Variation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.

TitleVariation in the urokinase-plasminogen activator gene does not explain the chromosome 10 linkage signal for late onset AD.
Publication TypeJournal Article
Year of Publication2004
AuthorsMyers AJ, Marshall H, Holmans P, Compton D, Crook RJP, Mander AP, Nowotny P, Smemo S, Dunstan M, Jehu L, Wang JC, Hamshere M, Morris JC, Norton J, Chakraventy S, Tunstall N, Lovestone S, Petersen R, O'Donovan M, Jones L, Williams J, Owen MJ, Hardy J, Goate A
JournalAm J Med Genet B Neuropsychiatr Genet
Volume124B
Issue1
Pagination29-37
Date Published2004 Jan 01
ISSN1552-4841
KeywordsAged, Aged, 80 and over, Alleles, Alzheimer Disease, Case-Control Studies, Chromosomes, Human, Pair 10, Female, Gene Frequency, Genetic Linkage, Genotype, Haplotypes, Humans, Male, Polymorphism, Genetic, Urokinase-Type Plasminogen Activator
Abstract

Linkage studies indicate that the same region of chromosome 10 contains a risk locus for late onset Alzheimer disease (LOAD) and a QTL for plasma Abeta42 levels suggesting that a single locus may influence risk for AD by elevating plasma Abeta42 [Ertekin-Taner et al., 2000; Myers et al., 2000]. A strong positional and biological candidate is the urokinase-plasminogen activator (PLAU) gene. Eight polymorphisms spanning the entire gene were examined using case control (CC) and family-based association methods. No association was observed by any method making it unlikely that variation in PLAU explains our linkage data.

DOI10.1002/ajmg.b.20036
Alternate JournalAm. J. Med. Genet. B Neuropsychiatr. Genet.
PubMed ID14681909
Grant ListU24 AG021886 / AG / NIA NIH HHS / United States
AG5681 / AG / NIA NIH HHS / United States
AG 16574 / AG / NIA NIH HHS / United States
AG 06786 / AG / NIA NIH HHS / United States
AG16208 / AG / NIA NIH HHS / United States