Genomic Context

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Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

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Accession Population N SNPs p-value Sign. Level rho CMAF CMAC Covariates Variant Filter Caveats
NG00065 European 54 0.132 N/A 1 4.6e-03 96.4 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 European 54 0.159 N/A 0 4.6e-03 96.4 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 European 54 0.263 N/A 0 4.6e-03 96.4 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 5 0.283 N/A 0 2.4e-04 5.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 European 5 0.283 N/A 0 2.4e-04 5.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 Meta 59 0.320 N/A 1 5.3e-03 115.8 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 European 5 0.350 N/A 1 2.4e-04 5.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 European 5 0.350 N/A 1 2.4e-04 5.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 European 5 0.421 N/A 0 2.4e-04 5.0 PCs and sequencing center LOF
NG00065 European 5 0.421 N/A 0 2.4e-04 5.0 PCs and sequencing center VEP HIGH
NG00065 Meta 59 0.426 N/A 0 5.3e-03 115.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Meta 59 0.537 N/A 0 5.3e-03 115.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 6 0.913 N/A 0 0.024 19.0 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 6 0.926 N/A 1 0.024 19.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 6 0.940 N/A 0 0.024 19.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the WDR18 gene.

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The WDR18 gene contains 1,289 variants records (corresponding to 1,186 unique genomic positions).

The following variants, contained within ±100kb of WDR18, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of WDR18 that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

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Login in to select variants and add them to your basket.

Relative Position Variant ADSP? Allele p-Value Track Accession
downstream N/A 6.0e-25 ADSP Single-Variant Risk Association: European (Model 1) NG00065
downstream N/A 6.0e-25 ADSP Single-Variant Risk Association: meta analysis (Model 1) NG00065
downstream N/A 6.0e-25 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 1) NG00065
downstream N/A 8.2e-20 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 1) NG00065
downstream N/A 8.2e-20 ADSP Single-Variant Risk Association: European (Model 1) NG00065
downstream N/A 8.2e-20 ADSP Single-Variant Risk Association: meta analysis (Model 1) NG00065
downstream N/A 4.4e-17 ADSP Single-Variant Risk Association: meta analysis (Model 2) NG00065
downstream N/A 4.4e-17 ADSP Single-Variant Risk Association: European (Model 2) NG00065
downstream N/A 4.4e-17 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 2) NG00065
downstream A 1.1e-15 IGAP 2013: Stages 1 and 2 NG00036
downstream G 1.4e-15 IGAP 2013: Stages 1 and 2 NG00036
downstream G 4.2e-13 IGAP 2013: Stages 1 and 2 NG00036
downstream G 5.2e-13 IGAP 2013: Stages 1 and 2 NG00036
downstream N/A 6.0e-13 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 2) NG00065
downstream N/A 6.0e-13 ADSP Single-Variant Risk Association: meta analysis (Model 2) NG00065
downstream N/A 6.0e-13 ADSP Single-Variant Risk Association: European (Model 2) NG00065
downstream G 1.9e-12 IGAP 2013: Stages 1 and 2 NG00036
downstream A 5.5e-12 IGAP 2013: Stages 1 and 2 NG00036
downstream T 4.9e-11 IGAP 2013: Stages 1 and 2 NG00036
downstream A 4.5e-10 IGAP 2013: Stages 1 and 2 NG00036
downstream T 7.8e-10 IGAP 2013: Stages 1 and 2 NG00036
downstream C 1.3e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream G 1.5e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream A 1.7e-9 IGAP 2013: Stage 1 NG00036
downstream C 1.7e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream A 1.9e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream A 2.2e-9 ADGC African Americans 2013: APOE Adj NG00039
downstream A 2.3e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream T 2.9e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream G 4.3e-9 IGAP 2013: Stage 1 NG00036
downstream A 4.7e-9 IGAP 2013: Stages 1 and 2 NG00036
downstream A 4.7e-9 IGAP 2013: Stage 1 NG00036
downstream C 9.2e-9 IGAP 2013: Stages 1 and 2 NG00036
upstream N/A 1.1e-8 ADSP Single-Variant Risk Association: meta analysis (Model 1) NG00065
upstream N/A 1.1e-8 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 1) NG00065
upstream N/A 1.1e-8 ADSP Single-Variant Risk Association: European (Model 1) NG00065
downstream G 1.2e-8 IGAP 2013: Stage 1 NG00036
downstream G 1.3e-8 IGAP 2013: Stage 1 NG00036
downstream G 1.3e-8 IGAP 2013: Stage 1 NG00036
downstream G 1.5e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream T 1.7e-8 IGAP 2013: Stage 1 NG00036
downstream A 1.8e-8 IGAP 2013: Stage 1 NG00036
downstream G 2.0e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream N/A 2.0e-8 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 1) NG00065
downstream N/A 2.0e-8 ADSP Single-Variant Risk Association: European (Model 1) NG00065
downstream N/A 2.0e-8 ADSP Single-Variant Risk Association: meta analysis (Model 1) NG00065
downstream A 3.1e-8 IGAP 2013: Stages 1 and 2 NG00036
downstream T 3.1e-8 ADGC African Americans 2013: APOE Adj NG00039

NHGRI GWAS: Alzheimer's Disease

Variants contained within ±100kb of WDR18 that are associated with Alzheimer's disease in the NHGRI GWAS Catalog.

The following variants, contained within ±100kb of WDR18, have been associated with AD-relevant neuropathologies in a GWAS study:

NIAGADS GWAS: AD biomarkers and related neuropathologies

Variants contained within ±100kb of WDR18 that have genome-wide significance in a NIAGADS GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

NHGRI GWAS: Other Traits (incl. related neuropathologies and AD biomarkers)

Variants contained within ±100kb of WDR18 that are associated with a trait in the NHGRI GWAS Catalog.

Functional Genomics

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Explore all functional genomics annotations within the region of the WDR18 gene (chr19:983174-994569)

Transcription Factor Binding Site Overlap in Gene Promoter Region (ENCODE ChIP-SEQ)

ChIP-Seq sites for transcription factor binding (from selected brain-relevant ENCODE tracks) within the promoter region of this gene. See methods for more information.

Functional Annotation

Gene Ontology

Functional annotations were obtained from UniProt-GOA gene association files.

Click on a term accession number to view term details at the Gene Ontology Consortium.

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Ontology GO Accession Term Evidence Code
BP GO:0007275 multicellular organism development IEA
BP GO:0006364 rRNA processing TAS
CC GO:0005737 cytoplasm IEA
CC GO:0005654 nucleoplasm IEA,TAS
CC GO:0005634 nucleus IEA
MF GO:0005515 protein binding IPI

KEGG Pathways

Click on a pathway accession number to view term details at KEGG.

Click on the number in the Find Similar column to get a list of genes annotated by the associated pathway.