Description
Data Available
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00068) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
This GWAS dataset, ADC4, is the fouth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone ADGC quality control procedures, imputation files (.bgen format) run through the TOPMED r2 pipeline, as well as basic phenotypes as provided by the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) derived from data provided by the National Alzheimer’s Coordinating Center (NACC). Additional phenotypic data are available for request through NACC. The ADSP-PHC has harmonized additional domains for the NACC participants and for more information about available data and where to request access, visit the ADSP data page (ng00067).
Sample Summary per Data Type
Sample Set | Accession | Data Type | Number of Samples |
---|---|---|---|
ADGC ADC Round 4 | snd10061 | Genotyping SNP Array | 1054 |
Available Filesets
Name | Accession | Latest Release | Description |
---|---|---|---|
ADGC ADC Round 4: GWAS, TOPMed Imputation, Phenotype files | fsa000076 | NG00068.v1 | GWAS, TOPMed Imputation, Phenotype files |
View the File Manifest for a full list of files released in this dataset.
Subject Information
The ADC4 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_H) beadchip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer's Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011) was applied to this GWAS dataset.
Sample Set | Accession Number | Number of Subjects |
---|---|---|
ADGC ADC Round 4 | snd10061 | 1054 |
Related Studies
Consent Levels
Consent Level | Number of Subjects |
---|---|
DS-ADRD-IRB-PUB | 162 |
DS-ADRDAGE-IRB-PUB | 106 |
DS-ADRDMEM-IRB-PUB-NPU | 2 |
DS-ND-IRB-PUB | 89 |
DS-ND-IRB-PUB-MDS | 4 |
DS-ND-IRB-PUB-NPU | 5 |
DS-NEURO-IRB-PUB-NPU | 21 |
GRU-IRB-PUB | 565 |
GRU-IRB-PUB-NPU | 3 |
HMB-IRB-PUB | 80 |
HMB-IRB-PUB-MDS | 17 |
Visit the Data Use Limitations page for definitions of the consent levels above.