Middle Aged
W. K. Scott, Hauser, E. R., Schmechel, D. E., Welsh-Bohmer, K. A., Small, G. W., Roses, A. D., Saunders, A. M., Gilbert, J. R., Vance, J. M., Haines, J. L., and Pericak-Vance, M. A.,
“Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22.”,
Am J Hum Genet, vol. 73, no. 5, pp. 1041-51, 2003.
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.
Mitochondria
J. M. van der Walt, Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Small, G. W., Schmechel, D. E., P Doraiswamy, M., Gilbert, J. R., Haines, J. L., Vance, J. M., and Pericak-Vance, M. A.,
“Analysis of European mitochondrial haplogroups with Alzheimer disease risk.”,
Neurosci Lett, vol. 365, no. 1, pp. 28-32, 2004.
Multienzyme Complexes
A. C. Naj, Beecham, G. W., Martin, E. R., Gallins, P. J., Powell, E. H., Konidari, I., Whitehead, P. L., Cai, G., Haroutunian, V., Scott, W. K., Vance, J. M., Slifer, M. A., Gwirtsman, H. E., Gilbert, J. R., Haines, J. L., Buxbaum, J. D., and Pericak-Vance, M. A.,
“Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.”,
PLoS Genet, vol. 6, no. 9, p. e1001130, 2010.
Nuclear Family
A. L. Boyles, Scott, W. K., Martin, E. R., Schmidt, S., Li, Y. - J., Ashley-Koch, A., Bass, M. P., Schmidt, M., Pericak-Vance, M. A., Speer, M. C., and Hauser, E. R.,
“Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.”,
Hum Hered, vol. 59, no. 4, pp. 220-7, 2005.
Oligonucleotide Array Sequence Analysis
Y. - J. Li, Oliveira, S. A., Xu, P., Martin, E. R., Stenger, J. E., Scherzer, C. R., Hauser, M. A., Scott, W. K., Small, G. W., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., Stern, M. B., Hiner, B. C., Jankovic, J., Goetz, C. G., Mastaglia, F., Middleton, L. T., Roses, A. D., Saunders, A. M., Schmechel, D. E., Gullans, S. R., Haines, J. L., Gilbert, J. R., Vance, J. M., Pericak-Vance, M. A., Hulette, C., and Welsh-Bohmer, K. A.,
“Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.”,
Hum Mol Genet, vol. 12, no. 24, pp. 3259-67, 2003.
Parents
A. L. Boyles, Scott, W. K., Martin, E. R., Schmidt, S., Li, Y. - J., Ashley-Koch, A., Bass, M. P., Schmidt, M., Pericak-Vance, M. A., Speer, M. C., and Hauser, E. R.,
“Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.”,
Hum Hered, vol. 59, no. 4, pp. 220-7, 2005.
Parkinson Disease
Y. - J. Li, Oliveira, S. A., Xu, P., Martin, E. R., Stenger, J. E., Scherzer, C. R., Hauser, M. A., Scott, W. K., Small, G. W., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., Stern, M. B., Hiner, B. C., Jankovic, J., Goetz, C. G., Mastaglia, F., Middleton, L. T., Roses, A. D., Saunders, A. M., Schmechel, D. E., Gullans, S. R., Haines, J. L., Gilbert, J. R., Vance, J. M., Pericak-Vance, M. A., Hulette, C., and Welsh-Bohmer, K. A.,
“Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.”,
Hum Mol Genet, vol. 12, no. 24, pp. 3259-67, 2003.
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.
Polymerase Chain Reaction
J. M. van der Walt, Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Small, G. W., Schmechel, D. E., P Doraiswamy, M., Gilbert, J. R., Haines, J. L., Vance, J. M., and Pericak-Vance, M. A.,
“Analysis of European mitochondrial haplogroups with Alzheimer disease risk.”,
Neurosci Lett, vol. 365, no. 1, pp. 28-32, 2004.
Polymorphism, Single Nucleotide
A. C. Naj, Beecham, G. W., Martin, E. R., Gallins, P. J., Powell, E. H., Konidari, I., Whitehead, P. L., Cai, G., Haroutunian, V., Scott, W. K., Vance, J. M., Slifer, M. A., Gwirtsman, H. E., Gilbert, J. R., Haines, J. L., Buxbaum, J. D., and Pericak-Vance, M. A.,
“Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.”,
PLoS Genet, vol. 6, no. 9, p. e1001130, 2010.
Y. - J. Li, Oliveira, S. A., Xu, P., Martin, E. R., Stenger, J. E., Scherzer, C. R., Hauser, M. A., Scott, W. K., Small, G. W., Nance, M. A., Watts, R. L., Hubble, J. P., Koller, W. C., Pahwa, R., Stern, M. B., Hiner, B. C., Jankovic, J., Goetz, C. G., Mastaglia, F., Middleton, L. T., Roses, A. D., Saunders, A. M., Schmechel, D. E., Gullans, S. R., Haines, J. L., Gilbert, J. R., Vance, J. M., Pericak-Vance, M. A., Hulette, C., and Welsh-Bohmer, K. A.,
“Glutathione S-transferase omega-1 modifies age-at-onset of Alzheimer disease and Parkinson disease.”,
Hum Mol Genet, vol. 12, no. 24, pp. 3259-67, 2003.
J. M. van der Walt, Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Small, G. W., Schmechel, D. E., P Doraiswamy, M., Gilbert, J. R., Haines, J. L., Vance, J. M., and Pericak-Vance, M. A.,
“Analysis of European mitochondrial haplogroups with Alzheimer disease risk.”,
Neurosci Lett, vol. 365, no. 1, pp. 28-32, 2004.
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.
Reproducibility of Results
A. C. Naj, Beecham, G. W., Martin, E. R., Gallins, P. J., Powell, E. H., Konidari, I., Whitehead, P. L., Cai, G., Haroutunian, V., Scott, W. K., Vance, J. M., Slifer, M. A., Gwirtsman, H. E., Gilbert, J. R., Haines, J. L., Buxbaum, J. D., and Pericak-Vance, M. A.,
“Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.”,
PLoS Genet, vol. 6, no. 9, p. e1001130, 2010.
Risk Assessment
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.
Risk Factors
J. M. van der Walt, Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Small, G. W., Schmechel, D. E., P Doraiswamy, M., Gilbert, J. R., Haines, J. L., Vance, J. M., and Pericak-Vance, M. A.,
“Analysis of European mitochondrial haplogroups with Alzheimer disease risk.”,
Neurosci Lett, vol. 365, no. 1, pp. 28-32, 2004.
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.
Sex Factors
J. M. van der Walt, Dementieva, Y. A., Martin, E. R., Scott, W. K., Nicodemus, K. K., Kroner, C. C., Welsh-Bohmer, K. A., Saunders, A. M., Roses, A. D., Small, G. W., Schmechel, D. E., P Doraiswamy, M., Gilbert, J. R., Haines, J. L., Vance, J. M., and Pericak-Vance, M. A.,
“Analysis of European mitochondrial haplogroups with Alzheimer disease risk.”,
Neurosci Lett, vol. 365, no. 1, pp. 28-32, 2004.
Software
W. K. Scott, Hauser, E. R., Schmechel, D. E., Welsh-Bohmer, K. A., Small, G. W., Roses, A. D., Saunders, A. M., Gilbert, J. R., Vance, J. M., Haines, J. L., and Pericak-Vance, M. A.,
“Ordered-subsets linkage analysis detects novel Alzheimer disease loci on chromosomes 2q34 and 15q22.”,
Am J Hum Genet, vol. 73, no. 5, pp. 1041-51, 2003.
Statistics, Nonparametric
A. L. Boyles, Scott, W. K., Martin, E. R., Schmidt, S., Li, Y. - J., Ashley-Koch, A., Bass, M. P., Schmidt, M., Pericak-Vance, M. A., Speer, M. C., and Hauser, E. R.,
“Linkage disequilibrium inflates type I error rates in multipoint linkage analysis when parental genotypes are missing.”,
Hum Hered, vol. 59, no. 4, pp. 220-7, 2005.
United States
Y. - J. Li, Scott, W. K., Zhang, L., Lin, P. - I., Oliveira, S. A., Skelly, T., Doraiswamy, M. P., Welsh-Bohmer, K. A., Martin, E. R., Haines, J. L., Pericak-Vance, M. A., and Vance, J. M.,
“Revealing the role of glutathione S-transferase omega in age-at-onset of Alzheimer and Parkinson diseases.”,
Neurobiol Aging, vol. 27, no. 8, pp. 1087-93, 2006.