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HLA-DQA1 - ENSG00000196735

major histocompatibility complex, class II, DQ alpha 1

Also known as: CELIAC1

Location: chr6:32,595,956-32,614,839

Gene Type: protein coding

More information
NCBI Gene
3117
HUGO
HGNC:4942
Ensembl
ENSG00000196735
VEGA
OTTHUMG00000031106
OMIM
146880
UniProtKB
P01909

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

To add tracks, use the provided link to switch to the full genome browser view.

Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

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Accession Population N SNPs p-value Sign. Level rho CMAF CMAC Covariates Variant Filter Caveats
NG00065 European 1 0.359 N/A 0 4.8e-05 1.0 PCs and sequencing center VEP HIGH
NG00065 European 1 0.359 N/A 0 4.8e-05 1.0 PCs and sequencing center LOF
NG00065 European 11 0.507 N/A 1 0.095 1987.1 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 11 0.594 N/A 1 0.095 1987.1 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 European 1 0.598 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 European 1 0.598 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 Meta 11 0.658 N/A 1 0.095 2061.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 1 0.731 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 European 1 0.731 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 Meta 11 0.747 N/A 1 0.095 2061.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 5 0.874 N/A 1 0.094 74.6 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 5 0.889 N/A 1 0.094 74.6 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 11 0.894 N/A 1 0.095 1987.1 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 5 0.934 N/A 1 0.094 74.6 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Meta 11 0.966 N/A 1 0.095 2061.8 PCs and sequencing center VEP MOD-HIGH N/A

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the HLA-DQA1 gene.

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The HLA-DQA1 gene contains 3,478 variants records (corresponding to 3,000 unique genomic positions).

The following variants, contained within ±100kb of HLA-DQA1, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of HLA-DQA1 that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

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Login in to select variants and add them to your basket.

Relative Position Variant ADSP? Allele p-Value Track Accession
upstream C 2.9e-12 IGAP 2013: Stages 1 and 2 NG00036
upstream A 5.1e-12 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 1.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 2.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 2.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 2.7e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.8e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.8e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 2.9e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 3.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 3.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.7e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 3.7e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 4.0e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.0e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.1e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 4.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 4.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 4.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 4.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 4.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 4.4e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 4.9e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 5.0e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 5.1e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 5.2e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 5.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.6e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.6e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 5.9e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 6.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 6.7e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 6.8e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 7.0e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 7.1e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 7.6e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 8.0e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 8.1e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 8.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 8.5e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream G 8.6e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 8.9e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 9.3e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream C 9.7e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream A 9.8e-11 IGAP 2013: Stages 1 and 2 NG00036
upstream T 1.1e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream A 1.1e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 1.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 1.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 1.3e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.3e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 1.4e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 1.5e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 1.5e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 1.7e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream T 1.7e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 1.9e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.0e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 2.1e-10 IGAP 2013: Stages 1 and 2 NG00036
downstream C 2.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 2.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.4e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 2.4e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.5e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 2.5e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream T 2.6e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 2.7e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 3.3e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 3.3e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 3.7e-10 IGAP 2013: Stages 1 and 2 NG00036
downstream T 4.4e-10 IGAP 2013: Stages 1 and 2 NG00036
downstream T 4.4e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 4.8e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 5.6e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 5.8e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.9e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream G 6.0e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 6.5e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream A 6.8e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 6.9e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 7.1e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 8.0e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 8.6e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 9.2e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 9.8e-10 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.1e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream T 1.1e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream T 1.2e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream A 1.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 1.3e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 1.4e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream C 1.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 1.5e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 1.6e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 1.6e-9 IGAP 2013: Stages 1 and 2 NG00036
in gene N/A G 1.7e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream C 1.9e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 2.0e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 2.3e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream T 2.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 2.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 2.7e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 3.0e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 3.0e-9 IGAP 2013: Stages 1 and 2 NG00036
in gene N/A T 3.1e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 3.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 3.2e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream G 3.3e-9 IGAP 2013: Stages 1 and 2 NG00036
in gene N/A A 3.4e-9 IGAP 2013: Stage 1 NG00036
upstream N/A T 3.8e-9 IGAP 2013: Stage 1 NG00036
upstream C 3.9e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 3.9e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 3.9e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream C 4.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 4.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 4.5e-9 IGAP 2013: Stages 1 and 2 NG00036
in gene N/A T 4.7e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 5.2e-9 IGAP 2013: Stage 1 NG00036
upstream A 5.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 5.3e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 5.4e-9 IGAP 2013: Stage 1 NG00036
upstream A 5.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 5.6e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream C 5.9e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream T 6.0e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 6.1e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 6.3e-9 IGAP 2013: Stage 1 NG00036
upstream N/A A 6.3e-9 IGAP 2013: Stage 1 NG00036
upstream N/A A 6.6e-9 IGAP 2013: Stage 1 NG00036
downstream G 6.7e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 6.7e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream G 6.8e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 6.8e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 6.8e-9 IGAP 2013: Stage 1 NG00036
upstream N/A A 7.1e-9 IGAP 2013: Stage 1 NG00036
upstream G 7.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 7.3e-9 IGAP 2013: Stage 1 NG00036
upstream N/A G 7.3e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 7.4e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 7.8e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 7.9e-9 IGAP 2013: Stage 1 NG00036
upstream A 7.9e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream T 8.0e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream T 8.0e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 8.1e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 8.4e-9 IGAP 2013: Stage 1 NG00036
downstream C 8.5e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 8.7e-9 IGAP 2013: Stage 1 NG00036
downstream C 8.8e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 9.2e-9 IGAP 2013: Stage 1 NG00036
upstream A 9.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream A 9.5e-9 IGAP 2013: Stage 1 NG00036
upstream A 9.6e-9 IGAP 2013: Stage 1 NG00036
upstream A 9.6e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream G 9.6e-9 IGAP 2013: Stage 1 NG00036
downstream T 9.7e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream C 9.8e-9 IGAP 2013: Stage 1 NG00036
upstream N/A G 9.9e-9 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.0e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.0e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.0e-8 IGAP 2013: Stage 1 NG00036
downstream N/A 1.1e-8 ADSP Single-Variant Risk Association: European (Model 1) NG00065
downstream N/A 1.1e-8 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 1) NG00065
downstream N/A 1.1e-8 ADSP Single-Variant Risk Association: meta analysis (Model 1) NG00065
upstream A 1.1e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.1e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.1e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.1e-8 IGAP 2013: Stage 1 NG00036
downstream T 1.1e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream G 1.1e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 1.1e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.2e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.2e-8 IGAP 2013: Stage 1 NG00036
downstream A 1.2e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream G 1.3e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 1.3e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.3e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.4e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.4e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.5e-8 IGAP 2013: Stage 1 NG00036
downstream C 1.5e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.5e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 1.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream G 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-8 IGAP 2013: Stage 1 NG00036
downstream C 1.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.8e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.8e-8 IGAP 2013: Stage 1 NG00036
downstream T 1.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream A 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream T 1.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream C 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 1.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream T 1.9e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream T 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.0e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.0e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 2.0e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream T 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream G 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream G 2.1e-8 IGAP 2013: Stage 1 NG00036
upstream T 2.1e-8 IGAP 2013: Stage 1 NG00036
downstream A 2.2e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 2.2e-8 IGAP 2013: Stage 1 NG00036
upstream G 2.2e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 2.2e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.2e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.3e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.3e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream A 2.3e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 2.3e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.3e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.3e-8 IGAP 2013: Stage 1 NG00036
upstream T 2.4e-8 IGAP 2013: Stage 1 NG00036
upstream G 2.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 2.5e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.5e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.6e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 2.6e-8 IGAP 2013: Stage 1 NG00036
upstream C 2.6e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 2.6e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 2.6e-8 IGAP 2013: Stage 1 NG00036
upstream G 2.6e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 2.7e-8 IGAP 2013: Stage 1 NG00036
downstream A 2.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 2.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.7e-8 IGAP 2013: Stage 1 NG00036
downstream T 2.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream A 2.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream T 2.7e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 2.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A C 2.8e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 2.8e-8 IGAP 2013: Stage 1 NG00036
downstream C 2.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 2.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 2.9e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 2.9e-8 IGAP 2013: Stage 1 NG00036
upstream A 2.9e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.0e-8 IGAP 2013: Stage 1 NG00036
upstream A 3.0e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 3.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 3.2e-8 IGAP 2013: Stage 1 NG00036
downstream A 3.2e-8 IGAP 2013: Stages 1 and 2 NG00036
in gene N/A G 3.3e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A A 3.4e-8 IGAP 2013: Stage 1 NG00036
upstream T 3.4e-8 IGAP 2013: Stage 1 NG00036
upstream T 3.5e-8 IGAP 2013: Stage 1 NG00036
upstream T 3.5e-8 IGAP 2013: Stage 1 NG00036
upstream G 3.5e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 3.5e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 3.5e-8 IGAP 2013: Stage 1 NG00036
upstream T 3.5e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream A 3.6e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A C 3.6e-8 IGAP 2013: Stage 1 NG00036
upstream A 3.6e-8 IGAP 2013: Stage 1 NG00036
upstream G 3.6e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream C 3.6e-8 IGAP 2013: Stage 1 NG00036
upstream G 3.6e-8 IGAP 2013: Stage 1 NG00036
upstream A 3.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 3.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 3.7e-8 IGAP 2013: Stage 1 NG00036
downstream A 3.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream T 3.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 3.7e-8 IGAP 2013: Stage 1 NG00036
upstream N/A T 3.8e-8 IGAP 2013: Stage 1 NG00036
downstream T 4.0e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 4.1e-8 IGAP 2013: Stage 1 NG00036
downstream C 4.1e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.1e-8 IGAP 2013: Stages 1 and 2 NG00036
in gene T 4.1e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream C 4.1e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.2e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 4.2e-8 IGAP 2013: Stage 1 NG00036
upstream A 4.3e-8 IGAP 2013: Stage 1 NG00036
upstream G 4.3e-8 IGAP 2013: Stage 1 NG00036
upstream G 4.3e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A G 4.4e-8 IGAP 2013: Stage 1 NG00036
upstream N/A A 4.5e-8 IGAP 2013: Stage 1 NG00036
upstream A 4.5e-8 IGAP 2013: Stage 1 NG00036
downstream G 4.7e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A G 4.8e-8 IGAP 2013: Stage 1 NG00036
upstream A 4.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream G 4.8e-8 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A T 4.8e-8 IGAP 2013: Stage 1 NG00036
upstream T 4.9e-8 IGAP 2013: Stages 1 and 2 NG00036

NHGRI GWAS: Alzheimer's Disease

Variants contained within ±100kb of HLA-DQA1 that are associated with Alzheimer's disease in the NHGRI GWAS Catalog.

The following variants, contained within ±100kb of HLA-DQA1, have been associated with AD-relevant neuropathologies in a GWAS study:

NIAGADS GWAS: AD biomarkers and related neuropathologies

Variants contained within ±100kb of HLA-DQA1 that have genome-wide significance in a NIAGADS GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

NHGRI GWAS: Other Traits (incl. related neuropathologies and AD biomarkers)

Variants contained within ±100kb of HLA-DQA1 that are associated with a trait in the NHGRI GWAS Catalog.