Title | A single-nuclei RNA sequencing study of Mendelian and sporadic AD in the human brain. |
Publication Type | Journal Article |
Year of Publication | 2019 |
Authors | Del-Aguila JL, Li Z, Dube U, Mihindukulasuriya KA, Budde JP, Fernández MVictoria, Ibañez L, Bradley J, Wang F, Bergmann K, Davenport R, Morris JC, Holtzman DM, Perrin RJ, Benitez BA, Dougherty J, Cruchaga C, Harari O |
Journal | Alzheimers Res Ther |
Volume | 11 |
Issue | 1 |
Pagination | 71 |
Date Published | 2019 08 09 |
ISSN | 1758-9193 |
Keywords | Aged, 80 and over, Alzheimer Disease, Atlases as Topic, Female, Gene Expression, Humans, Male, Microglia, Mutation, Neurons, Parietal Lobe, Presenilin-1, Sequence Analysis, RNA |
Abstract | BACKGROUND: Alzheimer's disease (AD) is the most common form of dementia. This neurodegenerative disorder is associated with neuronal death and gliosis heavily impacting the cerebral cortex. AD has a substantial but heterogeneous genetic component, presenting both Mendelian and complex genetic architectures. Using bulk RNA-seq from the parietal lobes and deconvolution methods, we previously reported that brains exhibiting different AD genetic architecture exhibit different cellular proportions. Here, we sought to directly investigate AD brain changes in cell proportion and gene expression using single-cell resolution. |
DOI | 10.1186/s13195-019-0524-x |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/31399126?dopt=Abstract |
page_expo | External |
Alternate Journal | Alzheimers Res Ther |
PubMed ID | 31399126 |
PubMed Central ID | PMC6689177 |
Grant List | R01 AG057777 / AG / NIA NIH HHS / United States P01 AG026276 / AG / NIA NIH HHS / United States R01AG057777 / GF / NIH HHS / United States P01 AG003991 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States |
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