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The African American participants that were included in this study (173 cases, 1002 controls) were part of the community-based longitudinal comparative epidemiological study of African Americans in Indianapolis, and Yoruba Nigerians living in the city of Ibadan.
This GWAS data is also a part of the ADGC meta analysis to identify genetic loci associated with late-onset Alzheimer disease in African Americans (NG00039).
More information about the study can be found of the Indianapolis Ibadan Epidemiological Study of Dementia website.
The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is supported by a collaborative agreement from the National Institute on Aging, U24AG041689.
NG00047: The NIA supported this work through grants U01-AG032984, RC2-AG036528, U01-AG016976 (Dr Kukull); U24 AG026395, U24 AG026390, R01AG037212, R37 AG015473 (Dr Mayeux); K23AG034550 (Dr Reitz); U24-AG021886 (Dr Foroud); R01AG009956, RC2 AG036650 (Dr Hall); UO1 AG06781, UO1 HG004610 (Dr Larson); R01 AG009029 (Dr Farrer); 5R01AG20688 (Dr Fallin); P50 AG005133, AG030653 (Dr Kamboh); R01 AG019085 (Dr Haines); R01 AG1101, R01 AG030146, RC2 AG036650 (Dr Evans); P30AG10161, R01AG15819, R01AG30146, R01AG17917, R01AG15819 (Dr Bennett); R01AG028786 (Dr Manly); R01AG22018, P30AG10161 (Dr Barnes); P50AG16574 (Dr Ertekin-Taner, Dr Graff-Radford), R01 AG032990 (Dr Ertekin-Taner), KL2 RR024151 (Dr Ertekin-Taner); R01 AG027944, R01 AG028786 (Dr Pericak-Vance); P20 MD000546, R01 AG28786-01A1 (Dr Byrd); AG005138 (Dr Buxbaum); P50 AG05681, P01 AG03991, P01 AG026276 (Dr Goate); and P30AG019610, P30AG13846, U01-AG10483, R01CA129769, R01MH080295, R01AG017173, R01AG025259, R01AG33193, P50AG008702, P30AG028377, AG05128, AG025688, P30AG10133, P50AG005146, P50AG005134, P01AG002219, P30AG08051, MO1RR00096, UL1RR029893, P30AG013854, P30AG008017, R01AG026916, R01AG019085, P50AG016582, UL1RR02777, R01AG031581, P30AG010129, P50AG016573, P50AG016575, P50AG016576, P50AG016577, P50AG016570, P50AG005131, P50AG023501, P50AG019724, P30AG028383, P50AG008671, P30AG010124, P50AG005142, P30AG012300, AG010491, AG027944, AG021547, AG019757, P50AG005136 (Alzheimer Disease GeneticsConsortium [ADGC]). We thank Creighton Phelps, Stephen Synder, and Marilyn Miller from the NIA, who are ex-officio members of the ADGC. Support was also provided by the Alzheimer's Association (IIRG-08-89720 [Dr Farrer] and IIRG-05-14147 [Dr Pericak-Vance]), National Institute of Neurological Disorders and Stroke grant NS39764, National Institute of Mental Health grant MH60451, GlaxoSmithKline, and the Office of Research and Development, Biomedical Laboratory Research Program, US Department of Veterans Affairs Administration. For the ADGC, biological samples and associated phenotypic data used in primary data analyses were stored at principal investigators' institutions and at the National Cell Repository for Alzheimer's Disease (NCRAD) at Indiana University, funded by the NIA. Associated phenotypic data used in secondary data analyses were stored at the National Alzheimer's Coordinating Center and at the NIA Alzheimer's Disease Data Storage Site at the University of Pennsylvania, funded by the NIA. Contributors to the genetic analysis data included principal investigators on projects ndividually funded by the NIA, other NIH institutes, or private entities.