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Education differentially contributes to cognitive reserve across racial/ethnic groups.

TitleEducation differentially contributes to cognitive reserve across racial/ethnic groups.
Publication TypeJournal Article
Year of Publication2021
AuthorsAvila JF, Rentería MArce, Jones RN, Vonk JMJ, Turney I, Sol K, Seblova D, Arias F, Hill-Jarrett T, Levy S-A, Meyer O, Racine AM, Tom SE, Melrose RJ, Deters K, Medina LD, Carrión CI, Díaz-Santos M, Byrd DAR, Chesebro A, Colon J, Igwe KC, Maas B, Brickman AM, Schupf N, Mayeux R, Manly JJ
JournalAlzheimers Dement
Volume17
Issue1
Pagination70-80
Date Published2021 01
ISSN1552-5279
KeywordsAfrican Americans, Aged, Aged, 80 and over, Aging, Blacks, Brain, Cognitive Aging, Cognitive Reserve, Educational Status, Ethnicity, Female, Hispanic or Latino, Humans, Language, Magnetic Resonance Imaging, Male, Memory, Neuropsychological Tests, Racial Groups, White Matter, Whites
Abstract

INTRODUCTION: We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity.
METHODS: A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups.
RESULTS: Higher educational attainment attenuated the negative impact of WMH burden on memory (β = -0.03; 99% CI: -0.071, -0.002) and language decline (β = -0.024; 99% CI:- 0.044, -0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics.
DISCUSSION: Educational attainment does not contribute to CR similarly across racial/ethnic groups.
DOI10.1002/alz.12176
Pubmed Linkhttps://www.ncbi.nlm.nih.gov/pubmed/32827354?dopt=Abstract
page_expoExternal
Alternate JournalAlzheimers Dement
PubMed ID32827354
PubMed Central IDPMC8376080
Grant ListP30 AG059307 / AG / NIA NIH HHS / United States
UL1 TR001863 / TR / NCATS NIH HHS / United States
RF1 AG066107 / AG / NIA NIH HHS / United States
P01 AG007232 / AG / NIA NIH HHS / United States
RF1 AG054023 / AG / NIA NIH HHS / United States
R01 AG037212 / AG / NIA NIH HHS / United States
UL1 TR001873 / TR / NCATS NIH HHS / United States

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