Exceptional memory performance in the Long Life Family Study.
Title | Exceptional memory performance in the Long Life Family Study. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Barral, S, Cosentino, S, Costa, R, Andersen, SL, Christensen, K, Eckfeldt, JH, Newman, AB, Perls, TT, Province, MA, Hadley, EC, Rossi, WK, Mayeux, R |
Corporate Authors | Long Life Family Study |
Journal | Neurobiol Aging |
Volume | 34 |
Issue | 11 |
Pagination | 2445-8 |
Date Published | 2013 Nov |
ISSN | 1558-1497 |
Keywords | Aged, 80 and over, Family Health, Female, Humans, Longevity, Male, Memory, Episodic, Phenotype |
Abstract | Research to understand variability at the highest end of the cognitive performance distribution has been scarce. Our aim was to define a cognitive endophenotype based on exceptional episodic memory (EM) performance and to investigate familial aggregation of EM in families from the Long Life Family Study (LLFS). Using a sample of 1911 nondemented offspring of long-lived probands, we created a quantitative phenotype, EM (memory z ≥ 1.5), and classified LLFS families as EM and non-EM families based on the number of EM offspring. We then assessed differences in memory performance between LLFS relatives in the parental generation of EM families and those in non-EM families using multivariate analysis adjusted for APOE Apolipoprotein E genotype. LLFS relatives in the proband generation from EM families showed better EM performance than those from non-EM families (β = 0.74, standard error = 0.19, p = 1.4 × 10(-4)). We demonstrated that there is a familial correlation of the EM endophenotype, suggesting that genetic variants might influence memory performance in long-lived families. |
DOI | 10.1016/j.neurobiolaging.2013.05.002 |
Alternate Journal | Neurobiol. Aging |
PubMed ID | 23759147 |
PubMed Central ID | PMC4095822 |
Grant List | U01 AG023712 / AG / NIA NIH HHS / United States U01 AG023744 / AG / NIA NIH HHS / United States U24 AG021886 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States P30 AG034424 / AG / NIA NIH HHS / United States P01AG08761 / AG / NIA NIH HHS / United States U01 AG023749 / AG / NIA NIH HHS / United States U01-AG023712 / AG / NIA NIH HHS / United States U01 AG023755 / AG / NIA NIH HHS / United States P01 AG008761 / AG / NIA NIH HHS / United States U01 AG023746 / AG / NIA NIH HHS / United States U01-AG23744 / AG / NIA NIH HHS / United States U01-AG023755 / AG / NIA NIH HHS / United States U01-AG023746 / AG / NIA NIH HHS / United States U01-AG023749 / AG / NIA NIH HHS / United States |