Dataset

NG00078 - IGAP APOE-Stratified Analysis Summary Statistics- Jun et al. (2015)

Overview

This dataset contains the genome-wide association study (GWAS) meta-analysis results for the discovery (stage 1) presented in (Jun et al. 2015). A set of GWAS meta-analyses for AD status was performed in four models: 1) using all sample; 2) using APOE e4 carriers; 3) using APOE e4 non-carriers; and 4) interaction test with APOE e4 status. The total of 53,711 subjects for the meta-analysis at the stage 1 were assembled by International Genomics Alzheimer 's Project (IGAP) from the Alzheimer’s Disease Genetic Consortium (ADGC), the Cohorts for Heart and Ageing Research in Genomic Epidemiology (CHARGE) consortium, the European Alzheimer's Disease Initiative (EADI) and the Genetic and Environmental Risk in Alzheimer’s Disease (GERAD) consortium. The detail information for sample recruitment, genotyping, imputation, QC, etc. has been reported previously (Jun et al. 2015).

GWAS was performed separately in each study. The additive genetic effect of each SNP after imputation was estimated using regression analysis adjusting for age, sex, and principal components for population structures. SNP effect estimates and their SEs were combined by a fixed effect model with inverse variance weighted method using the METAL software for each model. After the meta-analysis, the SNPs with avaiable estimates at least half number of data sets are reported. Only the SNPs that attained suggestively significant association level (P<1e-5) were tested in the stage 2 using additional ADGC datasets, which have been reported in the Supplementary Table of the paper above (Jun et al. 2015).

The p-value data is available to all users using the link below; however, gaining access to the complete dataset requires a formal data request.

Summary Statistics p-values only

Molecular Data Type

Disease

AD
Submission date: 
1/28/2019
PI Information