SNP rs449647

ACCATGTTGGCCAGGCTGGTCTCAA[T/A]CTCCTGACCTTAAGTGATTCGCCCA

Genomic Context

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Variant Effect Impact (snpEff)

  • High
  • Moderate
  • Low
  • Modifier
  • Not Reported
  • Reference Allele: A
  • Minor Allele/Frequency: T/0.1997
  • Variant Class: single nucleotide variant
  • Closest Gene: APOE

Genome-wide significance

NIAGADS: Alzheimer's Disease

NIAGADS AD GWAS summary statistics datasets in which SNP rs449647 has a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

To view functional genomics annotations on the genome browser, first select tracks in the table below and then use the provided button to load the tracks on the browser.

p-Value Allele Track Accession Mapped From Get SNPs
1.15e-11 A
ADGC Age of Onset LOAD
GWAS summary statistics for age of onset in ADGC LOAD GWAS datasets, after adjustment for sex, APOE ε4 number, and population stratification.
NG00048 chr19:45408564

NIAGADS: Related Neuropathologies

NHGRI: Alzheimer's Disease

NHGRI: Other Traits

Predicted Effects