Summary statistics of genome wide association study to identify genetic modifiers of CSF sTREM2 (Soluble triggering receptor expressed on myeloid cells 2) obtained using ADNI samples. Alzheimer’s Disease Neuroimaging Initiative (ADNI) samples (n=813), are the largest dataset for CSF sTREM2 samples to date. The analyzed dataset included samples from 172 AD, 169 cognitively normal, 183 early mild cognitive impairment (EMCI), 221 late MCI (LMCI), and 68 significant memory concern (SMC) individuals.
The p-value data is generally available to all users using the link below; however, gaining access to the complete dataset requires a formal data request.
This dataset is part of the Knight ADRC Collection. Other datasets in this collection can be found at: https://www.niagads.org/knight-adrc-collection
This work was supported by grants from the NIH [R01AG044546 (to C.C.), P01AG003991 (to C. Cruchaga), RF1AG053303 (to C. Cruchaga), RF1AG058501 (to C. Cruchaga), U01AG058922 (to C. Cruchaga), K01AG046374 (to C.M.K.), and R01HL119813 (to T.J.B.)]. C. Cruchaga was also supported by the Alzheimer’s Association (NIRG-11-200110, BAND-14-338165, AARG-16-441560, and BFG-15-362540). Y.D. was supported by an NIMH institutional training grant (T32MH014877). L.P. was supported by a grant from the Fondazione Italiana Sclerosi Multipla (FISM 2017/R/20). F.F. was supported by a Fondazione Veronesi fellowship. C. Cantoni was supported during the course of this study by a fellowship from the National Multiple Sclerosis Society (FG 2010-A1/2). B.A.B. is supported by 2018 pilot funding from the Hope Center for Neurological Disorders and the Danforth Foundation Challenge at Washington University. The recruitment and clinical characterization of research participants at Washington University was supported by NIH P50 AG05681, P01 AG03991, and P01 AG026276