Dataset

NG00071 - ADC7 - Alzheimer Disease Center Dataset 7

Overview

The NIA ADC cohort included subjects ascertained and evaluated by the clinical and neuropathology cores of the 39 past and present NIA-funded Alzheimer's Disease Centers (ADC).  Data collection is coordinated by the National Alzheimer’s Coordinating Center (NACC).  NACC coordinates collection of phenotype data from the ADCs, cleans all data, coordinates implementation of definitions of AD cases and controls, and coordinates collection of samples. Biological specimens are collected, stored, and distributed by the National Cell Repository for Alzheimer’s Disease (NCRAD).

This GWAS dataset, ADC7, is the seventh set of ADC genotyped subjects used by the Alzheimer's Disease Genetics Consortium (ADGC) to identify genes associated with an increased risk of developing late-onset Alzheimer’s disease (LOAD). The genomic dataset was first published in Kunkle et al. For deeper phenotypes, contact NACC.

The ADC7 sample set was genotyped using the Infinium HumanOmniExpressExome BeadChip, which captures genotype data on 964,193 genomic SNPs. This includes a selected subset of 273,246 functional exonic variants that heavily overlap with the variants genotyped on Illumina's previous exome chip array. As many exome chip association and genome-wide association analyses are performed separately, we have extracted the exonic variants into separate PLINK-formatted files from the remaining ~690,000 variants in order to facilitate ease of analysis, and simplifying combining files with overlapping marker sets (samples genotyped only on GWAS arrays or only on exome chip arrays). Quality control was performed separately for the genomic and exonic datasets. The exome chip data was first reported in the Sims et al. publication.

Detailed information about the dataset is provided in the following document: NG00071_ADC7_README.txt

Molecular Data Type

Disease

AD
Submission date: 
12/18/2018
Samples

Cases- 529
Controls- 706
MCI- 79
NA/Unknown- 148

Total- 1462

Phenotypes
Markers

628661

Platform