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#---	GWAS Summary Statistics of informed conditioning analysis in African Americans
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Title:	Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans
	Mez et al. Alzheimer's & Dementia. Volume 13, Issue 2, February 2017, Pages 119-129
	PMID: 27770636 
	PMCID: PMC5318231

The file contains the genome-wide association study (GWAS) summary-level statistics after meta-analyzing GWAS results from 8 parent studies.
The 1825 LOAD cases and 3784 cognitively normal controls for the meta-analysis were assembled by the Alzheimer's Disease Genetic Consortium (ADGC). The detail information for sample recruitment, genotyping, imputation, QC, etc. has been reported previously (Mez et al. Alzheimers Dement. 2017). 
GWAS was performed separately in each study. First, we derived a posterior liability for affection (AD) status conditioned on age, sex, diabetes status, current smoking status, and educational attainment with parameters informed by external prevalence information. To do this, we used the software LTSC (Zaitlen et al. PLoS Genet. 2012). Then, we assessed association between the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for PCs of population structure, APOE and ABCA7. The additive genetic effect of each SNP after imputation was estimated using regression analysis. 
SNP effect estimates and their SEs were combined by a fixed effect model with inverse variance weighted method using the METAL software. After the meta-analysis, the SNPs with available estimates in at least half of the data sets are reported.


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#---	File Name
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META_AA.10_ltscore2_adj.age.sex.db.smk.edu.pcs.apoe.abca7.txt.gz


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#---	Column Information
#---	The columns are separated using tab as a delimiter. 
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Column Number	Column Name	

1	#CHR	Chromosome						
2	BP	Base Position					
3	LocID	chr-baseposition						
4	Allele1	Effect Allele					
5	Allele2	Non-Effect Allele
6	P-value	statistical significance of the effect estimate