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Within the application, add this dataset (accession NG00068) in the “Choose a Dataset” section.
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Description

This GWAS dataset, ADC4, is the fouth set of ADC genotyped subjects used by the Alzheimer’s Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing Alzheimer’s disease. Provided here, are the PLINK genotype files that have undergone ADGC quality control procedures, imputation files (.bgen format) run through the TOPMED r2 pipeline, as well as basic phenotypes as provided by the Alzheimer’s Disease Sequencing Project Phenotype Harmonization Consortium (ADSP-PHC) derived from data provided by the National Alzheimer’s Coordinating Center (NACC). Additional phenotypic data are available for request through NACC. The ADSP-PHC has harmonized additional domains for the NACC participants and for more information about available data and where to request access, visit the ADSP data page (ng00067).

Sample Summary per Data Type

Sample SetAccessionData TypeNumber of Samples
ADGC ADC Round 4snd10061Genotyping SNP Array1054

Available Filesets

NameAccessionLatest ReleaseDescription
ADGC ADC Round 4: GWAS, TOPMed Imputation, Phenotype filesfsa000076NG00068.v1GWAS, TOPMed Imputation, Phenotype files

View the File Manifest for a full list of files released in this dataset.

The ADC4 sample set was genotyped by the Center for Applied Genomics at the Children's Hospital of Philadelphia using the Illumina Human OmniExpress (HumanOmniExpress-12v1_H) beadchip which captures genotype data on 730,525 genomic SNPs. The standard Alzheimer's Disease Genetics Consortium (ADGC) quality control pipeline (Naj et al. 2011) was applied to this GWAS dataset.

Sample SetAccession NumberNumber of Subjects
ADGC ADC Round 4snd100611054
Consent LevelNumber of Subjects
DS-ADRD-IRB-PUB162
DS-ADRDAGE-IRB-PUB106
DS-ADRDMEM-IRB-PUB-NPU2
DS-ND-IRB-PUB89
DS-ND-IRB-PUB-MDS4
DS-ND-IRB-PUB-NPU5
DS-NEURO-IRB-PUB-NPU21
GRU-IRB-PUB565
GRU-IRB-PUB-NPU3
HMB-IRB-PUB80
HMB-IRB-PUB-MDS17

Visit the Data Use Limitations page for definitions of the consent levels above.