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Whole blood gene expression and white matter Hyperintensities.

TitleWhole blood gene expression and white matter Hyperintensities.
Publication TypeJournal Article
Year of Publication2017
AuthorsLin H, Satizabal C, Xie Z, Yang Q, Huan T, Joehanes R, Wen C, Munson PJ, Beiser A, Levy D, Seshadri S
JournalMol Neurodegener
Volume12
Issue1
Pagination67
Date Published2017 09 18
ISSN1750-1326
KeywordsAdult, Aged, Brain, Female, Humans, Male, Middle Aged, Prospective Studies, Transcriptome, White Matter
Abstract

BACKGROUND: White matter hyperintensities (WMH) are an important biomarker of cumulative vascular brain injury and have been associated with cognitive decline and an increased risk of dementia, stroke, depression, and gait impairments. The pathogenesis of white matter lesions however, remains uncertain. The characterization of gene expression profiles associated with WMH might help uncover molecular mechanisms underlying WMH.
METHODS: We performed a transcriptome-wide association study of gene expression profiles with WMH in 3248 participants from the Framingham Heart Study using the Affymetrix Human Exon 1.0 ST Array.
RESULTS: We identified 13 genes that were significantly associated with WMH (FDR < 0.05) after adjusting for age, sex and blood cell components. Many of these genes are involved in inflammation-related pathways.
CONCLUSION: Thirteen genes were significantly associated with WMH. Our study confirms the hypothesis that inflammation might be an important factor contributing to white matter lesions. Future work is needed to explore if these gene products might serve as potential therapeutic targets.

DOI10.1186/s13024-017-0209-5
Pubmed Linkhttps://www.ncbi.nlm.nih.gov/pubmed/28923099?dopt=Abstract
page_expoExternal
Alternate JournalMol Neurodegener
PubMed ID28923099
PubMed Central IDPMC5604498
Grant ListR01 NS017950 / NS / NINDS NIH HHS / United States
R01 AG054076 / AG / NIA NIH HHS / United States
HHSN268201500001C / HL / NHLBI NIH HHS / United States
R01 AG049607 / AG / NIA NIH HHS / United States
R01 AG008122 / AG / NIA NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
HHSN268201500001I / HL / NHLBI NIH HHS / United States
UH2 NS100605 / NS / NINDS NIH HHS / United States
U01 AG049505 / AG / NIA NIH HHS / United States

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