Cerebrospinal fluid (CSF) tau, tau phosphorylated at threonine 181 (ptau), and Aβ₄₂ are established biomarkers for Alzheimer's disease (AD) and have been used as quantitative traits for genetic analyses. This is the largest genome-wide association study for cerebrospinal fluid (CSF) tau/ptau levels published to date (n >3000), and identified three genome-wide hits for CSF Aβ₄₂ and five loci for ptau levels.
The p-value data is generally available to all users using the link below; however, gaining access to the complete dataset requires a formal data request.
This work was supported by grants from the National Institutes of Health (R01AG044546, P01AG003991, RF1AG053303, R01AG035083, and R01NS085419), and the Alzheimer’s Association (NIRG-11-200110). The recruitment and clinical characterization of research participants at Washington University were supported by NIH P50 AG05681, P01 AG03991, and P01 AG026276.
People using this dataset should also cite the original manuscript: Deming et al., Acta Neuropathol 2017.