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2025

2025,  
medRxiv: The Preprint Server for Health Sciences

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Fang, Z., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

APOE ε 4 -Associated Hippocampal Atrophy Trajectories Across the Alzheimer's Disease Continuum: A Systematic Review, Meta-Analysis, and Longitudinal Validation

Cai, M., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

Proteomic profiling of Alzheimer's disease and Vascular dementia reveals unique underlying signatures

Amin, N., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

APOE*4 Risk-Modifying Genes and Drug Targets in Alzheimer's Disease through Cell-Type Specific Genomic Analyses

Zeng, Y., et al.
2025,  
Journal of Alzheimer's disease: JAD

Genetic association analyses of cognitive performance across multi-ancestry older adults: Application of Tobit models

Wu, X., et al.
2025,  
Neurobiology of Aging

Multi-omic derived cell-type specific Alzheimer disease polygenic risk scores

O'Neill, N., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's disease risk prediction

Venkatesh, R., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The role of genomic-informed risk assessments in predicting dementia outcomes

Andrews, SJ., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B

Godrich, D., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Alzheimer's disease multi-ancestry genome-wide interaction and stratified study with smoking

Dacey, R., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

Cross-Ancestry Polygenic Risk Scores Enhance Alzheimer's Disease Risk Prediction in Multiethnic Cohorts

Okorie, M., et al.
2025,  
bioRxiv: The Preprint Server for Biology

Beyond P-values: A Multi-Metric Framework for Robust Feature Selection and Predictive Modeling

Chen, R., et al.
2025,  
Bioinformatics (Oxford, England)

BTS: a scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across >1000s of omics datasets

Kuksa, PP., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Novel differentially expressed genes and multiple biological pathways for Alzheimer's disease identified in brain tissue from African American donors

Logue, MW., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

TAS2R38-Linked MGAM Expression in Alzheimer's Disease: A Novel Target for Precision Drug Repurposing

Su, CW., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Genome-wide pleiotropy analysis of longitudinal blood pressure and harmonized cognitive performance measures

Kang, M., et al.
2025,  
Scientific Reports

Integration of multi-omics quantitative trait loci evidence reveals novel susceptibility genes for Alzheimer's disease

Gao, J., et al.
2025,  
Brain: A Journal of Neurology

Novel modelling approaches to elucidate the genetic architecture of resilience to Alzheimer's disease

Phillips, JM., et al.
2025,  
Alzheimer's Research & Therapy

Genome-wide association studies of Alzheimer's disease and related disorders stratified by sex, onset age, and Apolipoprotein E genotype reveal novel risk loci in African Americans

Sherva, R., et al.
2025,  
Genome Biology

Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies known and novel cross-population and ancestry-specific associations as novel risk loci for Alzheimer's disease

Rajabli, F., et al.
2025,  
bioRxiv: The Preprint Server for Biology

Multiple-testing corrections in case-control studies using identity-by-descent segments

Temple, SD., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Exploring potential mechanisms of an African protective locus for Alzheimer's disease in APOEε4 carriers

Bertholim-Nasciben, L., et al.
2025,  
Research Square

Genetics of PLCG2 expression and splicing relative to Alzheimer's disease risk

Turner, AK., et al.
2025,  
International Journal of Molecular Sciences

Dysregulation of Inositol Polyphosphate 5-Phosphatase OCRL in Alzheimer's Disease: Implications for Autophagy Dysfunction

Ando, K., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

Integrative multi-omics approaches identify molecular pathways and improve Alzheimer's Disease risk prediction

Venkatesh, R., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

Sex-Specific Genetic Drivers of Memory, Executive Functioning, and Language Performance in Older Adults

Eissman, JM., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

NIAGADS: A data repository for Alzheimer's disease and related dementia genomics

Kuzma, A., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

The dynamics of cognitive decline toward Alzheimer's disease progression: Results from ADSP-PHC's harmonized cognitive composites

Kang, K., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracellular signaling pathways

Bradley, J., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia

Vattathil, SM., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Structural variation detection and association analysis of whole-genome-sequence data from 16,543 Alzheimer's disease sequencing project subjects

Wang, H., et al.
2025,  
bioRxiv: The Preprint Server for Biology

Sequencing the gaps: dark genomic regions persist in CHM13 despite long-read advances

Wadsworth, ME., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Alzheimer's Disease Sequencing Project release 4 whole genome sequencing dataset

Leung, YY., et al.
2025,  
Acta Neuropathologica

LATE-NC Stage 3: a diagnostic rubric to differentiate severe LATE-NC from FTLD-TDP

Shahidehpour, RK., et al.
2025,  
Alzheimer's Research & Therapy

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease

Kitani, A., et al.
2025,  
Neurology. Genetics

Whole Genome Variable Number Tandem Repeat Analysis in Alzheimer Disease

Heath, A., et al.
2025,  
Research Square

Sex-specific Associations of Gene Expression with Alzheimer's Disease Neuropathology and Ante-mortem Cognitive Performance

Dumitrescu, L., et al.
2025,  
Movement Disorders: Official Journal of the Movement Disorder Society

Copy Number Variation and Haplotype Analysis of 17q21.31 Reveals Increased Risk Associated with Progressive Supranuclear Palsy and Gene Expression Changes in Neuronal Cells

Wang, H., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

Leveraging multimodal neuroimaging and GWAS for identifying modality-level causal pathways to Alzheimer's disease

Tian, Y., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Distinct medical and substance use histories associate with cognitive decline in Alzheimer's disease

Mansel, C., et al.
2025,  
PLoS genetics

Local genetic covariance analysis with lipid traits identifies novel loci for early-onset Alzheimer's Disease

Ray, NR., et al.
2025,  
Nature Communications

Individual bioenergetic capacity as a potential source of resilience to Alzheimer's disease

Arnold, M., et al.
2025,  
bioRxiv: The Preprint Server for Biology

BTS: scalable Bayesian Tissue Score for prioritizing GWAS variants and their functional contexts across omics data

Kuksa, PP., et al.
2025,  
Brain: A Journal of Neurology

Amyloid-β predominant Alzheimer's disease neuropathologic change

Kovacs, GG., et al.
2025,  
medRxiv: The Preprint Server for Health Sciences

GWAS links APOE to neuropsychiatric symptoms in mild cognitive impairment and dementia

Vattathil, SM., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Association of APOE alleles and polygenic profiles comprising APOE-TOMM40-APOC1 variants with Alzheimer's disease neuroimaging markers

Kulminski, AM., et al.
2025,  
Nature Communications

Polygenic burden of short tandem repeat expansions promotes risk for Alzheimer's disease

Guo, MH., et al.
2025,  
Alzheimer's & Dementia (New York, N. Y.)

LD-informed deep learning for Alzheimer's gene loci detection using WGS data

Jo, T., et al.
2025,  
Alzheimer's & Dementia: The Journal of the Alzheimer's Association

Sex and APOE ε4 allele differences in longitudinal white matter microstructure in multiple cohorts of aging and Alzheimer's disease

Peterson, A., et al.
2025,  
NPJ dementia

Integrated genomic analysis and CRISPRi implicates EGFR in Alzheimer's disease risk

Leung, YY., et al.