Description
Data Available
To access this data, please log into DSS and submit an application.
Within the application, add this dataset (accession NG00145) in the “Choose a Dataset” section.
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Description
The Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife) aims are to: conduct a genetically sensitive study of individual differences in behavioral and cognitive change at the cusp of middle adulthood, in participants from the Colorado Adoption Project (CAP) and Longitudinal Twin Study (LTS) studied almost yearly from birth to early adulthood; map individual differences in growth and maintenance of cognitive abilities; evaluate and trace measured physical factors and health behaviors, biochemical markers and measured genetic pathways important to sustaining cognitive performance; and track measured environmental factors that might decrease, sustain or boost cognitive performance. (R01 AG046938 co-PI’s: Reynolds (contact), Wadsworth)
This data release includes data from 1,245 respondents who provided consent to share data and were included in a study of APOE isoforms and IQ data with up to three assessments across childhood and adolescence. [PMCID: PMC6800620]
Sample Summary per Data Type
| Sample Set | Accession | Data Type | Number of Samples |
|---|---|---|---|
| CATSLife APOE | snd10078 | Targeted genotyping | 1,245 |
Available Filesets
| Name | Accession | Latest Release | Description |
|---|---|---|---|
| CATSLife: APOE isoforms, IQ data | fsa000097 | NG00145.v1 | APOE isforms, IQ data |
View the File Manifest for a full list of files released in this dataset.
Subject Information
This data release includes data from 1,245 respondents who provided consent to share data and were included in a study of APOE isoforms and IQ data with up to three assessments across childhood and adolescence [PMCID: PMC6800620].
| Sample Set | Accession Number | Number of Subjects |
|---|---|---|
| CATSLife APOE | snd10078 | 1,245 |
Related Studies
Consent Levels
| Consent Level | Number of Subjects |
|---|---|
| HMB-IRB-PUB-NPU-MDS | 1,245 |
Visit the Data Use Limitations page for definitions of the consent levels above.
Acknowledgement
Acknowledgment statement for any data distributed by NIAGADS:
Data for this study were prepared, archived, and distributed by the National Institute on Aging Alzheimer’s Disease Data Storage Site (NIAGADS) at the University of Pennsylvania (U24-AG041689), funded by the National Institute on Aging.
Use the study-specific acknowledgement statements below (as applicable):
For investigators using any data from this dataset:
Please cite/reference the use of NIAGADS data by including the accession NG00145.
For investigators using The Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife) (sa000046) data:
The Colorado Adoption/Twin Study of Lifespan behavioral development & cognitive aging (CATSLife) project is supported by the National Institute on Aging (grant number NIA R01AG046938) and conducted at the University of Colorado Boulder.
Related Publications
- Reynolds, C. A., Smolen, A., Corley, R. P., Munoz, E., Friedman, N. P., Rhee, S. H., Stallings, M. C., DeFries, J. C., & Wadsworth, S. J. (2019, Dec). APOE effects on cognition from childhood to adolescence. Neurobiol Aging, 84, 239.e231-239.e238. https://doi.org/10.1016/j.neurobiolaging.2019.04.011 PubMed link
- Wadsworth, S. J., Corley, R. P., Munoz, E., Trubenstein, B. P., Knaap, E., DeFries, J. C., Plomin, R., & Reynolds, C. A. (2019, Dec). CATSLife: A Study of Lifespan Behavioral Development and Cognitive Functioning. Twin Res Hum Genet, 22(6), 695-706. https://doi.org/10.1017/thg.2019.49 PubMed link