes three new datasets: NG00065 (ADSP Case/Control): Gene level evidence for Alzheimer’s Disease from the ADSP Case/Control Work Group is now available. NG00061 (Functional Annotation of genomic variants in studies of LOAD): ADSP Discovery Phase whole genome and whole exome sequenced single nucleotide variants are now available. ExAC allele frequencies, CADD deleteriousness scores, and CATO transcription factor binding overlap variant annotations have also been added. NG00052 (CLU, A potential...
NIAGADS is pleased to announce that its Data Sharing Service (DSS) is now live. The NIAGADS DSS hosts genomic data from the Alzheimer’s Disease Sequencing Project (ADSP) and other NIA funded AD genomic studies with approved users in the research community at large. The DSS hosts sequencing data mapped to GRCh38, while ADSP Discovery data mapped to GRCh37 can still be accessed at dbGaP. If you are a Principal Investigator interested in accessing data, we encourage you to take a look at the application guidelines .