Title | Admixture mapping reveals the association between Native American ancestry at 3q13.11 and reduced risk of Alzheimer's disease in Caribbean Hispanics. |
Publication Type | Journal Article |
Year of Publication | 2021 |
Authors | Horimoto ARVR, Xue D, Thornton TA, Blue EE |
Journal | Alzheimers Res Ther |
Volume | 13 |
Issue | 1 |
Pagination | 122 |
Date Published | 2021 07 03 |
ISSN | 1758-9193 |
Keywords | Alzheimer Disease, American Indians or Alaska Natives, Caribbean Region, Chromosomes, Human, Pair 3, Genetic Predisposition to Disease, Genome-Wide Association Study, Hispanic or Latino, Humans, Polymorphism, Single Nucleotide, Whites |
Abstract | BACKGROUND: Genetic studies have primarily been conducted in European ancestry populations, identifying dozens of loci associated with late-onset Alzheimer's disease (AD). However, much of AD's heritability remains unexplained; as the prevalence of AD varies across populations, the genetic architecture of the disease may also vary by population with the presence of novel variants or loci. |
DOI | 10.1186/s13195-021-00866-9 |
Pubmed Link | https://www.ncbi.nlm.nih.gov/pubmed/34217363?dopt=Abstract |
page_expo | External |
Alternate Journal | Alzheimers Res Ther |
PubMed ID | 34217363 |
PubMed Central ID | PMC8254995 |
Grant List | R01AG059737 / AG / NIA NIH HHS / United States |
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