Title | Associating Multi-Modal Brain Imaging Phenotypes and Genetic Risk Factors via a Dirty Multi-Task Learning Method. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Du L, Liu F, Liu K, Yao X, Risacher SL, Han J, Saykin AJ, Shen L |
Journal | IEEE Trans Med Imaging |
Volume | 39 |
Issue | 11 |
Pagination | 3416-3428 |
Date Published | 2020 11 |
ISSN | 1558-254X |
Keywords | Algorithms, Alzheimer Disease, Brain, Humans, Neuroimaging, Phenotype, Polymorphism, Single Nucleotide, Risk Factors |
Abstract | Brain imaging genetics becomes more and more important in brain science, which integrates genetic variations and brain structures or functions to study the genetic basis of brain disorders. The multi-modal imaging data collected by different technologies, measuring the same brain distinctly, might carry complementary information. Unfortunately, we do not know the extent to which the phenotypic variance is shared among multiple imaging modalities, which further might trace back to the complex genetic mechanism. In this paper, we propose a novel dirty multi-task sparse canonical correlation analysis (SCCA) to study imaging genetic problems with multi-modal brain imaging quantitative traits (QTs) involved. The proposed method takes advantages of the multi-task learning and parameter decomposition. It can not only identify the shared imaging QTs and genetic loci across multiple modalities, but also identify the modality-specific imaging QTs and genetic loci, exhibiting a flexible capability of identifying complex multi-SNP-multi-QT associations. Using the state-of-the-art multi-view SCCA and multi-task SCCA, the proposed method shows better or comparable canonical correlation coefficients and canonical weights on both synthetic and real neuroimaging genetic data. In addition, the identified modality-consistent biomarkers, as well as the modality-specific biomarkers, provide meaningful and interesting information, demonstrating the dirty multi-task SCCA could be a powerful alternative method in multi-modal brain imaging genetics. |
DOI | 10.1109/TMI.2020.2995510 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/32746095?dopt=Abstract |
page_expo | Internal |
Alternate Journal | IEEE Trans Med Imaging |
PubMed ID | 32746095 |
PubMed Central ID | PMC7705646 |
Grant List | R01 AG019771 / AG / NIA NIH HHS / United States P30 AG010133 / AG / NIA NIH HHS / United States U01 AG024904 / AG / NIA NIH HHS / United States U01 AG068057 / AG / NIA NIH HHS / United States / / CIHR / Canada RF1 AG063481 / AG / NIA NIH HHS / United States R01 EB022574 / EB / NIBIB NIH HHS / United States U19 AG024904 / AG / NIA NIH HHS / United States |
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