Urokinase-Type Plasminogen Activator
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
Risk Factors
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Polymorphism, Single Nucleotide
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Polymorphism, Genetic
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
Male
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Linkage Disequilibrium
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Insulysin
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Humans
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Haplotypes
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Genotype
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Genetic Markers
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Genetic Linkage
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
Gene Frequency
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Female
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
Chromosomes, Human, Pair 10
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
Case-Control Studies
A. J. Myers, Marshall, H., Holmans, P., Compton, D., Crook, R. J. P., Mander, A. P., Nowotny, P., Smemo, S., Dunstan, M., Jehu, L., Wang, J. C., Hamshere, M., Morris, J. C., Norton, J., Chakraventy, S., Tunstall, N., Lovestone, S., Petersen, R., O'Donovan, M., Jones, L., Williams, J., Owen, M. J., Hardy, J., and Goate, A.,
“Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 124B, no. 1, pp. 29-37, 2004.
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Apolipoproteins E
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.
Alzheimer Disease
P. Nowotny, Hinrichs, A. L., Smemo, S., Kauwe, J. S. K., Maxwell, T., Holmans, P., Hamshere, M., Turic, D., Jehu, L., Hollingworth, P., Moore, P., Bryden, L., Myers, A., Doil, L. M., Tacey, K. M., Gibson, A. M., McKeith, I. G., Perry, R. H., Morris, C. M., Thal, L., Morris, J. C., O'Donovan, M. C., Lovestone, S., Grupe, A., Hardy, J., Owen, M. J., Williams, J., and Goate, A.,
“Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme.”,
Am J Med Genet B Neuropsychiatr Genet, vol. 136B, no. 1, pp. 62-8, 2005.