A multi-ethnic exome array study to identify low-frequency coding variants that affect susceptibility to Alzheimer's disease, frontotemporal dementia, and progressive supranuclear palsy. Also included are variant-level and gene-level association statistics. The p-value data is available to all users, while the access to the Exome Array data would be available soon.
NIAGADS staff is collecting Genomic Data Sharing (GDS) documentation for this dataset. Until we know how the study's cohort's Institutional Review Board wants the data to be shared, the data cannot be distributed. Information about GDS is available at https://osp.od.nih.gov/scientific-sharing/genomic-data-sharing/. If you have questions about GDS, you may contact Dr. Marilyn Miller, email@example.com. In the meantime, you may still submit a request for this dataset, but it will not be distributed until GDS documentation is complete.
The NIA Genetics of Alzheimer's Disease Data Storage Site (NIAGADS) is supported by a collaborative agreement from the National Institute on Aging, U24AG041689.
NG00040: This work was funded by grants from the National Institues of Health: F31 NS084556 (Mr Chen), P50 AG023501 (Dr Miller), RC1 AG035610 (Dr Coppola), R01 MH097268 (Dr Coppola), R01 AG26938 (Dr Geschwind), P01 AG019724 (Drs Levenson, B. L. Miller, and Geschwind), and R01 AG041762 (Dr Levenson); from the John Douglas French Alzheimer’s Foundation (Dr Coppola); the Tau Consortium (Drs Geschwind and Coppola); and the Jim Easton Consortium for Alzheimer’s Drug Discovery and Biomarker Development (Dr Ringman). We acknowledge the support of grant P30 NS062691 from the National Institute of Neurological Disorders and Stroke Informatics Center for Neurogenetics and Neurogenomics; grant P50
AG16570 from the University of California, Los Angeles, Alzheimer’s Disease Research Center; grant P50 AG016573 and POI AG000538 from the University of California, Irvine, Alzheimer’s Disease Research Center; grant P30 AG010129 from the University of California, Davis, Alzheimer’s Disease Center (Dr DeCarli); and grant P50 AG05142 from the University of Southern California Alzheimer’s Disease Research Center. Samples from the National Cell Repository for Alzheimer’s Disease, which receives government support under cooperative agreement grant U24 AG21886 from the National Institute on Aging, were used in this study. The National Alzheimer’s Coordinating Center database is funded by grant U01 AG016979 from the National Institute on Aging.