SNP rs405509

CCCCCAGAATGGAGGAGGGTGTCTG[G/T]ATTACTGGGCGAGGTGTCCTCCCTT

Genomic Context

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Variant Effect Impact (snpEff)

  • High
  • Moderate
  • Low
  • Modifier
  • Not Reported
  • Reference Allele: T
  • Minor Allele/Frequency: G/0.4718
  • Variant Class: single nucleotide variant
  • Closest Gene: APOE

Genome-wide significance

NIAGADS: Alzheimer's Disease

NIAGADS AD GWAS summary statistics datasets in which SNP rs405509 has a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

To view functional genomics annotations on the genome browser, first select tracks in the table below and then use the provided button to load the tracks on the browser.

p-Value Allele Track Accession Mapped From Get SNPs
4.37e-73 T
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
NG00036 N/A
3.02e-44 T
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
NG00027 N/A
6.17e-12 T
ADGC African Americans (2013)
GWAS summary statistics from an ADGC study of African Americans and their genetic risk for LOAD (2013)
NG00039 chr19:45408836

NIAGADS: Related Neuropathologies

NIAGADS non-AD (related neuropathology) GWAS summary statistics datasets in which SNP rs405509 has a genome-wide significance supported by a p-value ≤ 5 x 10-8.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

To view functional genomics annotations on the genome browser, first select tracks in the table below and then use the provided button to load the tracks on the browser.

p-Value Allele Track Accession Mapped From Get SNPs
2.51e-10 C
CSF: Aβ₄₂
GWAS summary statistics for CSF beta-amyloid 42 (AΒ42) levels, after adjustment for age, sex, and population stratification.
NG00049 N/A

NHGRI: Alzheimer's Disease

NHGRI: Other Traits

Predicted Effects