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Confirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder.

TitleConfirmation of association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene and bipolar I disorder.
Publication TypeJournal Article
Year of Publication2005
AuthorsLohoff, FW, Sander, T, Ferraro, TN, Dahl, JP, Gallinat, J, Berrettini, WH
JournalAm J Med Genet B Neuropsychiatr Genet
Volume139B
Issue1
Pagination51-3
Date Published2005 Nov 05
ISSN1552-4841
KeywordsAdult, Alleles, Amino Acid Substitution, Bipolar Disorder, Brain-Derived Neurotrophic Factor, European Continental Ancestry Group, Female, Gene Frequency, Genetic Predisposition to Disease, Genotype, Humans, Male, Methionine, Polymorphism, Genetic, Valine
Abstract

Recent studies have indicated that the brain-derived neurotrophic factor (BDNF) gene is involved in the etiology of bipolar disorder (BPD). Two family-based association studies showed that the Val allele of the functional polymorphism Val66Met in the BDNF gene is associated with BPD; however, others could not confirm the results. Here we performed a replication study in an independent sample and tested the hypothesis that the Val66 allele in the BDNF gene confers susceptibility to bipolar I disorder (BPI). Six hundred twenty-one patients with BPI and 998 control subjects were genotyped for the Val66Met polymorphism. All cases and controls were of European descent. All BPI patients had a positive family history of affective disorder. The frequency of the Val allele was significantly increased in BPI patient when compared to controls (chi2 = 4.8; df = 1; P = 0.028; two-sided; OR = 1.22; 95% CI: 1.02-1.47). Results confirm previous findings and suggest that the Val allele increases risk for BPI in patients of European descent. Further studies are necessary to elucidate the involvement of the BDNF gene in the pathophysiology of BPD.

DOI10.1002/ajmg.b.30215
Alternate JournalAm. J. Med. Genet. B Neuropsychiatr. Genet.
PubMed ID16152572