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Overview and findings from the religious orders study.

TitleOverview and findings from the religious orders study.
Publication TypeJournal Article
Year of Publication2012
AuthorsBennett, DA, Schneider, JA, Arvanitakis, Z, Wilson, RS
JournalCurr Alzheimer Res
Volume9
Issue6
Pagination628-45
Date Published2012 Jul
ISSN1875-5828
KeywordsAged, Aged, 80 and over, Aging, Alzheimer Disease, Autopsy, Brain, Epidemiologic Studies, Female, Humans, Longitudinal Studies, Male, Neuropsychological Tests, Research Design, Risk Factors
Abstract

UNLABELLED: The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer's disease (AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation, assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem data.

THE RESULTS: (1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate to death; (2) examine the relation of risk factors to clinical outcomes; (3) examine the relation of risk factors to measures of neuropathology; and (4) summarize additional study findings. We then discuss and contextualize the study findings.

Alternate JournalCurr Alzheimer Res
PubMed ID22471860
PubMed Central IDPMC3409291
Grant ListR01AG24871 / AG / NIA NIH HHS / United States
R01 AG024871 / AG / NIA NIH HHS / United States
P01AG14449 / AG / NIA NIH HHS / United States
K08AG00849 / AG / NIA NIH HHS / United States
K08 AG000849 / AG / NIA NIH HHS / United States
R01AG26916 / AG / NIA NIH HHS / United States
R01 AG043375 / AG / NIA NIH HHS / United States
P01 AG009466 / AG / NIA NIH HHS / United States
R01AG26147 / AG / NIA NIH HHS / United States
P30 AG010161 / AG / NIA NIH HHS / United States
P01 AG014449 / AG / NIA NIH HHS / United States
P01AG09466 / AG / NIA NIH HHS / United States
R01 AG026147 / AG / NIA NIH HHS / United States
R01AG15819 / AG / NIA NIH HHS / United States
P30AG10161 / AG / NIA NIH HHS / United States
R01 AG026916 / AG / NIA NIH HHS / United States
K23 AG023675 / AG / NIA NIH HHS / United States
R01 AG015819 / AG / NIA NIH HHS / United States
K23AG23675 / AG / NIA NIH HHS / United States