SNP rs7256200

CTCCCAAAGTTCTGGGAATACAGGC[T/G]TGAGCCACTGCAACCAGCCAGTAGC

Genomic Context

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Variant Effect Impact (snpEff)

  • High
  • Moderate
  • Low
  • Modifier
  • Not Reported
  • Reference Allele: G
  • Minor Allele/Frequency: T/0.1232
  • Variant Class: single nucleotide variant
  • Closest Gene: APOC1

Genome-wide significance

NIAGADS: Alzheimer's Disease

NIAGADS AD GWAS summary statistics datasets in which SNP rs7256200 has a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

To view functional genomics annotations on the genome browser, first select tracks in the table below and then use the provided button to load the tracks on the browser.

p-Value Allele Track Accession Mapped From Get SNPs
1e-520 G
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
NG00036 N/A
1.05e-63 T
ADGC Age of Onset LOAD
GWAS summary statistics for age of onset in ADGC LOAD GWAS datasets, after adjustment for sex, APOE ε4 number, and population stratification.
NG00048 chr19:45415935
1.20e-46 T
Neuropathologic features of AD and related dementias (case/control)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: general case/control analysis comparing individuals with dementia and AD neuropathologies (cases) to those without clinical dementia and none or minimal AD neuropathologic changes (controls); includes both primary (relaxed documentation) and conservative (strict documentation) datasets
NG00041 N/A

NIAGADS: Related Neuropathologies

NIAGADS non-AD (related neuropathology) GWAS summary statistics datasets in which SNP rs7256200 has a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

To view functional genomics annotations on the genome browser, first select tracks in the table below and then use the provided button to load the tracks on the browser.

p-Value Allele Track Accession Mapped From Get SNPs
4.37e-47 T
Neuritic plaques (presence vs. absence); relaxed
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NPs (presence versus absence), inclusive primary dataset allowing some incomplete documentation of pathological features
NG00041 N/A
2.95e-32 T
Neurofibrillary tangles (ranked by Braak stages)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NFTs (Braak stages)
NG00041 N/A
2.82e-30 T
Neuritic plaques (ranked by CERAD score)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NPs (CERAD score)
NG00041 N/A
1.10e-29 T
Neurofibrillary tangles (ranked by Braak groups)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NFTs (Braak groups)
NG00041 N/A
3.16e-24 T
Neuritic plaques (presence vs. absence); conservative
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NPs (presence versus absence) restricted to cases and controls with complete documentation
NG00041 N/A
7.41e-22 T
Neuritic plaques (presence vs. absence)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: NPs (presence vs. absence)
NG00041 N/A
2.34e-09 T
Lewy body disease (5 category ranking)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: LBD (none, brainstem-predominant, limbic, neocortical, and other regions or not specified)
NG00041 N/A
4.79e-09 T
Lewy body disease (3 category ranking)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: LBD (none, brainstem-predominant, and all other regions or not specified)
NG00041 N/A
1.82e-08 T
Lewy body disease (presence vs. absence)
GWAS summary statistics from a comparative study of neuropathological features of Alzheimer's disease and related dementias: LBD (presence vs. absence)
NG00041 N/A

NHGRI: Alzheimer's Disease

NHGRI: Other Traits

Predicted Effects