Description
Data Available
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00147) in the “Choose a Dataset” section.
Once approved, you will be able to log in and access the data within the DARM portal.
Description
The ANGI GWAS dataset includes demographics, APOE genotype, and GWAS data for participants from the ANGI cohort. This dataset also includes amyloid PET scan results (positive, negative, uninterpretable, not yet reported), level of cognitive impairment (no impairment, MCI, Dementia), year of onset of cognitive impairment, most etiological causes of impairment (pre and post scan), year enrolled in IDEAS, year of amyloid PET scan, year of post-PET visit, MMSE score, and type of MCI (if applicable, amnestic or non-amnestic). Request additional ANGI data including IDEAS imaging and clinical data through the IDEAS website.
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| ANGI GWAS | snd10081 | Genotyping SNP Array | 1,647 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| ANGI: GWAS, Phenotype files | fsa000102 | NG00147.v1 | GWAS, Phenotypes |
View the File Manifest for a full list of files released in this dataset.
Subject Information
The first release includes quality controlled GWAS data on 1,647 participants from the ANGI cohort. It also includes phenotypes provided by the ANGI Study.
| Sample Set | Accession Number | Number of Subjects |
|---|---|---|
| ANGI GWAS | snd10081 | 1,647 |
Related Studies
Consent Levels
| Consent Level | Number of Subjects |
|---|---|
| GRU-IRB-PUB | 1,647 |
Visit the Data Use Limitations page for definitions of the consent levels above.
Acknowledgement
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00147.
For investigators using Amyloid Neuroimaging and Genetics Initiative (ANGI) (sa000049) data:
The ANGI study is supported by the Alzheimer’s Association Grant ANGI/IDEAS-17-497186. We thank the Alzheimer’s Association for their support and the ANGI study participants for their contribution to the study. We would also like to acknowledge the Imaging Dementia – Evidence for Amyloid Scanning Study (iDEAS) from whom amyloid imaging and other clinical data were obtained.
Related Publications
Rabinovici GD., Gatsonis C., et al. Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia. JAMA. 2019 Apr. doi: 10.1001/jama.2019.2000. PubMed link