Title | Association of Uncommon, Noncoding Variants in the APOE Region With Risk of Alzheimer Disease in Adults of European Ancestry. |
Publication Type | Journal Article |
Year of Publication | 2020 |
Authors | Blue EE, Cheng A, Chen S, Yu C-E |
Corporate Authors | Alzheimer’s Disease Genetics Consortium |
Journal | JAMA Netw Open |
Volume | 3 |
Issue | 10 |
Pagination | e2017666 |
Date Published | 2020 10 01 |
ISSN | 2574-3805 |
Keywords | Aged, Aged, 80 and over, Alleles, Alzheimer Disease, Apolipoproteins E, Case-Control Studies, Cohort Studies, Europe, Female, Genetic Variation, Genotype, Humans, Logistic Models, Male, Risk Factors, Whites |
Abstract | Importance: The ε2 and ε4 alleles of the apolipoprotein E (APOE) gene are associated with Alzheimer disease (AD) risk. Although nearby genetic variants have also been shown to be associated with AD, including rs2075650 in the TOMM40 gene and rs4420638 near the APOC1 gene, it is unknown whether these associations are independent of the ε2 and ε4 alleles. |
DOI | 10.1001/jamanetworkopen.2020.17666 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/33090224?dopt=Abstract |
page_expo | External |
Alternate Journal | JAMA Netw Open |
PubMed ID | 33090224 |
PubMed Central ID | PMC7582128 |
Grant List | P30 AG066444 / AG / NIA NIH HHS / United States P30 AG010129 / AG / NIA NIH HHS / United States P50 AG016573 / AG / NIA NIH HHS / United States R01 AG031581 / AG / NIA NIH HHS / United States P30 AG019610 / AG / NIA NIH HHS / United States R01 MH080295 / MH / NIMH NIH HHS / United States P30 AG012300 / AG / NIA NIH HHS / United States P50 AG023501 / AG / NIA NIH HHS / United States / / CIHR / Canada R21 AG024486 / AG / NIA NIH HHS / United States R01 AG027944 / AG / NIA NIH HHS / United States P30 AG010161 / AG / NIA NIH HHS / United States P50 AG016574 / AG / NIA NIH HHS / United States R01 AG059737 / AG / NIA NIH HHS / United States P50 AG008671 / AG / NIA NIH HHS / United States U01 HG004610 / HG / NHGRI NIH HHS / United States / WT_ / Wellcome Trust / United Kingdom R01 AG025259 / AG / NIA NIH HHS / United States P50 AG005133 / AG / NIA NIH HHS / United States R01 AG041797 / AG / NIA NIH HHS / United States P30 AG010124 / AG / NIA NIH HHS / United States P50 AG033514 / AG / NIA NIH HHS / United States P01 AG002219 / AG / NIA NIH HHS / United States P50 AG005146 / AG / NIA NIH HHS / United States U01 AG016976 / AG / NIA NIH HHS / United States R01 AG020688 / AG / NIA NIH HHS / United States U01 AG006781 / AG / NIA NIH HHS / United States R01 AG017173 / AG / NIA NIH HHS / United States P50 AG005136 / AG / NIA NIH HHS / United States P50 AG005681 / AG / NIA NIH HHS / United States P30 AG028377 / AG / NIA NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States I01 BX004823 / BX / BLRD VA / United States U01 AG024904 / AG / NIA NIH HHS / United States U24 AG041689 / AG / NIA NIH HHS / United States R01 AG019085 / AG / NIA NIH HHS / United States P50 AG016570 / AG / NIA NIH HHS / United States U01 AG032984 / AG / NIA NIH HHS / United States UL1 RR029893 / RR / NCRR NIH HHS / United States P01 AG019724 / AG / NIA NIH HHS / United States P30 AG028383 / AG / NIA NIH HHS / United States P50 AG008702 / AG / NIA NIH HHS / United States P50 AG005138 / AG / NIA NIH HHS / United States P50 AG005131 / AG / NIA NIH HHS / United States R37 AG015473 / AG / NIA NIH HHS / United States RC2 AG036528 / AG / NIA NIH HHS / United States P50 AG005142 / AG / NIA NIH HHS / United States R01 NS059873 / NS / NINDS NIH HHS / United States P30 AG008017 / AG / NIA NIH HHS / United States U24 AG026395 / AG / NIA NIH HHS / United States P30 AG013854 / AG / NIA NIH HHS / United States P30 AG013846 / AG / NIA NIH HHS / United States P50 AG016582 / AG / NIA NIH HHS / United States U01 HG006375 / HG / NHGRI NIH HHS / United States R01 CA129769 / CA / NCI NIH HHS / United States R01 AG026916 / AG / NIA NIH HHS / United States |
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