The National Institute on Aging Genetics of Alzheimer's Disease Data Storage Site
Publications
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2024
2024,
NIAGADS: A Comprehensive National Data Repository for Alzheimer's Disease and Related Dementia Genetics and Genomics Research
Kuzma, A., et al.
2024,
Translational Psychiatry
Causal relationships between dyslexia and the risk of eight dementias
Zhu, P., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Cognitive resilience to Alzheimer's disease characterized by cell-type abundance
O'Neill, N., et al.
2024,
Nature Communications
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes
Farrell, K., et al.
2024,
Molecular Neurodegeneration
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Wang, H., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry
Ray, NR., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD)
Cheng, P., et al.
2024,
Journal of Medical Imaging (Bellingham, Wash.)
Field-of-view extension for brain diffusion MRI via deep generative models
Gao, C., et al.
2024,
bioRxiv: The Preprint Server for Biology
Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease
Peterson, A., et al.
2024,
Research Square
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways
Cruchaga, C., et al.
2024,
eLife
Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes
Yan, D., et al.
2024,
Life Science Alliance
A comparative study of structural variant calling in WGS from Alzheimer's disease families
Malamon, JS., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data
Wang, Y., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes
Andrews, SJ., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
The Role of X Chromosome in Alzheimer's Disease Genetics
Belloy, ME., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
Comparative gene regulatory networks modulating APOE expression in microglia and astrocytes
Brase, L., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease
Xicota, L., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genetic associations with dementia-related proteinopathy: Application of item response theory
Katsumata, Y., et al.
2024,
iScience
AI-enabled evaluation of genome-wide association relevance and polygenic risk score prediction in Alzheimer's disease
Platt, DE., et al.
2024,
American Journal of Human Genetics
The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function
Zhang, J., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
Wang, P., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and MAPT Sub-haplotypes
Wang, H., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Sex-specific genetic architecture of late-life memory performance
Eissman, JM., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge
Greenfest-Allen, E., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease
Archer, DB., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy
Wang, H., et al.
2024,
Nature Communications
Human whole-exome genotype data for Alzheimer's disease
Leung, YY., et al.
2024,
Journal of Alzheimer's disease: JAD
Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores
Hermes, S., et al.
2024,
Alzheimer's & Dementia (New York, N. Y.)
Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains
Cary, GA., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
DNA from multiple viral species is associated with Alzheimer's disease risk
Tejeda, M., et al.
2023
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews
Li, D., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease
Guo, MH., et al.
2023,
PLoS genetics
Transfer learning with false negative control improves polygenic risk prediction
Jeng, XJ., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease
Bai, H., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles
Chung, J., et al.
2023,
Bioinformatics (Oxford, England)
hipFG: high-throughput harmonization and integration pipeline for functional genomics data
Cifello, J., et al.
2023,
Aging Cell
Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci
Dato, S., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains
Novotny, BC., et al.
2023,
Journal of Alzheimer's disease: JAD
Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes
Sible, IJ., et al.
2022
2022,
Nature Communications
The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization
Korologou-Linden, R., et al.
2022,
Frontiers in Aging Neuroscience
The role of structural variations in Alzheimer's disease and other neurodegenerative diseases
Wang, H., et al.
2022,
Journal of Alzheimer's disease: JAD
The Advisory Group on Risk Evidence Education for Dementia: Multidisciplinary and Open to All
Rosen, AC., et al.
2021
2021,
Biomedicines
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases
Lam, S., et al.
2021,
Neurobiology of Aging
Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease
Lawingco, T., et al.
2021,
Scientific Reports
Reconcile the debate over protective effects of BCG vaccine against COVID-19
Fu, W., et al.
2021,
Acta Neuropathologica
Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population
Kirola, L., et al.
2021,
Cytometry. Part A: The Journal of the International Society for Analytical Cytology
Tailor: Targeting heavy tails in flow cytometry data with fast, interpretable mixture modeling
Ionita, M., et al.
2021,
Genetic Epidemiology
Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics
Li, C., et al.
2021,
Methods in Molecular Biology (Clifton, N.J.)
Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations
Amlie-Wolf, A., et al.
2021,
Heart & Lung: The Journal of Critical Care
Testing influences of APOE and BDNF genes and heart failure on cognitive function
Jung, M., et al.
2021,
Journal of Neurogenetics
Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles
Curtis, D.
2020
2020,
Neuromolecular Medicine
Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk
Miao, X., et al.
2020,
Aging Cell
Underlying features of epigenetic aging clocks in vivo and in vitro
Liu, Z., et al.
2020,
Molecular Psychiatry
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Bis, JC., et al.
2020,
Bioinformatics (Oxford, England)
SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants
Kuksa, PP., et al.
2020,
Nature Communications
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Reiman, EM., et al.
2020,
Acta Neuropathologica
Overlapping genetic architecture between Parkinson disease and melanoma
Dube, U., et al.
2020,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer
Pathak, GA., et al.
2020,
Journal of Alzheimer's disease: JAD
Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers
Fan, K., et al.
2019
2019,
Brain: A Journal of Neurology
Sex differences in the genetic predictors of Alzheimer's pathology
Dumitrescu, L., et al.
2019,
Genome Biology
Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight
Ebbert, MTW., et al.
2019,
Bioinformatics (Oxford, England)
VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project
Leung, YY., et al.
2019,
Neurobiology of Aging
Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs
Katsumata, Y., et al.
2019,
The American Journal of Clinical Nutrition
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study
Williams, DM., et al.
2018
2018,
Acta Neuropathologica
Sex-specific genetic predictors of Alzheimer's disease biomarkers
Deming, Y., et al.
2018,
JAMA neurology
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau
Hohman, TJ., et al.
2018,
Nucleic Acids Research
SPAR: small RNA-seq portal for analysis of sequencing experiments
Kuksa, PP., et al.
2018,
Annals of Clinical and Translational Neurology
Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease
Raghavan, NS., et al.
2018,
Genes, Brain, and Behavior
Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease
Blue, EE., et al.
2018,
Annals of Clinical and Translational Neurology
Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease
Vardarajan, BN., et al.
2018,
Proceedings of the National Academy of Sciences of the United States of America
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis
Zhou, X., et al.
2018,
Alzheimer's Research & Therapy
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease
Chung, J., et al.
2018,
American Journal of Alzheimer's Disease and Other Dementias
Val66Met Polymorphism in BDNF Has No Sexual and APOE ε4 Status-Based Dimorphic Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts
Zhao, Q., et al.
2017
2017,
Neurology. Genetics
The Alzheimer's Disease Sequencing Project: Study design and sample selection
Beecham, GW., et al.
2017,
PLoS medicine
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study
Steele, NZR., et al.
2017,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
Mez, J., et al.
2016
2016,
Neurology. Genetics
SORL1 mutations in early- and late-onset Alzheimer disease
Cuccaro, ML., et al.
2016,
Biological Psychiatry
Genetic Markers of Human Evolution Are Enriched in Schizophrenia
Srinivasan, S., et al.
2016,
Neurobiology of Aging
The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable
Mez, J., et al.
2016,
Neurobiology of Aging
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium
Hohman, TJ., et al.
2015
2015,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease
Barral, S., et al.
2015,
PloS One
Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
Amlie-Wolf, A., et al.
2014
2014,
Methods (San Diego, Calif.)
Using machine learning and high-throughput RNA sequencing to classify the precursors of small non-coding RNAs
Ryvkin, P., et al.
2014,
PloS One
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Escott-Price, V., et al.
2013
2013,
Nature Genetics
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Lambert, JC., et al.
2011
2011,
Nature Genetics
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease