Alzheimer's disease genetics: from the bench to the clinic.

TitleAlzheimer's disease genetics: from the bench to the clinic.
Publication TypeJournal Article
Year of Publication2014
AuthorsKarch CM, Cruchaga C, Goate AM
JournalNeuron
Volume83
Issue1
Pagination11-26
Date Published2014 Jul 02
ISSN1097-4199
KeywordsAlzheimer Disease, Animals, Case-Control Studies, Genetic Predisposition to Disease, Genetic Variation, Humans, Pharmacogenetics
Abstract

Alzheimer's disease (AD) is a clinically heterogeneous neurodegenerative disease with a strong genetic component. Several genes have been associated with AD risk for nearly 20 years. However, it was not until the recent technological advances that allow for the analysis of millions of polymorphisms in thousands of subjects that we have been able to advance our understanding of the genetic complexity of AD susceptibility. Genome-wide association studies and whole-exome and whole-genome sequencing have revealed more than 20 loci associated with AD risk. These studies have provided insights into the molecular pathways that are altered in AD pathogenesis, which have, in turn, provided insight into novel therapeutic targets.

DOI10.1016/j.neuron.2014.05.041
Alternate JournalNeuron
PubMed ID24991952
PubMed Central IDPMC4120741
Grant ListR01 AG044546 / AG / NIA NIH HHS / United States
K01 AG046374 / AG / NIA NIH HHS / United States
AG035083 / AG / NIA NIH HHS / United States
AG044546 / AG / NIA NIH HHS / United States
R01 AG035083 / AG / NIA NIH HHS / United States