Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
| Title | Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Myers, AJ, Marshall, H, Holmans, P, Compton, D, Crook, RJP, Mander, AP, Nowotny, P, Smemo, S, Dunstan, M, Jehu, L, Wang, JC, Hamshere, M, Morris, JC, Norton, J, Chakraventy, S, Tunstall, N, Lovestone, S, Petersen, R, O'Donovan, M, Jones, L, Williams, J, Owen, MJ, Hardy, J, Goate, A |
| Journal | Am J Med Genet B Neuropsychiatr Genet |
| Volume | 124B |
| Issue | 1 |
| Pagination | 29-37 |
| Date Published | 2004 Jan 01 |
| ISSN | 1552-4841 |
| Keywords | Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Case-Control Studies, Chromosomes, Human, Pair 10, Female, Gene Frequency, Genetic Linkage, Genotype, Haplotypes, Humans, Male, Polymorphism, Genetic, Urokinase-Type Plasminogen Activator |
| Abstract | Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data. |
| DOI | 10.1002/ajmg.b.20036 |
| Alternate Journal | Am. J. Med. Genet. B Neuropsychiatr. Genet. |
| PubMed ID | 14681909 |
| Grant List | U24 AG021886 / AG / NIA NIH HHS / United States AG5681 / AG / NIA NIH HHS / United States AG 16574 / AG / NIA NIH HHS / United States AG 06786 / AG / NIA NIH HHS / United States AG16208 / AG / NIA NIH HHS / United States |