Title | Early-Onset Alzheimer's Disease: What Is Missing in Research? |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Ayodele T, Rogaeva E, Kurup JT, Beecham G, Reitz C |
Journal | Curr Neurol Neurosci Rep |
Volume | 21 |
Issue | 2 |
Pagination | 4 |
Date Published | 2021 01 19 |
ISSN | 1534-6293 |
Keywords | Age of Onset, Aged, Alzheimer Disease, Amyloid beta-Protein Precursor, Humans, Mutation, Presenilin-1, Presenilin-2 |
Abstract | PURPOSE OF REVIEW: Early-onset Alzheimer's disease (EOAD), defined as Alzheimer's disease (AD) occurring before age 65, is significantly less well studied than the late-onset form (LOAD) despite EOAD often presenting with a more aggressive disease progression. The aim of this review is to summarize the current understanding of the etiology of EOAD, their translation into clinical practice, and to suggest steps to be taken to move our understanding forward. |
DOI | 10.1007/s11910-020-01090-y |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/33464407?dopt=Abstract |
page_expo | External |
Alternate Journal | Curr Neurol Neurosci Rep |
PubMed ID | 33464407 |
PubMed Central ID | PMC7815616 |
Grant List | U01 AG052410 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States RF1 AG054080 / AG / NIA NIH HHS / United States RF1 AG054074 / AG / NIA NIH HHS / United States R01 AG064614 / AG / NIA NIH HHS / United States |
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