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OGT - ENSG00000147162

O-linked N-acetylglucosamine (GlcNAc) transferase

Also known as: O-GLCNAC, HRNT1, MGC22921, FLJ23071

Location: chrX:70,752,933-70,795,747

Gene Type: protein coding

More information
NCBI Gene
8473
HUGO
HGNC:8127
Ensembl
ENSG00000147162
VEGA
OTTHUMG00000033316
OMIM
300255
UniProtKB
O15294

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

To add tracks, use the provided link to switch to the full genome browser view.

Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the OGT gene.

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The OGT gene contains 1,537 variants records (corresponding to 1,488 unique genomic positions).

The following variants, contained within ±100kb of OGT, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of OGT that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

NHGRI GWAS: Alzheimer's Disease

Variants contained within ±100kb of OGT that are associated with Alzheimer's disease in the NHGRI GWAS Catalog.

The following variants, contained within ±100kb of OGT, have been associated with AD-relevant neuropathologies in a GWAS study:

NIAGADS GWAS: AD biomarkers and related neuropathologies

Variants contained within ±100kb of OGT that have genome-wide significance in a NIAGADS GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

NHGRI GWAS: Other Traits (incl. related neuropathologies and AD biomarkers)

Variants contained within ±100kb of OGT that are associated with a trait in the NHGRI GWAS Catalog.

Functional Genomics

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Explore all functional genomics annotations within the region of the OGT gene (chrX:70752933-70795747)

Transcription Factor Binding Site Overlap in Gene Promoter Region (ENCODE ChIP-SEQ)

ChIP-Seq sites for transcription factor binding (from selected brain-relevant ENCODE tracks) within the promoter region of this gene. See methods for more information.

Functional Annotation

Gene Ontology

Functional annotations were obtained from UniProt-GOA gene association files.

Click on a term accession number to view term details at the Gene Ontology Consortium.

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Ontology GO Accession Term Evidence Code
BP GO:0006915 apoptotic process IEA,IDA
BP GO:0016569 chromatin modification IEA
BP GO:0032922 circadian regulation of gene expression ISS,IEA
BP GO:0080182 histone H3-K4 trimethylation IMP
BP GO:0043984 histone H4-K16 acetylation IDA
BP GO:0043981 histone H4-K5 acetylation IDA
BP GO:0043982 histone H4-K8 acetylation IDA
BP GO:0031397 negative regulation of protein ubiquitination IEA,ISS
BP GO:0048015 phosphatidylinositol-mediated signaling IDA
BP GO:0061087 positive regulation of histone H3-K27 methylation IMP
BP GO:0045862 positive regulation of proteolysis IDA
BP GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP,IDA
BP GO:0016579 protein deubiquitination TAS
BP GO:0006486 protein glycosylation IEA
BP GO:0006493 protein O-linked glycosylation TAS,IDA,IEA,IMP
BP GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis ISS,IEA
BP GO:0006110 regulation of glycolytic process IDA
BP GO:0046626 regulation of insulin receptor signaling pathway IDA
BP GO:0035020 regulation of Rac protein signal transduction IDA
BP GO:0032868 response to insulin IDA
BP GO:0007584 response to nutrient TAS
BP GO:0048511 rhythmic process IEA
BP GO:0007165 signal transduction TAS
CC GO:0005737 cytoplasm IEA
CC GO:0005829 cytosol TAS,IDA
CC GO:0000123 histone acetyltransferase complex IDA
CC GO:0016020 membrane IEA
CC GO:0005739 mitochondrion IEA
CC GO:0005654 nucleoplasm IDA,TAS
CC GO:0005634 nucleus IDA,TAS,IEA
CC GO:0005886 plasma membrane IDA,IEA
MF GO:0008375 acetylglucosaminyltransferase activity TAS
MF GO:0046972 histone acetyltransferase activity (H4-K16 specific) IDA
MF GO:0043995 histone acetyltransferase activity (H4-K5 specific) IDA
MF GO:0043996 histone acetyltransferase activity (H4-K8 specific) IDA
MF GO:0008289 lipid binding IEA
MF GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
MF GO:0005515 protein binding IPI
MF GO:0016262 protein N-acetylglucosaminyltransferase activity IDA
MF GO:0097363 protein O-GlcNAc transferase activity IEA,ISS,IMP
MF GO:0016740 transferase activity IEA
MF GO:0016757 transferase activity, transferring glycosyl groups IEA

KEGG Pathways

Click on a pathway accession number to view term details at KEGG.

Click on the number in the Find Similar column to get a list of genes annotated by the associated pathway.

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Pathway KEGG Accession Graph
Insulin resistance hsa04931
Other types of O-glycan biosynthesis hsa00514