Title | Innate sensing of mechanical properties of brain tissue by microglia. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Ayata P, Schaefer A |
Journal | Curr Opin Immunol |
Volume | 62 |
Pagination | 123-130 |
Date Published | 2020 02 |
ISSN | 1879-0372 |
Keywords | Animals, Brain, Foreign-Body Reaction, Humans, Immunity, Innate, Microglia, Neurons |
Abstract | External organic or inorganic objects (foreign bodies) that are inadvertently or purposefully placed in the human or animal tissues can trigger local tissue responses that aim at the elimination and/or segregation of foreign bodies from the tissue. The foreign body response (FBR) may have major implications for neurodegeneration associated with the formation of aberrant protein-based aggregates or plaques. The distinct physical features of the plaques, including high rigidity and varying surface properties, may trigger microglial mechanosensing of the plaque as a foreign body. The microglial FBR may have a dual function by promoting and/or suppressing the plaque driven neurodegeneration. Microglial contact with the plaque may trigger inflammatory activation of microglia and support microglia-driven neuronal damage. Conversely, persistent microglial activation may trigger the formation of a microglia-supported cell barrier that segregates and compacts the plaques thus preventing further plaque-induced damage to healthy neurons. |
DOI | 10.1016/j.coi.2020.01.003 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/32058296?dopt=Abstract |
page_expo | Internal |
Alternate Journal | Curr Opin Immunol |
PubMed ID | 32058296 |
PubMed Central ID | PMC7067639 |
Grant List | P01 DA047233 / DA / NIDA NIH HHS / United States RF1 AG054011 / AG / NIA NIH HHS / United States R21 MH115353 / MH / NIMH NIH HHS / United States R01 MH118329 / MH / NIMH NIH HHS / United States U01 AG058635 / AG / NIA NIH HHS / United States |
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