Title | Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM |
Corporate Authors | collaborators of the Alzheimer's Disease Genetics Consortium |
Journal | Ann Neurol |
Volume | 89 |
Issue | 1 |
Pagination | 54-65 |
Date Published | 2021 01 |
ISSN | 1531-8249 |
Keywords | Aged, Aged, 80 and over, Alzheimer Disease, Amyloid beta-Peptides, Brain, Cholesterol, Cognition, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Neurofibrillary Tangles, Peptide Fragments, Risk Factors, Sleep |
Abstract | OBJECTIVE: The purpose of this study was to infer causal relationships between 22 previously reported risk factors for Alzheimer's disease (AD) and the "AD phenome": AD, AD age of onset (AAOS), hippocampal volume, cortical surface area and thickness, cerebrospinal fluid (CSF) levels of amyloid-β (Aβ ), tau, and ptau , and the neuropathological burden of neuritic plaques, neurofibrillary tangles (NFTs), and vascular brain injury (VBI). |
DOI | 10.1002/ana.25918 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/32996171?dopt=Abstract |
page_expo | External |
Alternate Journal | Ann Neurol |
PubMed ID | 32996171 |
PubMed Central ID | PMC8088901 |
Grant List | RC2 AG036528 / AG / NIA NIH HHS / United States U24 AG021886 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States U24 AG056270 / AG / NIA NIH HHS / United States K99 AG070109 / AG / NIA NIH HHS / United States U24 AG041689 / AG / NIA NIH HHS / United States R01 MH122866 / MH / NIMH NIH HHS / United States MR/N015746/1 / MRC_ / Medical Research Council / United Kingdom U01 AG058635 / AG / NIA NIH HHS / United States U01 AG052411 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States |
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