Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities.

TitleGenetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities.
Publication TypeJournal Article
Year of Publication2015
AuthorsReitz C
JournalExpert Rev Mol Diagn
Volume15
Issue3
Pagination339-48
Date Published2015 Mar
ISSN1744-8352
KeywordsAlzheimer Disease, Biomarkers, Computational Biology, Genetic Predisposition to Disease, Genetic Testing, Genome-Wide Association Study, Genomics, Humans, Prognosis
Abstract

Alzheimer's disease (AD), the most common form of dementia in western societies, is a pathologically and clinically heterogeneous disease with a strong genetic component. The recent advances in high-throughput genome technologies allowing for the rapid analysis of millions of polymorphisms in thousands of subjects has significantly advanced our understanding of the genomic underpinnings of AD susceptibility. During the last 5 years, genome-wide association and whole-exome- and whole-genome sequencing studies have mapped more than 20 disease-associated loci, providing insights into the molecular pathways involved in AD pathogenesis and hinting at potential novel therapeutic targets. This review article summarizes the challenges and opportunities of when using genomic information for the diagnosis and prognosis of AD.

DOI10.1586/14737159.2015.1002469
Alternate JournalExpert Rev. Mol. Diagn.
PubMed ID25634383
PubMed Central IDPMC4677675
Grant ListK23 AG034550 / AG / NIA NIH HHS / United States
K23AG034550 / AG / NIA NIH HHS / United States