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Innate sensing of mechanical properties of brain tissue by microglia.

TitleInnate sensing of mechanical properties of brain tissue by microglia.
Publication TypeJournal Article
Year of Publication2020
AuthorsAyata P, Schaefer A
JournalCurr Opin Immunol
Date Published2020 02
KeywordsAnimals, Brain, Foreign-Body Reaction, Humans, Immunity, Innate, Microglia, Neurons

External organic or inorganic objects (foreign bodies) that are inadvertently or purposefully placed in the human or animal tissues can trigger local tissue responses that aim at the elimination and/or segregation of foreign bodies from the tissue. The foreign body response (FBR) may have major implications for neurodegeneration associated with the formation of aberrant protein-based aggregates or plaques. The distinct physical features of the plaques, including high rigidity and varying surface properties, may trigger microglial mechanosensing of the plaque as a foreign body. The microglial FBR may have a dual function by promoting and/or suppressing the plaque driven neurodegeneration. Microglial contact with the plaque may trigger inflammatory activation of microglia and support microglia-driven neuronal damage. Conversely, persistent microglial activation may trigger the formation of a microglia-supported cell barrier that segregates and compacts the plaques thus preventing further plaque-induced damage to healthy neurons.

Pubmed Link
Alternate JournalCurr Opin Immunol
PubMed ID32058296
PubMed Central IDPMC7067639
Grant ListP01 DA047233 / DA / NIDA NIH HHS / United States
RF1 AG054011 / AG / NIA NIH HHS / United States
R21 MH115353 / MH / NIMH NIH HHS / United States
R01 MH118329 / MH / NIMH NIH HHS / United States
U01 AG058635 / AG / NIA NIH HHS / United States

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