We’re moving! Datasets in the NIAGADS database are being transitioned to the DSS database, click to learn more.

Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.

TitleGenetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals.
Publication TypeJournal Article
Year of Publication2014
AuthorsBarral, S, Reitz, C, Small, SA, Mayeux, R
JournalNeurobiol Aging
Volume35
Issue12
Pagination2881.e7-2881.e10
Date Published2014 Dec
ISSN1558-1497
KeywordsAcetylation, Aging, Cognition, Cohort Studies, CREB-Binding Protein, Cyclic AMP Response Element-Binding Protein, Genetic Association Studies, Histones, Humans, Memory, Memory, Episodic, Polymorphism, Single Nucleotide, Retinoblastoma-Binding Protein 4
Abstract

The molecular pathways underlying age-related memory changes remain unclear. There is a substantial genetic contribution to memory performance through life span. A recent study has implicated RbAp48, which mediates its effect on age-related memory decline by interacting with cyclic adenosine monophosphate responsive element binding protein (CREB)1 binding protein and influencing this histone acetylation pathway. To validate these findings, we tested whether genetic variants in RbAp48, CREB1, and CREBBP are associated with memory performance in 3 independent data sets consisting of 2674 cognitively healthy elderly individuals. Genetic variant rs2526690 in the CREBBP gene was significantly associated with episodic memory performance (pmeta = 3.7 × 10(-4)) in a multivariate model adjusted for age, sex, and apolipoprotein E status. Identifying genetic variants that modulate mechanisms of cognitive aging will allow identifying valid targets for therapeutic intervention.

DOI10.1016/j.neurobiolaging.2014.06.024
Alternate JournalNeurobiol. Aging
PubMed ID25150575
PubMed Central IDPMC4253058
Grant ListU01-AG032984 / AG / NIA NIH HHS / United States
U24 AG021886 / AG / NIA NIH HHS / United States
U24-AG026395 / AG / NIA NIH HHS / United States
U01 AG032984 / AG / NIA NIH HHS / United States
U01 AG016976 / AG / NIA NIH HHS / United States
P01 AG007232 / AG / NIA NIH HHS / United States
U24-AG21886 / AG / NIA NIH HHS / United States
U24 AG026395 / AG / NIA NIH HHS / United States
R01 AG041797 / AG / NIA NIH HHS / United States
R01-AG037212 / AG / NIA NIH HHS / United States
R01-AG041797 / AG / NIA NIH HHS / United States
R01 AG037212 / AG / NIA NIH HHS / United States
P01-AG007232 / AG / NIA NIH HHS / United States
U01-AG016976 / AG / NIA NIH HHS / United States