LD-informed deep learning for Alzheimer's gene loci detection using WGS data
Jo, T., et al.
2025,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease
Peterson, A., et al.
2024
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Association of common and rare variants with Alzheimer's disease in more than 13,000 diverse individuals with whole-genome sequencing from the Alzheimer's Disease Sequencing Project
Lee, W., et al.
2024,
bioRxiv: The Preprint Server for Biology
CHARMER: detecting and harmonizing high-confidence chromatin interactions across tissues and Hi-C protocols
Cole, S., et al.
2024,
Nature Genetics
GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia
Shade, LMP., et al.
2024,
Alzheimer's Research & Therapy
Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites
Tong, T., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Whole-genome sequencing study in Koreans identifies novel loci for Alzheimer's disease
Kang, M., et al.
2024,
Translational Psychiatry
Causal relationships between dyslexia and the risk of eight dementias
Zhu, P., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Cognitive resilience to Alzheimer's disease characterized by cell-type abundance
O'Neill, N., et al.
2024,
Nature Communications
Genetic, transcriptomic, histological, and biochemical analysis of progressive supranuclear palsy implicates glial activation and novel risk genes
Farrell, K., et al.
2024,
Molecular Neurodegeneration
Whole-genome sequencing analysis reveals new susceptibility loci and structural variants associated with progressive supranuclear palsy
Wang, H., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Extended genome-wide association study employing the African genome resources panel identifies novel susceptibility loci for Alzheimer's disease in individuals of African ancestry
Ray, NR., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
A Specialized Reference Panel with Structural Variants Integration for Improving Genotype Imputation in Alzheimer's Disease and Related Dementias (ADRD)
Cheng, P., et al.
2024,
Journal of Medical Imaging (Bellingham, Wash.)
Field-of-view extension for brain diffusion MRI via deep generative models
Gao, C., et al.
2024,
bioRxiv: The Preprint Server for Biology
Sex, racial, and APOE-ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease
Peterson, A., et al.
2024,
Research Square
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways
Cruchaga, C., et al.
2024,
eLife
Biobank-wide association scan identifies risk factors for late-onset Alzheimer's disease and endophenotypes
Yan, D., et al.
2024,
Life Science Alliance
A comparative study of structural variant calling in WGS from Alzheimer's disease families
Malamon, JS., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Key variants via the Alzheimer's Disease Sequencing Project whole genome sequence data
Wang, Y., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
The Role of Genomic-Informed Risk Assessments in Predicting Dementia Outcomes
Andrews, SJ., et al.
2024,
Journal of Neurology, Neurosurgery, and Psychiatry
Genetics impact risk of Alzheimer's disease through mechanisms modulating structural brain morphology in late life
Korologou-Linden, R., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
The Role of X Chromosome in Alzheimer's Disease Genetics
Belloy, ME., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
Comparative gene regulatory networks modulating APOE expression in microglia and astrocytes
Brase, L., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Whole genome-wide sequence analysis of long-lived families (Long-Life Family Study) identifies MTUS2 gene associated with late-onset Alzheimer's disease
Xicota, L., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genetic associations with dementia-related proteinopathy: Application of item response theory
Katsumata, Y., et al.
2024,
iScience
AI-enabled evaluation of genome-wide association relevance and polygenic risk score prediction in Alzheimer's disease
Platt, DE., et al.
2024,
American Journal of Human Genetics
The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function
Zhang, J., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association studies identify novel loci in rapidly progressive Alzheimer's disease
Wang, P., et al.
2024,
medRxiv: The Preprint Server for Health Sciences
Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and MAPT Sub-haplotypes
Wang, H., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Sex-specific genetic architecture of late-life memory performance
Eissman, JM., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
NIAGADS Alzheimer's GenomicsDB: A resource for exploring Alzheimer's disease genetic and genomic knowledge
Greenfest-Allen, E., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease
Archer, DB., et al.
2024,
Nature Communications
Human whole-exome genotype data for Alzheimer's disease
Leung, YY., et al.
2024,
Journal of Alzheimer's disease: JAD
African Ancestry Individuals with Higher Educational Attainment Are Resilient to Alzheimer's Disease Measured by pTau181
Rajabli, F., et al.
2024,
Journal of Alzheimer's disease: JAD
Epistatic Features and Machine Learning Improve Alzheimer's Disease Risk Prediction Over Polygenic Risk Scores
Hermes, S., et al.
2024,
Alzheimer's & Dementia (New York, N. Y.)
Genetic and multi-omic risk assessment of Alzheimer's disease implicates core associated biological domains
Cary, GA., et al.
2024,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
DNA from multiple viral species is associated with Alzheimer's disease risk
Tejeda, M., et al.
2023
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Novel loci for Alzheimer's disease identified by a genome-wide association study in Ashkenazi Jews
Li, D., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
Polygenic burden of short tandem repeat expansions promote risk for Alzheimer's disease
Guo, MH., et al.
2023,
Bioinformatics (Oxford, England)
hipFG: high-throughput harmonization and integration pipeline for functional genomics data
Cifello, J., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Alzheimer's disease heterogeneity explained by polygenic risk scores derived from brain transcriptomic profiles
Chung, J., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
A haptoglobin (HP) structural variant alters the effect of APOE alleles on Alzheimer's disease
Bai, H., et al.
2023,
PLoS genetics
Transfer learning with false negative control improves polygenic risk prediction
Jeng, XJ., et al.
2023,
Research Square
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects
Lee, W., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
Structural Variation Detection and Association Analysis of Whole-Genome-Sequence Data from 16,905 Alzheimer's Diseases Sequencing Project Subjects
Wang, H., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
Association of Common and Rare Variants with Alzheimer's Disease in over 13,000 Diverse Individuals with Whole-Genome Sequencing from the Alzheimer's Disease Sequencing Project
Lee, W., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
The Early-Onset Alzheimer's Disease Whole-Genome Sequencing Project: Study design and methodology
Ray, NR., et al.
2023,
Aging Cell
Sex- and APOE-specific genetic risk factors for late-onset Alzheimer's disease: Evidence from gene-gene interaction of longevity-related loci
Dato, S., et al.
2023,
Journal of Neuropathology and Experimental Neurology
LATE-NC risk alleles (in TMEM106B, GRN, and ABCC9 genes) among persons with African ancestry
Katsumata, Y., et al.
2023,
International Journal of Stroke: Official Journal of the International Stroke Society
Pleiotropy analysis between lobar intracerebral hemorrhage and CSF β-amyloid highlights new and established associations
Marini, S., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
APOE loss-of-function variants: Compatible with longevity and associated with resistance to Alzheimer's Disease pathology
Chemparathy, A., et al.
2023,
HGG advances
Admixture mapping implicates 13q33.3 as ancestry-of-origin locus for Alzheimer disease in Hispanic and Latino populations
Horimoto, ARVR., et al.
2023,
medRxiv: The Preprint Server for Health Sciences
Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies LRRC4C, LHX5-AS1 and nominates ancestry-specific loci PTPRK , GRB14 , and KIAA0825 as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium
Rajabli, F., et al.
2023,
Nature Medicine
Clonal hematopoiesis is associated with protection from Alzheimer's disease
Bouzid, H., et al.
2023,
Molecular Neurodegeneration
A genome-wide search for pleiotropy in more than 100,000 harmonized longitudinal cognitive domain scores
Kang, M., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Admixture mapping identifies novel Alzheimer's disease risk regions in African Americans
Rajabli, F., et al.
2023,
Translational Psychiatry
Circulating S100B levels at birth and risk of six major neuropsychiatric or neurological disorders: a two-sample Mendelian Randomization Study
Pan, M., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains
Novotny, BC., et al.
2023,
Genes
Interaction between KLOTHO-VS Heterozygosity and APOE ε4 Allele Predicts Rate of Cognitive Decline in Late-Onset Alzheimer's Disease
Chen, XR., et al.
2023,
Communications Medicine
Deep learning-based polygenic risk analysis for Alzheimer's disease prediction
Zhou, X., et al.
2023,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association and multi-omics studies identify MGMT as a novel risk gene for Alzheimer's disease among women
Chung, J., et al.
2023,
Molecular Psychiatry
Neuroimmune transcriptome changes in patient brains of psychiatric and neurological disorders
Chen, Y., et al.
2023,
Neurobiology of Aging
Investigation of the independent role of a rare APOE variant (L28P; APOE*4Pittsburgh) in late-onset Alzheimer disease
Fan, K., et al.
2023,
Neuron
TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4
Gratuze, M., et al.
2023,
Scientific Reports
Explainable machine learning aggregates polygenic risk scores and electronic health records for Alzheimer's disease prediction
Gao, XR., et al.
2023,
Molecular Neurodegeneration
Genome-wide association study of brain biochemical phenotypes reveals distinct genetic architecture of Alzheimer's disease related proteins
Oatman, SR., et al.
2023,
Journal of Alzheimer's disease: JAD
Polygenic Liability to Alzheimer's Disease Is Associated with a Wide Range of Chronic Diseases: A Cohort Study of 312,305 Participants
Wu, B., et al.
2023,
Journal of Alzheimer's disease: JAD
Visit-to-Visit Blood Pressure Variability and Cognitive Decline in Apolipoprotein ɛ4 Carriers versus Apolipoprotein ɛ3 Homozygotes
Sible, IJ., et al.
2023,
Alzheimer's & Dementia (Amsterdam, Netherlands)
Early-onset Alzheimer's disease explained by polygenic risk of late-onset disease?
Mantyh, WG., et al.
2022
2022,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Progranulin mutations in clinical and neuropathological Alzheimer's disease
Vardarajan, BN., et al.
2022,
Neurobiology of Disease
Multiple gene variants linked to Alzheimer's-type clinical dementia via GWAS are also associated with non-Alzheimer's neuropathologic entities
Katsumata, Y., et al.
2022,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Protein phosphatase 2A and complement component 4 are linked to the protective effect of APOE ɛ2 for Alzheimer's disease
Jun, GR., et al.
2022,
Journal of Psychiatric Research
Association of autoimmune diseases with Alzheimer's disease: A mendelian randomization study
Yeung, CHC., et al.
2022,
Human Molecular Genetics
Scalable approaches for functional analyses of whole-genome sequencing non-coding variants
Kuksa, PP., et al.
2022,
HGG advances
A scalable Bayesian functional GWAS method accounting for multivariate quantitative functional annotations with applications for studying Alzheimer disease
Chen, J., et al.
2022,
Molecular Psychiatry
Cognitive performance protects against Alzheimer's disease independently of educational attainment and intelligence
Hu, Y., et al.
2022,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Mendelian randomization highlights causal association between genetically increased C-reactive protein levels and reduced Alzheimer's disease risk
Hu, Y., et al.
2022,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Integration of GWAS and brain transcriptomic analyses in a multiethnic sample of 35,245 older adults identifies DCDC2 gene as predictor of episodic memory maintenance
Gao, Y., et al.
2022,
Movement Disorders: Official Journal of the Movement Disorder Society
Common Variants Near ZIC1 and ZIC4 in Autopsy-Confirmed Multiple System Atrophy
Hopfner, F., et al.
2022,
Bioinformatics (Oxford, England)
Omnibus and robust deconvolution scheme for bulk RNA sequencing data integrating multiple single-cell reference sets and prior biological knowledge
Chen, C., et al.
2022,
Nature Communications
The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization
Korologou-Linden, R., et al.
2022,
Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Genome-wide association study of brain arteriolosclerosis
Shade, LM., et al.
2022,
Brain: A Journal of Neurology
Sex differences in the genetic architecture of cognitive resilience to Alzheimer's disease
Eissman, JM., et al.
2022,
Scientific Reports
Using a two-sample mendelian randomization analysis to explore the relationship between physical activity and Alzheimer's disease
Zhang, B., et al.
2022,
PLoS genetics
A locus at 19q13.31 significantly reduces the ApoE ε4 risk for Alzheimer's Disease in African Ancestry
Rajabli, F., et al.
2022,
PLoS genetics
Integrated analysis of direct and proxy genome wide association studies highlights polygenicity of Alzheimer's disease outside of the APOE region
de la Fuente, J., et al.
2022,
BMC medical genomics
Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains
Varathan, P., et al.
2022,
Scientific Reports
ODACH: a one-shot distributed algorithm for Cox model with heterogeneous multi-center data
Luo, C., et al.
2022,
Scientific Reports
Manifestations of Alzheimer's disease genetic risk in the blood are evident in a multiomic analysis in healthy adults aged 18 to 90
Heath, L., et al.
2022,
Nature Neuroscience
Integrating whole-genome sequencing with multi-omic data reveals the impact of structural variants on gene regulation in the human brain
Vialle, RA., et al.
2022,
Nature Genetics
New insights into the genetic etiology of Alzheimer's disease and related dementias
Bellenguez, C., et al.
2022,
Genome Research
An association test of the spatial distribution of rare missense variants within protein structures identifies Alzheimer's disease-related patterns
Jin, B., et al.
2022,
Neurobiology of Aging
Association between WWOX/MAF variants and dementia-related neuropathologic endophenotypes
Dugan, AJ., et al.
2022,
Epilepsia
Association of ultra-rare coding variants with genetic generalized epilepsy: A case-control whole exome sequencing study
Koko, M., et al.
2022,
NAR genomics and bioinformatics
FILER: a framework for harmonizing and querying large-scale functional genomics knowledge
Kuksa, PP., et al.
2022,
BMJ open
Association of social isolation, loneliness and genetic risk with incidence of dementia: UK Biobank Cohort Study
Elovainio, M., et al.
2022,
Alzheimer's Research & Therapy
Challenges at the APOE locus: a robust quality control approach for accurate APOE genotyping
Belloy, ME., et al.
2022,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Association of mitochondrial variants and haplogroups identified by whole exome sequencing with Alzheimer's disease
Zhang, X., et al.
2022,
Alzheimer's Research & Therapy
Mendelian randomization highlights significant difference and genetic heterogeneity in clinically diagnosed Alzheimer's disease GWAS and self-report proxy phenotype GWAX
Liu, H., et al.
2022,
Nature Communications
Transcriptional programs regulating neuronal differentiation are disrupted in DLG2 knockout human embryonic stem cells and enriched for schizophrenia and related disorders risk variants
Sanders, B., et al.
2022,
Journal of Alzheimer's disease: JAD
Alzheimer's Disease Variant Portal: A Catalog of Genetic Findings for Alzheimer's Disease
Kuksa, PP., et al.
2022,
Journal of Alzheimer's disease: JAD
Polygenic Risk Scores in Alzheimer's Disease Genetics: Methodology, Applications, Inclusion, and Diversity
Clark, K., et al.
2022,
Journal of Alzheimer's disease: JAD
Parkinson's Disease rs117896735 Variant Regulates INPP5F Expression in Brain Tissues and Increases Risk of Alzheimer's Disease
Xue, F., et al.
2022,
Dementia and Geriatric Cognitive Disorders Extra
Early-Stage MRI Volumetric Differences in White Matter Hyperintensity and Temporal Lobe Volumes between Autopsy-Confirmed Alzheimer's Disease, Cerebral Small Vessel Disease, and Mixed Pathologies
Yang, D.
2022,
Journal of Alzheimer's disease: JAD
Investigating Causal Relations Between Circulating Metabolites and Alzheimer's Disease: A Mendelian Randomization Study
Huang, S., et al.
2022,
Journal of Alzheimer's disease: JAD
The Advisory Group on Risk Evidence Education for Dementia: Multidisciplinary and Open to All
Rosen, AC., et al.
2022,
Frontiers in Aging Neuroscience
The role of structural variations in Alzheimer's disease and other neurodegenerative diseases
Wang, H., et al.
2021
2021,
Translational Psychiatry
Genetically regulated expression in late-onset Alzheimer's disease implicates risk genes within known and novel loci
Chen, H., et al.
2021,
American Journal of Human Genetics
Genome-wide analysis of common and rare variants via multiple knockoffs at biobank scale, with an application to Alzheimer disease genetics
He, Z., et al.
2021,
Genes & Nutrition
Mendelian randomization to evaluate the effect of plasma vitamin C levels on the risk of Alzheimer's disease
Liu, H., et al.
2021,
Biomedicines
Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases
Lam, S., et al.
2021,
Alzheimer's Research & Therapy
Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study
Huang, S., et al.
2021,
Science Translational Medicine
In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline
Jacobs, HIL., et al.
2021,
Cell Systems
Dysregulation of the secretory pathway connects Alzheimer's disease genetics to aggregate formation
Kuo, C., et al.
2021,
Translational Psychiatry
Cortical structure and the risk for Alzheimer's disease: a bidirectional Mendelian randomization study
Wu, B., et al.
2021,
Acta Neuropathologica Communications
Analysis of genes (TMEM106B, GRN, ABCC9, KCNMB2, and APOE) implicated in risk for LATE-NC and hippocampal sclerosis provides pathogenetic insights: a retrospective genetic association study
Dugan, AJ., et al.
2021,
American Journal of Epidemiology
A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator
Sanyal, N., et al.
2021,
Annals of Neurology
Polygenic Risk Score for Alzheimer's Disease in Caribbean Hispanics
Sariya, S., et al.
2021,
PLoS genetics
Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences
Zhan, L., et al.
2021,
Nature Communications
Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores
Leonenko, G., et al.
2021,
BMC medicine
Investigating causal relationships between exposome and human longevity: a Mendelian randomization analysis
Huang, S., et al.
2021,
Nature Communications
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
de Rojas, I., et al.
2021,
Genes
A Genetic Study of Cerebral Atherosclerosis Reveals Novel Associations with NTNG1 and CNOT3
Vattathil, SM., et al.
2021,
Nature Communications
Identification of putative causal loci in whole-genome sequencing data via knockoff statistics
He, Z., et al.
2021,
The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
A Non-APOE Polygenic Risk Score for Alzheimer's Disease Is Associated With Cerebrospinal Fluid Neurofilament Light in a Representative Sample of Cognitively Unimpaired 70-Year Olds
Skoog, I., et al.
2021,
Neurobiology of Aging
Genetic variants in glutamate-, Aβ-, and tau-related pathways determine polygenic risk for Alzheimer's disease
Lawingco, T., et al.
2021,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Harnessing the paradoxical phenotypes of APOE ɛ2 and APOE ɛ4 to identify genetic modifiers in Alzheimer's disease
Kim, YW., et al.
2021,
Journal of Psychiatric Research
Evaluation relationships between subjective wellbeing, personality traits, and Alzheimer's disease: A two-sample Mendelian randomization study
Ma, Y., et al.
2021,
Proceedings of the National Academy of Sciences of the United States of America
Mendelian randomization identifies blood metabolites previously linked to midlife cognition as causal candidates in Alzheimer's disease
Lord, J., et al.
2021,
Scientific Reports
Reconcile the debate over protective effects of BCG vaccine against COVID-19
Lack of evidence supporting a role for DPP6 sequence variants in Alzheimer's disease in the European American population
Kirola, L., et al.
2021,
PLoS genetics
Novel Variance-Component TWAS method for studying complex human diseases with applications to Alzheimer's dementia
Tang, S., et al.
2021,
Genome Biology
Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders
Nabais, MF., et al.
2021,
Genes
The Impact of Complement Genes on the Risk of Late-Onset Alzheimer's Disease
Carpanini, SM., et al.
2021,
Alzheimer Disease and Associated Disorders
Clinical Profiles of Arteriolosclerosis and Alzheimer Disease at Mild Cognitive Impairment and Mild Dementia in a National Neuropathology Cohort
Yang, D.
2021,
Neurobiology of Aging
Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers
Fulton-Howard, B., et al.
2021,
Translational Psychiatry
Exome-wide age-of-onset analysis reveals exonic variants in ERN1 and SPPL2C associated with Alzheimer's disease
He, L., et al.
2021,
Translational Psychiatry
Long runs of homozygosity are associated with Alzheimer's disease
Moreno-Grau, S., et al.
2021,
Alzheimer's Research & Therapy
Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer's disease: a Mendelian randomization study
Ou, Y., et al.
2021,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Non-coding variants in MYH11, FZD3, and SORCS3 are associated with dementia in women
Blue, EE., et al.
2021,
Genetic Epidemiology
Set-based genetic association and interaction tests for survival outcomes based on weighted V statistics
Li, C., et al.
2021,
Cytometry. Part A: The Journal of the International Society for Analytical Cytology
Tailor: Targeting heavy tails in flow cytometry data with fast, interpretable mixture modeling
Ionita, M., et al.
2021,
Human Genomics
Convergent lines of evidence support BIN1 as a risk gene of Alzheimer's disease
Zhu, J., et al.
2021,
BMC medicine
rs1990622 variant associates with Alzheimer's disease and regulates TMEM106B expression in human brain tissues
Hu, Y., et al.
2021,
Alzheimer's Research & Therapy
Association between polygenic risk score of Alzheimer's disease and plasma phosphorylated tau in individuals from the Alzheimer's Disease Neuroimaging Initiative
Zettergren, A., et al.
2021,
American Journal of Epidemiology
A Likelihood Ratio Test for Gene-Environment Interaction Based on the Trend Effect of Genotype Under an Additive Risk Model Using the Gene-Environment Independence Assumption
de Rochemonteix, M., et al.
2021,
Frontiers in Aging Neuroscience
Similar Genetic Architecture of Alzheimer's Disease and Differential APOE Effect Between Sexes
Wang, H., et al.
2021,
Journal of Neurogenetics
Analysis of whole genome sequenced cases and controls shows that the association of variants in TOMM40, BCAM, NECTIN2 and APOC1 with late onset Alzheimer's disease is driven by linkage disequilibrium with APOE ε2/ε3/ε4 alleles
Curtis, D.
2021,
Alzheimer's & Dementia (Amsterdam, Netherlands)
Causal association of cognitive reserve on Alzheimer's disease with putative sex difference
Wang, H., et al.
2021,
Alzheimer's & Dementia (Amsterdam, Netherlands)
Polygenic risk scores for Alzheimer's disease are related to dementia risk in APOE ɛ4 negatives
Najar, J., et al.
2021,
Brain Communications
Defining functional variants associated with Alzheimer's disease in the induced immune response
Harwood, JC., et al.
2021,
JAMA neurology
Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis
Kunkle, BW., et al.
2021,
Science Advances
Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets
Neff, RA., et al.
2021,
Alzheimer's & Dementia (Amsterdam, Netherlands)
Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
Huq, AJ., et al.
2021,
Journal of Alzheimer's disease: JAD
Five-Year Change in Body Mass Index Predicts Conversion to Mild Cognitive Impairment or Dementia Only in APOE ɛ4 Allele Carriers
Kadey, KR., et al.
2021,
Journal of Alzheimer's disease: JAD
Longitudinal Body Weight Change, Visit-To-Visit Body Weight Fluctuation, and Cognitive Decline Among Older Adults
Lan, Y., et al.
2021,
NeuroImage. Clinical
A prospective cohort study of prodromal Alzheimer's disease: Prospective Imaging Study of Ageing: Genes, Brain and Behaviour (PISA)
Lupton, MK., et al.
2021,
Heart & Lung: The Journal of Critical Care
Testing influences of APOE and BDNF genes and heart failure on cognitive function
Jung, M., et al.
2021,
Methods in Molecular Biology (Clifton, N.J.)
Using INFERNO to Infer the Molecular Mechanisms Underlying Noncoding Genetic Associations
Amlie-Wolf, A., et al.
2021,
Annals of Neurology
Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome
Andrews, SJ., et al.
2021,
Alzheimer's & Dementia (Amsterdam, Netherlands)
Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease
Xue, D., et al.
2020
2020,
Brain: A Journal of Neurology
rs34331204 regulates TSPAN13 expression and contributes to Alzheimer's disease with sex differences
Hu, Y., et al.
2020,
Neuromolecular Medicine
Transcriptomic Heterogeneity of Alzheimer's Disease Associated with Lipid Genetic Risk
Miao, X., et al.
2020,
Molecular Psychiatry
Genetic data and cognitively defined late-onset Alzheimer's disease subgroups
Mukherjee, S., et al.
2020,
Acta Neuropathologica
Distinct clinicopathologic clusters of persons with TDP-43 proteinopathy
Katsumata, Y., et al.
2020,
Human Molecular Genetics
Integrative genomics approach identifies conserved transcriptomic networks in Alzheimer's disease
Morabito, S., et al.
2020,
Acta Neuropathologica
ADNC-RS, a clinical-genetic risk score, predicts Alzheimer's pathology in autopsy-confirmed Parkinson's disease and Dementia with Lewy bodies
Dai, DL., et al.
2020,
Aging Cell
Underlying features of epigenetic aging clocks in vivo and in vitro
Liu, Z., et al.
2020,
JAMA network open
Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry
Blue, EE., et al.
2020,
Nature Genetics
An integrated multi-omics approach identifies epigenetic alterations associated with Alzheimer's disease
Nativio, R., et al.
2020,
Neurology
Physical activity and risk of Alzheimer disease: A 2-sample mendelian randomization study
Baumeister, SE., et al.
2020,
American Journal of Human Genetics
Evolution of a Human-Specific Tandem Repeat Associated with ALS
Course, MM., et al.
2020,
Alzheimer's Research & Therapy
Analysis of brain region-specific co-expression networks reveals clustering of established and novel genes associated with Alzheimer disease
Lancour, D., et al.
2020,
Cell Reports
Cross-Species Analyses Identify Dlgap2 as a Regulator of Age-Related Cognitive Decline and Alzheimer's Dementia
Ouellette, AR., et al.
2020,
Neurobiology of Aging
Degree of genetic liability for Alzheimer's disease associated with specific proteomic profiles in cerebrospinal fluid
Reus, LM., et al.
2020,
Neurobiology of Disease
Identification and genomic analysis of pedigrees with exceptional longevity identifies candidate rare variants
Miller, JB., et al.
2020,
Neurology. Genetics
Synonymous variants associated with Alzheimer disease in multiplex families
Tang, M., et al.
2020,
Brain: A Journal of Neurology
Reply: CYLD variants in frontotemporal dementia associated with severe memory impairment in a Portuguese cohort
Oyston, LJ., et al.
2020,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association study of rate of cognitive decline in Alzheimer's disease patients identifies novel genes and pathways
Sherva, R., et al.
2020,
Brain: A Journal of Neurology
Genetic variants and functional pathways associated with resilience to Alzheimer's disease
Dumitrescu, L., et al.
2020,
Molecular Psychiatry
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Bis, JC., et al.
2020,
Cell Reports
Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models
Wan, Y., et al.
2020,
Journal of the American Geriatrics Society
Interplay between Socioeconomic Markers and Polygenic Predisposition on Timing of Dementia Diagnosis
Ajnakina, O., et al.
2020,
Brain: A Journal of Neurology
Sex-dependent autosomal effects on clinical progression of Alzheimer's disease
Fan, CC., et al.
2020,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
MAPT haplotype-stratified GWAS reveals differential association for AD risk variants
Strickland, SL., et al.
2020,
Bioinformatics (Oxford, England)
SparkINFERNO: a scalable high-throughput pipeline for inferring molecular mechanisms of non-coding genetic variants
Kuksa, PP., et al.
2020,
Neurobiology of Aging
Failure to detect synergy between variants in transferrin and hemochromatosis and Alzheimer's disease in large cohort
Vance, E., et al.
2020,
Alzheimer's Research & Therapy
An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease
Gerring, ZF., et al.
2020,
Translational Psychiatry
Shared genetic etiology underlying Alzheimer's disease and major depressive disorder
Lutz, MW., et al.
2020,
Nature Communications
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study
Reiman, EM., et al.
2020,
Acta Neuropathologica
Overlapping genetic architecture between Parkinson disease and melanoma
Dube, U., et al.
2020,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study
Andrews, SJ., et al.
2020,
Journal of Alzheimer's disease: JAD
Whole-Exome Sequencing Analysis of Alzheimer's Disease in Non-APOE*4 Carriers
Fan, K., et al.
2020,
Journal of Alzheimer's disease: JAD
Characterizing Clinical and Neuropathological Traits of APOE Haplotypes in African Americans and Europeans
Mezlini, AM., et al.
2020,
Frontiers in Genetics
Recent Consanguinity and Outbred Autozygosity Are Associated With Increased Risk of Late-Onset Alzheimer's Disease
Napolioni, V., et al.
2020,
Journal of Alzheimer's disease: JAD
Examination of the Effect of Rare Variants in TREM2, ABI3, and PLCG2 in LOAD Through Multiple Phenotypes
Olive, C., et al.
2020,
Frontiers in Aging Neuroscience
Association of Genes Involved in the Metabolic Pathways of Amyloid-β and Tau Proteins With Sporadic Late-Onset Alzheimer's Disease in the Southern Han Chinese Population
Xiao, X., et al.
2020,
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Hadoop and PySpark for reproducibility and scalability of genomic sequencing studies
Wheeler, NR., et al.
2020,
Journal of Alzheimer's disease: JAD
Investigating Causal Relations Between Risk Tolerance, Risky Behaviors, and Alzheimer's Disease: A Bidirectional Two-Sample Mendelian Randomization Study
Yang, Y., et al.
2020,
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing
Packaging Biocomputing Software to Maximize Distribution and Reuse
Bush, WS., et al.
2020,
Journal of Alzheimer's disease: JAD
Impact of Vitamin D Binding Protein Levels on Alzheimer's Disease: A Mendelian Randomization Study
Zhang, H., et al.
2020,
Journal of Alzheimer's disease: JAD
Impact of Serum Calcium Levels on Alzheimer's Disease: A Mendelian Randomization Study
He, Y., et al.
2020,
Journal of Alzheimer's disease: JAD
Circulating Vitamin D Levels and Alzheimer's Disease: A Mendelian Randomization Study in the IGAP and UK Biobank
Wang, L., et al.
2020,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Two-stage Bayesian GWAS of 9576 individuals identifies SNP regions that are targeted by miRNAs inversely expressed in Alzheimer's and cancer
Pathak, GA., et al.
2020,
Journal of Neuropathology and Experimental Neurology
Alzheimer Disease Pathology-Associated Polymorphism in a Complex Variable Number of Tandem Repeat Region Within the MUC6 Gene, Near the AP2A2 Gene
Katsumata, Y., et al.
2020,
Genetic Epidemiology
Case-control versus case-only estimates of gene-environment interactions with common and misclassified clinical diagnosis
Lobach, I., et al.
2020,
Computational and Structural Biotechnology Journal
Benchmarking machine learning models for late-onset alzheimer's disease prediction from genomic data
De Velasco Oriol, J., et al.
2019,
International Journal of Epidemiology
Polygenic risk scores for Alzheimer's disease, and academic achievement, cognitive and behavioural measures in children from the general population
Korologou-Linden, R., et al.
2019,
Neurobiology of Aging
Identification of genetic heterogeneity of Alzheimer's disease across age
Lo, M., et al.
2019,
Scientific Reports
Genome Wide Meta-Analysis identifies common genetic signatures shared by heart function and Alzheimer's disease
Sáez, ME., et al.
2019,
Brain: A Journal of Neurology
Rs2293871 regulates HTRA1 expression and affects cerebral small vessel stroke and Alzheimer's disease
Liu, G., et al.
2019,
BMC cardiovascular disorders
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Schmidt, AF., et al.
2019,
Translational Psychiatry
Examining the association between genetic liability for schizophrenia and psychotic symptoms in Alzheimer's disease
Creese, B., et al.
2019,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project
Moreno-Grau, S., et al.
2019,
JAMA neurology
Analysis of Whole-Exome Sequencing Data for Alzheimer Disease Stratified by APOE Genotype
Ma, Y., et al.
2019,
Brain: A Journal of Neurology
Sex differences in the genetic predictors of Alzheimer's pathology
Dumitrescu, L., et al.
2019,
American Journal of Human Genetics
TIGAR: An Improved Bayesian Tool for Transcriptomic Data Imputation Enhances Gene Mapping of Complex Traits
Nagpal, S., et al.
2019,
Aging Cell
CpG-related SNPs in the MS4A region have a dose-dependent effect on risk of late-onset Alzheimer disease
Ma, Y., et al.
2019,
Neurobiology of Disease
Heritability and genetic variance of dementia with Lewy bodies
Guerreiro, R., et al.
2019,
Genomics
Quality control and integration of genotypes from two calling pipelines for whole genome sequence data in the Alzheimer's disease sequencing project
Naj, AC., et al.
2019,
Genetic Epidemiology
A simple approximation to bias in the genetic effect estimates when multiple disease states share a clinical diagnosis
Lobach, I., et al.
2019,
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease
Fleck, D., et al.
2019,
European Journal of Epidemiology
Blood-brain barrier transcytosis genes, risk of dementia and stroke: a prospective cohort study of 74,754 individuals
Juul Rasmussen, I., et al.
2019,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Novel methods for integration and visualization of genomics and genetics data in Alzheimer's disease
Bihlmeyer, NA., et al.
2019,
Translational Psychiatry
Alzheimer's disease polygenic risk score as a predictor of conversion from mild-cognitive impairment
Chaudhury, S., et al.
2019,
Nature Communications
Epigenetic dysregulation of enhancers in neurons is associated with Alzheimer's disease pathology and cognitive symptoms
Li, P., et al.
2019,
Genome Biology
Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight
Ebbert, MTW., et al.
2019,
Bioinformatics (Oxford, England)
VCPA: genomic variant calling pipeline and data management tool for Alzheimer's Disease Sequencing Project
Leung, YY., et al.
2019,
European journal of human genetics: EJHG
Comparison of methods for multivariate gene-based association tests for complex diseases using common variants
Chung, J., et al.
2019,
Bioinformatics (Oxford, England)
DASHR 2.0: integrated database of human small non-coding RNA genes and mature products
Kuksa, PP., et al.
2019,
JAMA network open
Association of Rare Coding Mutations With Alzheimer Disease and Other Dementias Among Adults of European Ancestry
Patel, D., et al.
2019,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease
Zhang, X., et al.
2019,
Nature Genetics
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Kunkle, BW., et al.
2019,
Nature Genetics
A statistical framework for cross-tissue transcriptome-wide association analysis
Hu, Y., et al.
2019,
Acta Neuropathologica
Dissecting the genetic relationship between cardiovascular risk factors and Alzheimer's disease
Broce, IJ., et al.
2019,
Neurobiology of Aging
Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs
Katsumata, Y., et al.
2019,
Neuropathology and Applied Neurobiology
Is APOE ε4 required for Alzheimer's disease to develop in TREM2 p.R47H variant carriers?
Guerreiro, R., et al.
2019,
Frontiers in Genetics
A Simple Approximation to Bias in Gene-Environment Interaction Estimates When a Case Might Not Be the Case
Lobach, I., et al.
2019,
Frontiers in Neuroscience
Genetic Overlap Between Alzheimer's Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
Drange, OK., et al.
2019,
The American Journal of Clinical Nutrition
Circulating antioxidants and Alzheimer disease prevention: a Mendelian randomization study
Williams, DM., et al.
2019,
PloS One
Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease
Baker, E., et al.
2019,
Wellcome Open Research
Polygenic risk score for Alzheimer's disease and trajectories of cardiometabolic risk factors in children
Korologou-Linden, R., et al.
2019,
Frontiers in Genetics
Polygenic Risk Score for Alzheimer's Disease Is Associated With Ch4 Volume in Normal Subjects
Wang, T., et al.
2019,
Alzheimer's & Dementia (New York, N. Y.)
Estrogen activates Alzheimer's disease genes
Ratnakumar, A., et al.
2019,
Journal of Alzheimer's disease: JAD
Inferring the Molecular Mechanisms of Noncoding Alzheimer's Disease-Associated Genetic Variants
Amlie-Wolf, A., et al.
2018
2018,
Scientific Reports
Meta-analysis of Alzheimer's disease on 9,751 samples from Norway and IGAP study identifies four risk loci
Witoelar, A., et al.
2018,
PLoS genetics
Ancestral origin of ApoE ε4 Alzheimer disease risk in Puerto Rican and African American populations
Rajabli, F., et al.
2018,
Neurobiology of Aging
Male-specific epistasis between WWC1 and TLN2 genes is associated with Alzheimer's disease
Gusareva, ES., et al.
2018,
Aging Medicine (Milton (N.S.W))
Systemic inflammation and causal risk for Alzheimer's dementia: Possibilities and limitations of a Mendelian randomization approach
Tsui, A.
2018,
Neurology. Genetics
Rare genetic variation implicated in non-Hispanic white families with Alzheimer disease
Beecham, GW., et al.
2018,
Acta Neuropathologica
Sex-specific genetic predictors of Alzheimer's disease biomarkers
Deming, Y., et al.
2018,
Genetic Epidemiology
Bias in parameter estimates due to omitting gene-environment interaction terms in case-control studies
Lobach, I.
2018,
Scientific Reports
Systematic Analysis and Biomarker Study for Alzheimer's Disease
Li, X., et al.
2018,
Nucleic Acids Research
INFERNO: inferring the molecular mechanisms of noncoding genetic variants
Amlie-Wolf, A., et al.
2018,
Bioinformatics (Oxford, England)
Functional annotation of genomic variants in studies of late-onset Alzheimer's disease
Butkiewicz, M., et al.
2018,
Neuropathology and Applied Neurobiology
Whole-exome sequencing of the BDR cohort: evidence to support the role of the PILRA gene in Alzheimer's disease
Patel, T., et al.
2018,
Nature Neuroscience
Cell-specific histone modification maps in the human frontal lobe link schizophrenia risk to the neuronal epigenome
Girdhar, K., et al.
2018,
JAMA neurology
Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau
Hohman, TJ., et al.
2018,
Bioinformatics (Oxford, England)
Integrative DNA copy number detection and genotyping from sequencing and array-based platforms
Zhou, Z., et al.
2018,
Neuron
Multiscale Analysis of Independent Alzheimer's Cohorts Finds Disruption of Molecular, Genetic, and Clinical Networks by Human Herpesvirus
Readhead, B., et al.
2018,
Nucleic Acids Research
SPAR: small RNA-seq portal for analysis of sequencing experiments
Kuksa, PP., et al.
2018,
JAMA neurology
Selective Genetic Overlap Between Amyotrophic Lateral Sclerosis and Diseases of the Frontotemporal Dementia Spectrum
Karch, CM., et al.
2018,
Genes, Brain, and Behavior
Variants regulating ZBTB4 are associated with age-at-onset of Alzheimer's disease
Blue, EE., et al.
2018,
Annals of Clinical and Translational Neurology
Whole-exome sequencing in 20,197 persons for rare variants in Alzheimer's disease
Raghavan, NS., et al.
2018,
Journal of Neuroimmune Pharmacology: The Official Journal of the Society on NeuroImmune Pharmacology
Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans
Ikezu, T., et al.
2018,
Stroke
Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia
Rutten-Jacobs, LCA., et al.
2018,
Experimental Gerontology
Genetically elevated gamma-glutamyltransferase and Alzheimer's disease
Kunutsor, SK., et al.
2018,
Human Molecular Genetics
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study
Teslovich, TM., et al.
2018,
Annals of Clinical and Translational Neurology
Whole genome sequencing of Caribbean Hispanic families with late-onset Alzheimer's disease
Vardarajan, BN., et al.
2018,
PLoS genetics
One for all and all for One: Improving replication of genetic studies through network diffusion
Lancour, D., et al.
2018,
BMC medicine
Genetic variation in clusterin and risk of dementia and ischemic vascular disease in the general population: cohort studies and meta-analyses of 362,338 individuals
Nordestgaard, LT., et al.
2018,
American Journal of Human Genetics
Comprehensive Analysis of Constraint on the Spatial Distribution of Missense Variants in Human Protein Structures
Sivley, RM., et al.
2018,
Alzheimer's Research & Therapy
Genome-wide pleiotropy analysis of neuropathological traits related to Alzheimer's disease
Chung, J., et al.
2018,
Proceedings of the National Academy of Sciences of the United States of America
Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer's disease pathogenesis
Zhou, X., et al.
2018,
Neurobiology of Aging
Polygenic risk score in postmortem diagnosed sporadic early-onset Alzheimer's disease
Chaudhury, S., et al.
2018,
Neurobiology of Aging
Genetic influence of plasma homocysteine on Alzheimer's disease
Roostaei, T., et al.
2018,
Gastroenterology
Exome-Wide Association Study of Pancreatic Cancer Risk
Grant, RC., et al.
2018,
American Journal of Alzheimer's Disease and Other Dementias
Val66Met Polymorphism in BDNF Has No Sexual and APOE ε4 Status-Based Dimorphic Effects on Susceptibility to Alzheimer's Disease: Evidence From an Updated Meta-Analysis of Case-Control Studies and High-Throughput Genotyping Cohorts
Zhao, Q., et al.
2018,
Neurology
Circulating insulin-like growth factors and Alzheimer disease: A mendelian randomization study
Williams, DM., et al.
2018,
Acta Neuropathologica
Polygenic hazard score: an enrichment marker for Alzheimer's associated amyloid and tau deposition
Tan, CH., et al.
2018,
Journal of Alzheimer's disease: JAD
The GWAS Risk Genes for Depression May Be Actively Involved in Alzheimer's Disease
Ni, H., et al.
2018,
PloS One
Episodic memory performance in a multi-ethnic longitudinal study of 13,037 elderly
Lee, S., et al.
2018,
PloS One
Case-control studies of gene-environment interactions. When a case might not be the case
Lobach, I., et al.
2018,
Dementia and Geriatric Cognitive Disorders
Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project
Blue, EE., et al.
2017
2017,
eLife
Neuropathological and transcriptomic characteristics of the aged brain
Miller, JA., et al.
2017,
Molecular Neurodegeneration
Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer's disease
McKenzie, AT., et al.
2017,
PLoS genetics
Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease
Fernández, MV., et al.
2017,
Genome Biology
McEnhancer: predicting gene expression via semi-supervised assignment of enhancers to target genes
Hafez, D., et al.
2017,
Scientific Reports
Branched-chain amino acids and Alzheimer's disease: a Mendelian randomization analysis
Larsson, SC.
2017,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Systems biology approach to late-onset Alzheimer's disease genome-wide association study identifies novel candidate genes validated using brain expression data and Caenorhabditis elegans experiments
Mukherjee, S., et al.
2017,
Human Genetics
Investigating the genetic relationship between Alzheimer's disease and cancer using GWAS summary statistics
Feng, YA., et al.
2017,
Neurology. Genetics
The Alzheimer's Disease Sequencing Project: Study design and sample selection
Beecham, GW., et al.
2017,
JAMA neurology
Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease: A Meta-analysis
Neu, SC., et al.
2017,
JAMA neurology
Early-Onset Alzheimer Disease and Candidate Risk Genes Involved in Endolysosomal Transport
Kunkle, BW., et al.
2017,
Annals of Neurology
Polygenic hazard scores in preclinical Alzheimer disease
Tan, CH., et al.
2017,
Nature Genetics
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Sims, R., et al.
2017,
Nature Neuroscience
A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease
Huang, K., et al.
2017,
Journal of Alzheimer's Disease & Parkinsonism
Exome Sequencing of Extended Families with Alzheimer's Disease Identifies Novel Genes Implicated in Cell Immunity and Neuronal Function
Cukier, HN., et al.
2017,
The Journal of Clinical Endocrinology and Metabolism
Body Mass Index and Risk of Alzheimer's Disease: A Mendelian Randomization Study of 399,536 Individuals
Nordestgaard, LT., et al.
2017,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Transethnic genome-wide scan identifies novel Alzheimer's disease loci
Jun, GR., et al.
2017,
Acta Neuropathologica
Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism
Chapuis, J., et al.
2017,
Translational Psychiatry
Genetic susceptibility to cardiovascular disease and risk of dementia
Karlsson, IK., et al.
2017,
Acta Neuropathologica
Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers
Deming, Y., et al.
2017,
Nature Communications
Genetic correlation between amyotrophic lateral sclerosis and schizophrenia
McLaughlin, RL., et al.
2017,
PLoS medicine
Fine-mapping of the human leukocyte antigen locus as a risk factor for Alzheimer disease: A case-control study
Steele, NZR., et al.
2017,
PLoS medicine
Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score
Desikan, RS., et al.
2017,
Journal of Neurology, Neurosurgery, and Psychiatry
Genetic architecture of sporadic frontotemporal dementia and overlap with Alzheimer's and Parkinson's diseases
Ferrari, R., et al.
2017,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
Mez, J., et al.
2017,
Journal of Alzheimer's disease: JAD
A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains
Haddick, PCG., et al.
2017,
Journal of Alzheimer's disease: JAD
Implication of the APP Gene in Intellectual Abilities
Myrum, C., et al.
2017,
Journal of Alzheimer's disease: JAD
Genetically-Predicted Adult Height and Alzheimer's Disease
Larsson, SC., et al.
2017,
PloS One
Caspase-8, association with Alzheimer's Disease and functional analysis of rare variants
Rehker, J., et al.
2017,
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics
Genomic variants, genes, and pathways of Alzheimer's disease: An overview
Naj, AC., et al.
2017,
Journal of Alzheimer's disease: JAD
The Correlation between Inflammatory Biomarkers and Polygenic Risk Score in Alzheimer's Disease
Morgan, AR., et al.
2017,
Journal of Alzheimer's disease: JAD
Risk Factors and Pathological Substrates Associated with Agitation/Aggression in Alzheimer's Disease: A Preliminary Study using NACC Data
Sennik, S., et al.
2017,
Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals
Ighodaro, ET., et al.
2017,
The Clinical Neuropsychologist
Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease
LoBue, C., et al.
2017,
Alzheimer Disease and Associated Disorders
Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology
Monsell, SE., et al.
2017,
Methods in Molecular Biology (Clifton, N.J.)
In Silico Identification of RNA Modifications from High-Throughput Sequencing Data Using HAMR
Kuksa, PP., et al.
2016
2016,
Neurology
Genetically decreased vitamin D and risk of Alzheimer disease
Mokry, LE., et al.
2016,
Acta Neuropathologica
Genomics and CSF analyses implicate thyroid hormone in hippocampal sclerosis of aging
Nelson, PT., et al.
2016,
Nature Neuroscience
Novel genetic loci underlying human intracranial volume identified through genome-wide association
Adams, HHH., et al.
2016,
Annals of Clinical and Translational Neurology
Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases
Gagliano, SA., et al.
2016,
Neurology. Genetics
SORL1 mutations in early- and late-onset Alzheimer disease
Cuccaro, ML., et al.
2016,
BMC neurology
Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40
Deming, Y., et al.
2016,
Annals of Clinical and Translational Neurology
Age-dependent effects of APOE ε4 in preclinical Alzheimer's disease
Bonham, LW., et al.
2016,
Nature Genetics
NEK1 variants confer susceptibility to amyotrophic lateral sclerosis
Kenna, KP., et al.
2016,
Biological Psychiatry
Genetic Markers of Human Evolution Are Enriched in Schizophrenia
Srinivasan, S., et al.
2016,
Molecular Neurobiology
PLD3 in Alzheimer's Disease: a Modest Effect as Revealed by Updated Association and Expression Analyses
Zhang, D., et al.
2016,
Nature Genetics
Detection and interpretation of shared genetic influences on 42 human traits
Pickrell, JK., et al.
2016,
BMC genomics
Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels
Ebbert, MTW., et al.
2016,
BMC genomics
Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid
Staley, LA., et al.
2016,
BMC genomics
Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels
Staley, LA., et al.
2016,
Neurology. Genetics
ABCA7 frameshift deletion associated with Alzheimer disease in African Americans
Cukier, HN., et al.
2016,
Science Translational Medicine
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Scott, RA., et al.
2016,
JAMA neurology
Association Between Genetic Traits for Immune-Mediated Diseases and Alzheimer Disease
Yokoyama, JS., et al.
2016,
BMC bioinformatics
A comprehensive database of high-throughput sequencing-based RNA secondary structure probing data (Structure Surfer)
Berkowitz, ND., et al.
2016,
Genome Medicine
Identification of the BRD1 interaction network and its impact on mental disorder risk
Fryland, T., et al.
2016,
Neurobiology of Aging
The executive prominent/memory prominent spectrum in Alzheimer's disease is highly heritable
Mez, J., et al.
2016,
Neurobiology of Aging
Assessment of the genetic variance of late-onset Alzheimer's disease
Ridge, PG., et al.
2016,
Neurobiology of Aging
The effect of increased genetic risk for Alzheimer's disease on hippocampal and amygdala volume
Lupton, MK., et al.
2016,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk
Hohman, TJ., et al.
2016,
Neurobiology of Aging
Discovery of gene-gene interactions across multiple independent data sets of late onset Alzheimer disease from the Alzheimer Disease Genetics Consortium
Hohman, TJ., et al.
2016,
Neurology. Genetics
Segregation of a rare TTC3 variant in an extended family with late-onset Alzheimer disease
Kohli, MA., et al.
2016,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Interaction between variants in CLU and MS4A4E modulates Alzheimer's disease risk
Ebbert, MTW., et al.
2016,
Scientific Reports
Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
Deming, Y., et al.
2016,
Nucleic Acids Research
DASHR: database of small human noncoding RNAs
Leung, YY., et al.
2016,
Journal of Alzheimer's disease: JAD
Self-Reported Traumatic Brain Injury and Mild Cognitive Impairment: Increased Risk and Earlier Age of Diagnosis
LoBue, C., et al.
2016,
Alzheimer Disease and Associated Disorders
Diabetic Phenotypes and Late-Life Dementia Risk: A Mechanism-specific Mendelian Randomization Study
Walter, S., et al.
2016,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease
Kunkle, BW., et al.
2016,
Neurobiology of Aging
A potential endophenotype for Alzheimer's disease: cerebrospinal fluid clusterin
Deming, Y., et al.
2016,
Molecular Psychiatry
A novel Alzheimer disease locus located near the gene encoding tau protein
Jun, G., et al.
2016,
PloS One
Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci
Karch, CM., et al.
2015
2015,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease
Barral, S., et al.
2015,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses
Mukherjee, S., et al.
2015,
Brain: A Journal of Neurology
Common polygenic variation enhances risk prediction for Alzheimer's disease
Escott-Price, V., et al.
2015,
Molecular Psychiatry
Genetic overlap between Alzheimer's disease and Parkinson's disease at the MAPT locus
Desikan, RS., et al.
2015,
Nature Genetics
An atlas of genetic correlations across human diseases and traits
Bulik-Sullivan, B., et al.
2015,
JAMA neurology
Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals
Ghani, M., et al.
2015,
JAMA psychiatry
Genetic Analysis of Association Between Calcium Signaling and Hippocampal Activation, Memory Performance in the Young and Old, and Risk for Sporadic Alzheimer Disease
Heck, A., et al.
2015,
Neurology. Genetics
Late-onset Alzheimer disease risk variants mark brain regulatory loci
Allen, M., et al.
2015,
Human Molecular Genetics
Genetics of CD33 in Alzheimer's disease and acute myeloid leukemia
Malik, M., et al.
2015,
Circulation
Polygenic Overlap Between C-Reactive Protein, Plasma Lipids, and Alzheimer Disease
Desikan, RS., et al.
2015,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Convergent genetic and expression data implicate immunity in Alzheimer's disease
International Genomics of Alzheimer's Disease Consortium (IGAP), .
2015,
PLoS medicine
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
Østergaard, SD., et al.
2015,
Journal of Computational Biology: A Journal of Computational Molecular Cell Biology
PASTA: Ultra-Large Multiple Sequence Alignment for Nucleotide and Amino-Acid Sequences
Mirarab, S., et al.
2015,
Bioinformatics (Oxford, England)
HIPPIE: a high-throughput identification pipeline for promoter interacting enhancer elements
Hwang, Y., et al.
2015,
Neurology
PARK10 is a major locus for sporadic neuropathologically confirmed Parkinson disease
Beecham, GW., et al.
2015,
JAMA neurology
Rarity of the Alzheimer disease-protective APP A673T variant in the United States
Wang, L., et al.
2015,
Journal of Neuropathology and Experimental Neurology
Reassessment of risk genotypes (GRN, TMEM106B, and ABCC9 variants) associated with hippocampal sclerosis of aging pathology
Nelson, PT., et al.
2015,
PloS One
Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin
Amlie-Wolf, A., et al.
2014
2014,
Human Molecular Genetics
SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease
Ramirez, A., et al.
2014,
Nature Medicine
A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death
Wetzel-Smith, MK., et al.
2014,
JAMA neurology
Common genetic variants on 6q24 associated with exceptional episodic memory performance in the elderly
Barral, S., et al.
2014,
Neurobiology of Aging
Genetic variants in a 'cAMP element binding protein' (CREB)-dependent histone acetylation pathway influence memory performance in cognitively healthy elderly individuals
Barral, S., et al.
2014,
JAMA neurology
Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study
Naj, AC., et al.
2014,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans
Logue, MW., et al.
2014,
PLoS genetics
Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation
Kauwe, JSK., et al.
2014,
PLoS genetics
Genome-wide association meta-analysis of neuropathologic features of Alzheimer's disease and related dementias
Beecham, GW., et al.
2014,
Annals of Neurology
PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation
Jun, G., et al.
2014,
Neurobiology of Aging
Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways
Logue, MW., et al.
2014,
Neurobiology of Aging
Missense variant in TREML2 protects against Alzheimer's disease
Benitez, BA., et al.
2014,
Methods (San Diego, Calif.)
Using machine learning and high-throughput RNA sequencing to classify the precursors of small non-coding RNAs
Ryvkin, P., et al.
2014,
Translational Psychiatry
Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene
Ruiz, A., et al.
2014,
PloS One
Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Escott-Price, V., et al.
2014,
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
Genome-wide association study of the rate of cognitive decline in Alzheimer's disease
Sherva, R., et al.
2014,
Acta Neuropathologica
ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology
Nelson, PT., et al.
2014,
Alzheimer's Research & Therapy
Association of MAPT haplotypes with Alzheimer's disease risk and MAPT brain gene expression levels
Allen, M., et al.
2013
2013,
Nature Genetics
Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Lambert, JC., et al.
2013,
RNA (New York, N.Y.)
HAMR: high-throughput annotation of modified ribonucleotides
Ryvkin, P., et al.
2013,
Current Protocols in Human Genetics
Analyzing copy number variation using SNP array data: protocols for calling CNV and association tests
Lin, C., et al.
2013,
The New England Journal of Medicine
TREM2 and neurodegenerative disease
Reitz, C., et al.
2013,
Bioinformatics (Oxford, England)
DRAW+SneakPeek: analysis workflow and quality metric management for DNA-seq experiments
Lin, C., et al.
2013,
Nucleic Acids Research
CoRAL: predicting non-coding RNAs from small RNA-sequencing data
Leung, YY., et al.
2013,
Translational Psychiatry
Independent and epistatic effects of variants in VPS10-d receptors on Alzheimer disease risk and processing of the amyloid precursor protein (APP)
Reitz, C., et al.
2013,
Nucleic Acids Research
High-throughput identification of long-range regulatory elements and their target promoters in the human genome
Hwang, Y., et al.
2013,
Neuron
GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease
Cruchaga, C., et al.
2013,
JAMA
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans
Reitz, C., et al.
2013,
Annals of Human Genetics
Initial assessment of the pathogenic mechanisms of the recently identified Alzheimer risk Loci
Holton, P., et al.
2013,
PloS One
Alzheimer's disease: analyzing the missing heritability
Ridge, PG., et al.
2013,
PloS One
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
Miyashita, A., et al.
2012
2012,
Nature Genetics
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
Whitcomb, DC., et al.
2012,
Human Molecular Genetics
Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease
Cruchaga, C., et al.
2012,
Archives of Neurology
Comprehensive search for Alzheimer disease susceptibility loci in the APOE region
Jun, G., et al.
2012,
Neurobiology of Aging
Identification of Alzheimer disease-associated variants in genes that regulate retromer function
Vardarajan, BN., et al.
2012,
Current Alzheimer Research
Analysis of copy number variation in Alzheimer's disease: the NIALOAD/ NCRAD Family Study
Swaminathan, S., et al.
2012,
Neurology
Novel late-onset Alzheimer disease loci variants associate with brain gene expression