NG00095 - ROSMAP2 GWAS

ROS (Religious Orders Study) ad MAP (Memory and Aging Project) are two community-based cohort studies.

The ROS has been ongoing since 1993, with a rolling admission. Through July of 2010, 1,139 older nuns, priests, and brothers from across the United States initially free of dementia who agreed to annual clinical evaluation and brain donation at the time of death completed their baseline evaluation.

The MAP has been on-going since 1997, also with a rolling admission. Through July of 2010, 1,356 older persons from across northeastern Illinois initially free of dementia who agreed to annual clinical evaluation and organ donation at the time of death completed their baseline evaluation. Details of the clinical and neuropathologic evaluations have been previously reported. A total of 1,064 persons passed genotyping QC. Of these, 295 met clinical criteria for Alzheimer’s disease at the time of their last clinical evaluation or time of death and met neuropathologic criteria for Alzheimer’s disease for those on whom neuropathologic data were available, and 769 were without dementia or MCI at the time of their last clinical evaluation or time of death and did not meet neuropathologic criteria for Alzheimer’s disease for those on whom neuropathologic data were available. A second wave of ROSMAP (referred to as ROSMAP2 in this study included 59 persons who met clinical criteria for Alzheimer’s disease at the time of their last clinical evaluation or time of death and met neuropathologic criteria for Alzheimer’s disease for those on whom neuropathologic data were available, and 217 persons who were without dementia or MCI at the time of their last clinical evaluation or time of death and did not meet neuropathologic criteria for Alzheimer’s disease for those on whom neuropathologic data were available.

Detailed information about the dataset is provided in the following document: NG00095_ROSMAP2_README.txt