Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease.
| Title | Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. |
| Publication Type | Journal Article |
| Year of Publication | 2006 |
| Authors | Smemo, S, Nowotny, P, Hinrichs, AL, Kauwe, JSK, Cherny, S, Erickson, K, Myers, AJ, Kaleem, M, Marlowe, L, Gibson, AM, Hollingworth, P, O'Donovan, MC, Morris, CM, Holmans, P, Lovestone, S, Morris, JC, Thal, L, Li, Y, Grupe, A, Hardy, J, Owen, MJ, Williams, J, Goate, A |
| Journal | Ann Neurol |
| Volume | 59 |
| Issue | 1 |
| Pagination | 21-6 |
| Date Published | 2006 Jan |
| ISSN | 0364-5134 |
| Keywords | Alzheimer Disease, Carrier Proteins, Cell Cycle Proteins, Female, Genotype, Haplotypes, Humans, Linkage Disequilibrium, Middle Aged, Polymorphism, Genetic, Risk Factors |
| Abstract | Several studies have reported evidence for linkage of late-onset Alzheimer's disease (LOAD) to chromosome 9. Recently, an intronic polymorphism affecting alternative splicing of exon 8 of ubiquilin 1 (UBQLN1) was reported to be associated with LOAD. We attempted to replicate this observation by genotyping this polymorphism, rs12344615 (also known as UBQ-8i), in a large sample of 1,544 LOAD cases and 1,642 nondemented controls. We did not find any evidence that this single nucleotide polymorphism, or any of six others tested in UBQLN1, increases risk for LOAD. |
| DOI | 10.1002/ana.20673 |
| Alternate Journal | Ann. Neurol. |
| PubMed ID | 16278862 |
| Grant List | P50 AG 05681 / AG / NIA NIH HHS / United States P50 AG 05131 / AG / NIA NIH HHS / United States AG 16208 / AG / NIA NIH HHS / United States G0701075 / / Medical Research Council / United Kingdom G0300429 / / Medical Research Council / United Kingdom P01 AG 03991 / AG / NIA NIH HHS / United States G9810900 / / Medical Research Council / United Kingdom |