We’re moving! Datasets in the NIAGADS database are being transitioned to the DSS database, more info coming soon.
Data are from a Genome Wide Association Study (GWAS) reporting that genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer’s disease. Stage 1 GWAS data is provided here after undergoing quality control procedures described in Carrasquillo et al. (2009). Subjects in Stage 1 were diagnosed at 60-80 years of age and are from three series; two assembled from clinically diagnosed cases and controls and the third from subjects with an autopsy-confirmed diagnosis.
MAYO is a GWAS dataset used in the replication stage of the ADGC Naj et al. meta-analysis from 2011. It is one of the five cohorts assembled by ADGC to replicate genetic variant findings in LOAD.
The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is supported by a collaborative agreement from the National Institute on Aging, U24AG041689.
NG00043: Support for genotyping was provided entirely by the Robert and Clarice Smith and Abigail Van Buren Alzheimer’s Disease Research Program (Steven G. Younkin, R.C.P). Additional support for sample acquisition, sample management, data analysis, data sharing and manuscript preparation was provided by grants from the US National Institutes of Health, NIA R01 AG18023 (N.R.G.-R., Steven G. Younkin); Mayo Alzheimer's Disease Research Center, P50 AG16574 (R.C.P., D.W.D., N.R.G.-R., Steven G. Younkin); Mayo Alzheimer's Disease Patient Registry, U01 AG06576 (R.C.P.); and US National Institute on Aging, AG25711, AG17216, AG03949 (D.W.D.).