NG00097 - TARCC GWAS

The Texas Alzheimer’s Research Care Consortium (TARCC) is a collaborative Alzheimer’s research effort directed and funded by the Texas Council on Alzheimer’s Disease and Related Disorders (the Council), as part of the Darrell K Royal Texas Alzheimer’s Initiative. Composed of Baylor College of Medicine (BCM), Texas Tech University Health Sciences Center (TTUHSC), University of North Texas Health Science Center (UNTHSC), the UT Southwestern Medical Center at Dallas (UTSW), University of Texas Health Science Center at San Antonio (UTHSCSA), Texas A&M Health Science Center (TAMHSC), and the University of Texas at Austin (UTA), this consortium was created to establish a comprehensive research cohort of well characterized subjects to address better diagnosis, treatment, and ultimately prevention of Alzheimer’s disease. The resulting prospective cohort, the Texas Harris Alzheimer's Research Study, contains clinical, neuropsychiatric, genetic, and blood biomarker data on more than 3,000 participants diagnosed with Alzheimer's disease, mild cognitive impairment (MCI), and cognitively normal individuals. Longitudinal data/sample collection and follow-up on participants occurs on an annual basis.

Two waves of case-control data from TARCC were examined as part of genetic analyses in the ADGC. Data from the TARCC included 323 cases and 181 controls in the first wave (included in the TARCC1 cohort), with 84 cases and 115 controls in the second wave (included in the MTC cohort). All TARCC subjects were greater than 65 years of age at disease onset (cases) or at last disease-free exam (non-cases).

Detailed information about the dataset is provided in the following document: NG00097_TARCC_README.txt