Title | Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Armstrong NJ, Mather KA, Sargurupremraj M, Knol MJ, Malik R, Satizabal CL, Yanek LR, Wen W, Gudnason VG, Dueker ND, Elliott LT, Hofer E, Bis J, Jahanshad N, Li S, Logue MA, Luciano M, Scholz M, Smith AV, Trompet S, Vojinovic D, Xia R, Alfaro-Almagro F, Ames D, Amin N, Amouyel P, Beiser AS, Brodaty H, Deary IJ, Fennema-Notestine C, Gampawar PG, Gottesman R, Griffanti L, Jack CR, Jenkinson M, Jiang J, Kral BG, Kwok JB, Lampe L, Liewald DCM, Maillard P, Marchini J, Bastin ME, Mazoyer B, Pirpamer L, Romero JRafael, Roshchupkin GV, Schofield PR, Schroeter ML, Stott DJ, Thalamuthu A, Trollor J, Tzourio C, van der Grond J, Vernooij MW, Witte VA, Wright MJ, Yang Q, Morris Z, Siggurdsson S, Psaty B, Villringer A, Schmidt H, Haberg AK, van Duijn CM, J Jukema W, Dichgans M, Sacco RL, Wright CB, Kremen WS, Becker LC, Thompson PM, Mosley TH, Wardlaw JM, M Ikram A, Adams HHH, Seshadri S, Sachdev PS, Smith SM, Launer L, Longstreth W, DeCarli C, Schmidt R, Fornage M, Debette S, Nyquist PA |
Journal | Stroke |
Volume | 51 |
Issue | 7 |
Pagination | 2111-2121 |
Date Published | 2020 07 |
ISSN | 1524-4628 |
Keywords | Aged, Brain, Cerebral Small Vessel Diseases, Female, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Male, Middle Aged, White Matter |
Abstract | BACKGROUND AND PURPOSE: Periventricular white matter hyperintensities (WMH; PVWMH) and deep WMH (DWMH) are regional classifications of WMH and reflect proposed differences in cause. In the first study, to date, we undertook genome-wide association analyses of DWMH and PVWMH to show that these phenotypes have different genetic underpinnings. |
DOI | 10.1161/STROKEAHA.119.027544 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/32517579?dopt=Abstract |
page_expo | External |
Alternate Journal | Stroke |
PubMed ID | 32517579 |
PubMed Central ID | PMC7365038 |
Grant List | P41 EB015922 / EB / NIBIB NIH HHS / United States MC_QA137853 / MRC_ / Medical Research Council / United Kingdom MR/R024065/1 / MRC_ / Medical Research Council / United Kingdom MR/N027558/1 / MRC_ / Medical Research Council / United Kingdom U54 EB020403 / EB / NIBIB NIH HHS / United States G0701120 / MRC_ / Medical Research Council / United Kingdom MR/L023784/2 / MRC_ / Medical Research Council / United Kingdom R01 NS062059 / NS / NINDS NIH HHS / United States MR/M013111/1 / MRC_ / Medical Research Council / United Kingdom G1001245 / MRC_ / Medical Research Council / United Kingdom J-0901 / PUK_ / Parkinson's UK / United Kingdom R56 AG058854 / AG / NIA NIH HHS / United States G0700704 / MRC_ / Medical Research Council / United Kingdom / WT_ / Wellcome Trust / United Kingdom MC_PC_17228 / MRC_ / Medical Research Council / United Kingdom BB/F019394/1 / BB_ / Biotechnology and Biological Sciences Research Council / United Kingdom R01 AG022381 / AG / NIA NIH HHS / United States R01 AG050595 / AG / NIA NIH HHS / United States R01 AG059874 / AG / NIA NIH HHS / United States |
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