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TOMM40 - ENSG00000130204

translocase of outer mitochondrial membrane 40

Also known as: PEREC1, D19S1177E, C19orf1, TOM40, PER-EC1

Location: chr19:45,393,826-45,406,946

Gene Type: protein coding

More information
NCBI Gene
10452
HUGO
HGNC:18001
Ensembl
ENSG00000130204
VEGA
OTTHUMG00000180842
OMIM
608061
UniProtKB
O96008

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

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Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

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Accession Population N SNPs p-value Sign. Level rho CMAF CMAC Covariates Variant Filter Caveats
NG00065 Meta 19 5.6e-03 N/A 0 2.0e-03 44.0 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 European 18 6.0e-03 N/A 0 2.0e-03 42.0 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Meta 19 0.234 N/A 0 2.0e-03 44.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 18 0.263 N/A 1 2.0e-03 42.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 2 0.295 N/A 1 2.5e-03 2.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH
NG00065 Caribbean Hispanic 2 0.304 N/A 1 2.5e-03 2.0 PCs and sequencing center VEP MOD-HIGH
NG00065 Caribbean Hispanic 2 0.351 N/A 0 2.5e-03 2.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH
NG00065 European 1 0.355 N/A 0 4.8e-05 1.0 PCs and sequencing center VEP HIGH
NG00065 European 1 0.355 N/A 0 4.8e-05 1.0 PCs and sequencing center LOF
NG00065 European 1 0.426 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 European 1 0.426 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 European 1 0.431 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 European 1 0.431 N/A 0 4.8e-05 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 European 18 0.611 N/A 1 2.0e-03 42.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Meta 19 0.625 N/A 0 2.0e-03 44.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the TOMM40 gene.

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The TOMM40 gene contains 1,104 variants records (corresponding to 1,051 unique genomic positions).

The following variants, contained within ±100kb of TOMM40, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of TOMM40 that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

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Login in to select variants and add them to your basket.

Relative Position Variant ADSP? Allele p-Value Track Accession
downstream A 0.000 ADGC 2011: Stages 1 and 2 NG00027
upstream T 2.5e-575 IGAP 2013: Stage 1 NG00036
downstream T 1.4e-546 Transethnic LOAD: All Samples NG00056
downstream C 6.7e-536 IGAP 2013: Stage 1 NG00036
downstream A 9.9e-523 IGAP 2013: Stage 1 NG00036
downstream A 1.2e-522 IGAP 2013: Stage 1 NG00036
downstream T 1.8e-520 IGAP 2013: Stage 1 NG00036
in gene T 2.0e-486 IGAP 2013: Stage 1 NG00036
downstream G 7.8e-482 IGAP 2013: Stage 1 NG00036
in gene G 8.5e-475 IGAP 2013: Stage 1 NG00036
in gene C 8.9e-469 IGAP 2013: Stage 1 NG00036
in gene G 6.4e-466 IGAP 2013: Stage 1 NG00036
in gene T 2.6e-464 IGAP 2013: Stage 1 NG00036
in gene G 5.1e-464 IGAP 2013: Stage 1 NG00036
in gene C 2.5e-462 IGAP 2013: Stage 1 NG00036
downstream A 2.0e-454 IGAP 2013: Stage 1 NG00036
upstream G 6.5e-442 IGAP 2013: Stage 1 NG00036
upstream A 4.9e-440 IGAP 2013: Stage 1 NG00036
downstream C 3.8e-439 Transethnic LOAD: All Samples NG00056
downstream A 5.3e-435 Transethnic LOAD: All Samples NG00056
upstream G 2.7e-434 IGAP 2013: Stage 1 NG00036
upstream G 3.2e-434 IGAP 2013: Stage 1 NG00036
in gene T 9.7e-434 IGAP 2013: Stage 1 NG00036
upstream A 5.4e-432 IGAP 2013: Stage 1 NG00036
downstream A 2.5e-427 IGAP 2013: Stage 1 NG00036
downstream A 1.1e-421 IGAP 2013: Stage 1 NG00036
upstream T 4.4e-419 Transethnic LOAD: All Samples NG00056
downstream A 6.3e-411 Transethnic LOAD: All Samples NG00056
downstream A 2.2e-410 Transethnic LOAD: All Samples NG00056
downstream A 7.0e-405 IGAP 2013: Stage 1 NG00036
downstream G 1.7e-396 IGAP 2013: Stage 1 NG00036
downstream C 8.6e-390 IGAP 2013: Stage 1 NG00036
downstream A 1.0e-385 Transethnic LOAD: All Samples NG00056
downstream T 2.1e-373 IGAP 2013: Stage 1 NG00036
downstream A 3.5e-359 Transethnic LOAD: All Samples NG00056
downstream T 6.6e-357 IGAP (2013): ADGC Subset NG00053
upstream T 7.5e-357 IGAP (2013): ADGC Subset NG00053
in gene A 3.2e-354 IGAP 2013: Stage 1 NG00036
downstream T 6.3e-353 Transethnic LOAD: All Samples NG00056
downstream A 3.5e-352 Transethnic LOAD: All Samples NG00056
downstream A 6.1e-352 Transethnic LOAD: All Samples NG00056
upstream C 9.0e-350 Transethnic LOAD: All Samples NG00056
upstream A 1.2e-349 Transethnic LOAD: All Samples NG00056
upstream A 7.7e-349 Transethnic LOAD: All Samples NG00056
in gene T 4.4e-344 Transethnic LOAD: All Samples NG00056
in gene A 1.2e-342 IGAP 2013: Stage 1 NG00036
upstream A 1.2e-339 Transethnic LOAD: All Samples NG00056
in gene C 2.6e-336 Transethnic LOAD: All Samples NG00056
in gene T 2.5e-335 Transethnic LOAD: All Samples NG00056
upstream N/A T 3.0e-333 Transethnic LOAD: All Samples NG00056
downstream C 7.6e-333 IGAP (2013): ADGC Subset NG00053
in gene T 1.4e-332 Transethnic LOAD: All Samples NG00056
in gene T 9.6e-331 Transethnic LOAD: All Samples NG00056
in gene T 1.6e-327 Transethnic LOAD: All Samples NG00056
downstream T 2.8e-326 IGAP 2013: Stage 1 NG00036
downstream A 4.3e-326 IGAP (2013): ADGC Subset NG00053
in gene A 3.1e-317 Transethnic LOAD: All Samples NG00056
downstream A 1.4e-313 IGAP (2013): ADGC Subset NG00053
downstream A 3.4e-311 IGAP (2013): ADGC Subset NG00053
downstream T 1.2e-310 IGAP (2013): ADGC Subset NG00053
downstream A 2.2e-309 Transethnic LOAD: All Samples NG00056
downstream T 1.5e-307 Transethnic LOAD: All Samples NG00056
in gene T 2.8e-300 IGAP (2013): ADGC Subset NG00053
upstream A 7.1e-300 Transethnic LOAD: All Samples NG00056
in gene T 1.2e-298 Transethnic LOAD: All Samples NG00056
in gene A 8.8e-297 Transethnic LOAD: All Samples NG00056
in gene T 1.8e-294 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-291 Transethnic LOAD: All Samples NG00056
downstream A 8.0e-291 IGAP (2013): ADGC Subset NG00053
downstream A 1.8e-290 IGAP (2013): ADGC Subset NG00053
in gene T 6.4e-290 IGAP (2013): ADGC Subset NG00053
in gene C 4.5e-288 IGAP (2013): ADGC Subset NG00053
in gene T 1.7e-286 IGAP (2013): ADGC Subset NG00053
downstream A 4.9e-286 IGAP (2013): ADGC Subset NG00053
in gene A 1.5e-285 IGAP (2013): ADGC Subset NG00053
in gene T 3.3e-285 IGAP (2013): ADGC Subset NG00053
upstream A 2.0e-273 IGAP (2013): ADGC Subset NG00053
upstream A 1.6e-270 IGAP (2013): ADGC Subset NG00053
upstream A 2.9e-268 IGAP (2013): ADGC Subset NG00053
downstream A 1.1e-266 ADGC 2011: Stage 1 NG00027
upstream C 1.3e-263 IGAP (2013): ADGC Subset NG00053
upstream A 3.0e-263 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-260 Transethnic LOAD: All Samples NG00056
in gene T 3.0e-254 IGAP (2013): ADGC Subset NG00053
downstream A 5.7e-243 IGAP (2013): ADGC Subset NG00053
downstream T 2.8e-239 IGAP (2013): ADGC Subset NG00053
downstream T 2.1e-232 IGAP (2013): ADGC Subset NG00053
in gene A 3.1e-226 IGAP (2013): ADGC Subset NG00053
downstream N/A A 3.5e-224 Transethnic LOAD: All Samples NG00056
in gene A 8.2e-216 Transethnic LOAD: All Samples NG00056
in gene A 6.4e-212 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-210 Transethnic LOAD: All Samples NG00056
upstream T 2.2e-206 ADGC 2011: Stage 1 NG00027
downstream T 1.4e-204 IGAP (2013): ADGC Subset NG00053
in gene A 6.2e-184 ADGC 2011: Stage 1 NG00027
in gene T 8.2e-178 ADGC 2011: Stage 1 NG00027
upstream G 2.2e-167 IGAP 2013: Stage 1 NG00036
downstream A 1.7e-134 IGAP 2013: Stage 1 NG00036
in gene A 6.0e-134 AD Age of Onset Survival (IGAP) NG00058
in gene T 1.4e-133 AD Age of Onset Survival (IGAP) NG00058
in gene A 1.9e-133 Transethnic LOAD: All Samples NG00056
in gene C 3.0e-133 AD Age of Onset Survival (IGAP) NG00058
in gene T 4.9e-133 AD Age of Onset Survival (IGAP) NG00058
in gene A 2.2e-132 Transethnic LOAD: All Samples NG00056
in gene T 4.7e-132 Transethnic LOAD: All Samples NG00056
in gene T 9.5e-132 Transethnic LOAD: All Samples NG00056
downstream T 4.3e-131 AD Age of Onset Survival (IGAP) NG00058
in gene A 1.1e-128 ADGC 2011: Stage 1 NG00027
in gene G 1.7e-128 IGAP 2013: Stage 1 NG00036
in gene T 3.6e-128 Transethnic LOAD: All Samples NG00056
in gene C 2.3e-127 IGAP 2013: Stage 1 NG00036
in gene C 1.0e-126 IGAP 2013: Stage 1 NG00036
in gene G 1.7e-126 IGAP 2013: Stage 1 NG00036
downstream A 3.0e-125 Transethnic LOAD: All Samples NG00056
downstream A 3.3e-125 IGAP 2013: Stage 1 NG00036
in gene T 6.2e-125 IGAP 2013: Stage 1 NG00036
in gene N/A 2.8e-122 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0) NG00065
in gene N/A 2.8e-122 ADSP Single-Variant Risk Association: European (Model 0) NG00065
downstream A 3.8e-121 ADGC 2011: Stage 2 NG00027
in gene N/A 2.0e-117 ADSP Single-Variant Risk Association: meta analysis (Model 0) NG00065
downstream A 8.1e-116 IGAP (2013): ADGC Subset NG00053
in gene T 3.5e-115 IGAP 2013: Stage 1 NG00036
in gene G 2.0e-114 IGAP 2013: Stage 1 NG00036
in gene T 4.8e-114 IGAP 2013: Stage 1 NG00036
in gene C 3.2e-112 IGAP 2013: Stage 1 NG00036
downstream A 9.0e-109 IGAP 2013: Stage 1 NG00036
upstream A 1.5e-108 IGAP 2013: Stage 1 NG00036
downstream A 6.8e-106 AD Age of Onset Survival (IGAP) NG00058
downstream A 5.1e-104 IGAP 2013: Stage 1 NG00036
upstream C 1.9e-103 IGAP (2013): ADGC Subset NG00053
downstream A 3.0e-102 AD Age of Onset Survival (IGAP) NG00058
in gene G 1.2e-101 IGAP 2013: Stage 1 NG00036
downstream A 1.4e-101 Transethnic LOAD: All Samples NG00056
downstream T 1.4e-101 AD Age of Onset Survival (IGAP) NG00058
downstream A 2.2e-101 AD Age of Onset Survival (IGAP) NG00058
downstream A 2.3e-101 AD Age of Onset Survival (IGAP) NG00058
downstream A 3.8e-101 IGAP 2013: Stage 1 NG00036
downstream C 1.3e-100 AD Age of Onset Survival (IGAP) NG00058
downstream A 4.8e-100 Transethnic LOAD: All Samples NG00056
downstream T 2.3e-99 Transethnic LOAD: All Samples NG00056
in gene C 8.3e-99 Transethnic LOAD: All Samples NG00056
upstream A 2.0e-98 IGAP (2013): ADGC Subset NG00053
in gene T 9.1e-98 Transethnic LOAD: All Samples NG00056
in gene G 5.4e-97 IGAP 2013: Stage 1 NG00036
in gene A 8.5e-97 Transethnic LOAD: All Samples NG00056
upstream T 3.3e-96 ADGC Age of Onset LOAD NG00048
upstream A 3.3e-96 IGAP 2013: Stage 1 NG00036
upstream T 3.7e-96 AD Age of Onset Survival (IGAP) NG00058
in gene A 2.0e-95 Transethnic LOAD: All Samples NG00056
downstream A 3.8e-95 AD Age of Onset Survival (IGAP) NG00058
in gene T 1.2e-94 Transethnic LOAD: All Samples NG00056
in gene T 1.1e-93 ADGC Age of Onset LOAD NG00048
in gene T 3.5e-93 ADGC Age of Onset LOAD NG00048
downstream A 1.3e-92 Transethnic LOAD: All Samples NG00056
downstream T 6.9e-89 IGAP 2013: Stage 1 NG00036
downstream T 8.1e-89 ADGC Age of Onset LOAD NG00048
upstream C 9.9e-89 IGAP 2013: Stage 1 NG00036
downstream T 1.3e-88 IGAP 2013: Stage 1 NG00036
upstream C 4.2e-87 IGAP 2013: Stage 1 NG00036
in gene A 5.4e-87 IGAP (2013): ADGC Subset NG00053
upstream G 1.4e-86 IGAP 2013: Stage 1 NG00036
downstream T 3.0e-86 Transethnic LOAD: All Samples NG00056
upstream T 1.8e-85 IGAP 2013: Stage 1 NG00036
upstream C 2.8e-85 IGAP 2013: Stage 1 NG00036
downstream A 2.9e-85 Transethnic LOAD: All Samples NG00056
upstream A 2.9e-85 IGAP 2013: Stage 1 NG00036
downstream A 3.9e-85 IGAP 2013: Stage 1 NG00036
downstream T 9.0e-85 Transethnic LOAD: All Samples NG00056
upstream N/A T 1.1e-84 AD Age of Onset Survival (IGAP) NG00058
in gene N/A 1.7e-84 ADSP Single-Variant Risk Association: European (Model 0) NG00065
in gene N/A 1.7e-84 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0) NG00065
downstream A 2.3e-84 IGAP (2013): ADGC Subset NG00053
upstream A 3.4e-84 ADGC Age of Onset LOAD NG00048
downstream C 5.0e-84 ADGC Age of Onset LOAD NG00048
downstream G 1.1e-83 IGAP 2013: Stage 1 NG00036
downstream A 1.1e-82 IGAP 2013: Stage 1 NG00036
downstream T 1.2e-82 IGAP 2013: Stage 1 NG00036
in gene A 1.3e-82 IGAP (2013): ADGC Subset NG00053
upstream G 3.4e-82 IGAP 2013: Stage 1 NG00036
downstream T 4.3e-82 IGAP 2013: Stage 1 NG00036
downstream A 5.1e-82 ADGC Age of Onset LOAD NG00048
in gene N/A 1.1e-81 ADSP Single-Variant Risk Association: meta analysis (Model 0) NG00065
in gene T 1.1e-81 IGAP (2013): ADGC Subset NG00053
in gene T 3.1e-81 IGAP (2013): ADGC Subset NG00053
in gene T 4.6e-81 ADGC Age of Onset LOAD NG00048
in gene A 6.5e-81 IGAP (2013): ADGC Subset NG00053
upstream A 7.8e-81 IGAP 2013: Stage 1 NG00036
in gene C 1.1e-80 IGAP 2013: Stage 1 NG00036
in gene T 1.6e-80 IGAP (2013): ADGC Subset NG00053
in gene T 1.8e-80 AD Age of Onset Survival (IGAP) NG00058
downstream A 1.9e-80 AD Age of Onset Survival (IGAP) NG00058
downstream T 2.3e-80 Transethnic LOAD: All Samples NG00056
downstream A 6.3e-80 AD Age of Onset Survival (IGAP) NG00058
downstream C 1.1e-79 Transethnic LOAD: All Samples NG00056
downstream A 2.8e-79 Transethnic LOAD: All Samples NG00056
downstream T 3.5e-79 IGAP 2013: Stage 1 NG00036
downstream A 4.9e-79 IGAP (2013): ADGC Subset NG00053
upstream A 8.8e-79 ADGC Age of Onset LOAD NG00048
downstream A 1.8e-78 AD Age of Onset Survival (IGAP) NG00058
downstream T 1.9e-77 Transethnic LOAD: All Samples NG00056
upstream A 3.4e-77 AD Age of Onset Survival (IGAP) NG00058
downstream A 1.2e-76 Transethnic LOAD: All Samples NG00056
in gene T 1.6e-76 AD Age of Onset Survival (IGAP) NG00058
in gene A 2.1e-76 IGAP 2013: Stage 1 NG00036
in gene C 2.8e-76 IGAP 2013: Stage 1 NG00036
in gene T 2.8e-76 IGAP 2013: Stage 1 NG00036
in gene T 3.9e-76 AD Age of Onset Survival (IGAP) NG00058
in gene T 2.3e-75 AD Age of Onset Survival (IGAP) NG00058
downstream A 2.4e-75 ADGC Age of Onset LOAD NG00048
downstream T 1.5e-74 ADGC Age of Onset LOAD NG00048
downstream C 2.4e-74 Transethnic LOAD: All Samples NG00056
upstream A 5.8e-74 ADGC 2011: Stages 1 and 2 NG00027
downstream G 4.4e-73 IGAP 2013: Stage 1 NG00036
in gene A 4.5e-73 Transethnic LOAD: All Samples NG00056
downstream A 4.5e-73 ADGC Age of Onset LOAD NG00048
downstream A 1.1e-72 ADGC Age of Onset LOAD NG00048
upstream T 3.9e-72 IGAP 2013: Stage 1 NG00036
downstream T 7.8e-72 Transethnic LOAD: All Samples NG00056
downstream T 9.0e-72 Transethnic LOAD: All Samples NG00056
upstream A 3.2e-71 Transethnic LOAD: All Samples NG00056
downstream A 5.4e-71 IGAP (2013): ADGC Subset NG00053
upstream C 6.0e-71 AD Age of Onset Survival (IGAP) NG00058
upstream A 6.5e-71 AD Age of Onset Survival (IGAP) NG00058
upstream A 8.8e-71 AD Age of Onset Survival (IGAP) NG00058
in gene C 9.5e-71 ADGC Age of Onset LOAD NG00048
in gene T 1.0e-70 AD Age of Onset Survival (IGAP) NG00058
downstream A 1.8e-70 AD Age of Onset Survival (IGAP) NG00058
in gene T 4.3e-70 ADGC Age of Onset LOAD NG00048
downstream C 9.5e-70 Transethnic LOAD: All Samples NG00056
in gene T 1.1e-69 ADGC Age of Onset LOAD NG00048
downstream T 1.7e-69 IGAP (2013): ADGC Subset NG00053
upstream A 2.8e-69 AD Age of Onset Survival (IGAP) NG00058
in gene T 3.0e-69 IGAP 2013: Stage 1 NG00036
downstream A 3.4e-69 ADGC Age of Onset LOAD NG00048
upstream C 3.5e-69 Transethnic LOAD: All Samples NG00056
in gene T 3.8e-69 IGAP 2013: Stage 1 NG00036
in gene C 4.7e-69 IGAP 2013: Stage 1 NG00036
upstream A 4.7e-69 IGAP 2013: Stage 1 NG00036
in gene T 5.4e-69 IGAP 2013: Stage 1 NG00036
downstream A 6.7e-69 ADGC Age of Onset LOAD NG00048
in gene T 7.5e-69 IGAP (2013): ADGC Subset NG00053
in gene T 2.4e-68 IGAP (2013): ADGC Subset NG00053
downstream T 6.3e-68 IGAP 2013: Stage 1 NG00036
in gene A 8.0e-68 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.2e-67 IGAP 2013: Stage 1 NG00036
downstream A 1.6e-67 IGAP (2013): ADGC Subset NG00053
downstream C 1.6e-67 IGAP (2013): ADGC Subset NG00053
in gene T 1.8e-67 IGAP 2013: Stage 1 NG00036
in gene A 2.0e-67 IGAP 2013: Stage 1 NG00036
downstream C 2.3e-67 IGAP 2013: Stage 1 NG00036
in gene A 2.8e-67 ADGC Age of Onset LOAD NG00048
upstream C 2.9e-67 ADGC 2011: Stages 1 and 2 NG00027
upstream T 3.3e-67 IGAP 2013: Stage 1 NG00036
downstream A 3.7e-67 ADGC Age of Onset LOAD NG00048
in gene C 4.6e-67 IGAP (2013): ADGC Subset NG00053
in gene T 4.8e-67 IGAP 2013: Stage 1 NG00036
upstream N/A C 4.9e-67 IGAP 2013: Stage 1 NG00036
in gene C 5.5e-67 IGAP 2013: Stage 1 NG00036
in gene C 1.2e-66 IGAP 2013: Stage 1 NG00036
downstream N/A A 8.9e-66 AD Age of Onset Survival (IGAP) NG00058
upstream C 1.5e-65 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-65 IGAP 2013: Stage 1 NG00036
downstream C 2.0e-65 IGAP 2013: Stage 1 NG00036
downstream T 2.3e-65 AD Age of Onset Survival (IGAP) NG00058
downstream T 3.5e-65 AD Age of Onset Survival (IGAP) NG00058
upstream A 4.1e-65 IGAP 2013: Stage 1 NG00036
downstream A 4.1e-65 IGAP 2013: Stage 1 NG00036
upstream C 4.4e-65 IGAP 2013: Stage 1 NG00036
upstream C 1.4e-64 IGAP 2013: Stage 1 NG00036
upstream T 2.6e-64 IGAP 2013: Stage 1 NG00036
downstream T 4.8e-64 AD Age of Onset Survival (IGAP) NG00058
upstream C 9.3e-64 IGAP 2013: Stage 1 NG00036
downstream T 1.0e-63 ADGC Age of Onset LOAD NG00048
upstream A 1.6e-63 Transethnic LOAD: All Samples NG00056
upstream A 2.2e-63 IGAP 2013: Stage 1 NG00036
upstream A 2.6e-63 IGAP 2013: Stage 1 NG00036
upstream C 1.1e-62 IGAP 2013: Stage 1 NG00036
downstream T 1.6e-62 ADGC Age of Onset LOAD NG00048
upstream C 2.7e-62 IGAP 2013: Stage 1 NG00036
upstream A 2.8e-62 IGAP 2013: Stage 1 NG00036
downstream T 4.6e-62 IGAP 2013: Stage 1 NG00036
in gene T 5.2e-62 ADGC Age of Onset LOAD NG00048
downstream T 2.5e-61 IGAP (2013): ADGC Subset NG00053
upstream G 7.7e-61 IGAP 2013: Stage 1 NG00036
upstream T 1.2e-60 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-60 ADGC Age of Onset LOAD NG00048
downstream T 4.2e-60 IGAP (2013): ADGC Subset NG00053
upstream G 6.2e-60 IGAP 2013: Stage 1 NG00036
downstream A 2.4e-59 IGAP (2013): ADGC Subset NG00053
upstream G 4.8e-59 IGAP 2013: Stage 1 NG00036
in gene A 6.2e-59 ADGC Age of Onset LOAD NG00048
upstream A 1.7e-58 IGAP 2013: Stage 1 NG00036
in gene C 4.8e-58 IGAP 2013: Stage 1 NG00036
in gene A 8.6e-58 IGAP (2013): ADGC Subset NG00053
in gene T 1.1e-57 Transethnic LOAD: All Samples NG00056
in gene A 4.7e-57 Transethnic LOAD: All Samples NG00056
upstream A 6.2e-57 IGAP (2013): ADGC Subset NG00053
downstream A 1.1e-56 Transethnic LOAD: All Samples NG00056
downstream A 1.7e-56 Transethnic LOAD: All Samples NG00056
in gene T 2.8e-56 Transethnic LOAD: All Samples NG00056
downstream T 3.1e-56 ADGC Age of Onset LOAD NG00048
upstream A 7.3e-56 ADGC Age of Onset LOAD NG00048
in gene C 1.1e-55 Transethnic LOAD: All Samples NG00056
in gene T 1.5e-55 Transethnic LOAD: All Samples NG00056
in gene T 3.3e-55 Transethnic LOAD: All Samples NG00056
in gene A 8.5e-55 Transethnic LOAD: All Samples NG00056
upstream C 9.0e-55 IGAP (2013): ADGC Subset NG00053
downstream A 9.2e-55 IGAP (2013): ADGC Subset NG00053
downstream N/A A 1.2e-54 Transethnic LOAD: All Samples NG00056
in gene T 1.3e-54 Transethnic LOAD: All Samples NG00056
in gene A 1.4e-54 ADGC 2011: Stage 1 NG00027
upstream T 3.2e-54 IGAP (2013): ADGC Subset NG00053
upstream T 3.9e-54 IGAP (2013): ADGC Subset NG00053
upstream C 4.8e-54 IGAP (2013): ADGC Subset NG00053
upstream A 2.0e-53 ADGC Age of Onset LOAD NG00048
in gene A 3.1e-53 Transethnic LOAD: All Samples NG00056
in gene T 3.2e-53 Transethnic LOAD: All Samples NG00056
upstream A 5.2e-53 IGAP (2013): ADGC Subset NG00053
upstream A 5.4e-53 IGAP 2013: Stage 1 NG00036
upstream A 5.5e-53 IGAP 2013: Stage 1 NG00036
downstream T 1.3e-52 IGAP (2013): ADGC Subset NG00053
in gene C 1.7e-52 IGAP 2013: Stage 1 NG00036
upstream A 3.2e-52 IGAP (2013): ADGC Subset NG00053
upstream C 3.4e-52 IGAP (2013): ADGC Subset NG00053
upstream T 3.9e-52 IGAP 2013: Stage 1 NG00036
upstream G 5.5e-52 IGAP 2013: Stage 1 NG00036
upstream N/A T 7.8e-52 AD Age of Onset Survival (IGAP) NG00058
upstream T 8.1e-52 AD Age of Onset Survival (IGAP) NG00058
in gene T 8.5e-52 Transethnic LOAD: All Samples NG00056
downstream T 9.1e-52 IGAP (2013): ADGC Subset NG00053
in gene A 1.2e-51 Transethnic LOAD: All Samples NG00056
in gene A 1.2e-51 AD Age of Onset Survival (IGAP) NG00058
upstream T 1.3e-51 Transethnic LOAD: All Samples NG00056
downstream T 2.5e-51 Transethnic LOAD: All Samples NG00056
upstream T 3.9e-51 AD Age of Onset Survival (IGAP) NG00058
upstream A 4.4e-51 Transethnic LOAD: All Samples NG00056
upstream T 4.7e-51 AD Age of Onset Survival (IGAP) NG00058
in gene A 5.7e-51 IGAP (2013): ADGC Subset NG00053
in gene A 1.4e-50 IGAP (2013): ADGC Subset NG00053
downstream A 1.7e-50 IGAP (2013): ADGC Subset NG00053
upstream C 2.1e-50 Transethnic LOAD: All Samples NG00056
in gene A 2.3e-50 IGAP 2013: Stage 1 NG00036
upstream C 2.4e-50 IGAP (2013): ADGC Subset NG00053
upstream A 2.5e-50 ADGC 2011: Stage 1 NG00027
upstream T 3.8e-50 AD Age of Onset Survival (IGAP) NG00058
upstream T 4.0e-50 Transethnic LOAD: All Samples NG00056
upstream C 8.5e-50 Transethnic LOAD: All Samples NG00056
upstream N/A I 1.7e-49 AD Age of Onset Survival (IGAP) NG00058
upstream N/A I 1.7e-49 AD Age of Onset Survival (IGAP) NG00058
upstream A 1.9e-49 Transethnic LOAD: All Samples NG00056
downstream C 1.9e-49 IGAP (2013): ADGC Subset NG00053
downstream T 8.4e-49 IGAP (2013): ADGC Subset NG00053
in gene T 1.3e-48 Transethnic LOAD: All Samples NG00056
in gene A 5.5e-48 ADGC Age of Onset LOAD NG00048
downstream T 1.8e-47 AD Age of Onset Survival (IGAP) NG00058
upstream C 2.7e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream T 3.9e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream C 5.0e-47 ADGC 2011: Stage 1 NG00027
downstream T 5.5e-47 ADGC African Americans 2013 NG00039
upstream T 8.3e-47 IGAP 2013: Stage 1 NG00036
in gene T 3.5e-46 IGAP (2013): ADGC Subset NG00053
in gene A 3.8e-46 IGAP (2013): ADGC Subset NG00053
upstream T 1.3e-45 IGAP 2013: Stage 1 NG00036
upstream T 1.4e-45 Transethnic LOAD: All Samples NG00056
upstream T 1.7e-45 Transethnic LOAD: All Samples NG00056
upstream G 1.8e-45 IGAP 2013: Stage 1 NG00036
upstream T 3.3e-45 Transethnic LOAD: All Samples NG00056
in gene A 5.1e-45 ADGC 2011: Stage 1 NG00027
downstream T 5.6e-45 ADGC 2011: Stage 1 NG00027
upstream N/A T 6.0e-45 IGAP (2013): ADGC Subset NG00053
in gene C 6.1e-45 IGAP (2013): ADGC Subset NG00053
upstream T 7.4e-45 Transethnic LOAD: All Samples NG00056
upstream A 1.4e-44 IGAP 2013: Stage 1 NG00036
upstream C 1.5e-44 Transethnic LOAD: All Samples NG00056
downstream T 3.0e-44 ADGC 2011: Stage 1 NG00027
downstream T 3.5e-44 IGAP (2013): ADGC Subset NG00053
in gene T 4.1e-44 Transethnic LOAD: All Samples NG00056
upstream T 4.3e-44 Transethnic LOAD: All Samples NG00056
upstream N/A T 4.4e-44 Transethnic LOAD: All Samples NG00056
downstream N/A T 5.9e-44 Transethnic LOAD: All Samples NG00056
upstream T 8.7e-44 ADGC 2011: Stages 1 and 2 NG00027
upstream A 1.1e-43 Transethnic LOAD: All Samples NG00056
upstream G 2.5e-43 IGAP 2013: Stage 1 NG00036
upstream A 4.2e-43 IGAP (2013): ADGC Subset NG00053
upstream T 4.7e-42 Transethnic LOAD: All Samples NG00056
in gene A 6.2e-42 Transethnic LOAD: All Samples NG00056
upstream T 7.3e-42 IGAP (2013): ADGC Subset NG00053
in gene A 8.2e-42 IGAP (2013): ADGC Subset NG00053
upstream T 1.0e-41 Transethnic LOAD: All Samples NG00056
upstream A 5.7e-41 Transethnic LOAD: All Samples NG00056
upstream A 5.8e-41 Transethnic LOAD: All Samples NG00056
upstream N/A I 6.9e-41 AD Age of Onset Survival (IGAP) NG00058
upstream A 1.9e-40 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.9e-40 IGAP (2013): ADGC Subset NG00053
downstream T 2.3e-40 IGAP 2013: Stage 1 NG00036
upstream T 2.9e-40 IGAP 2013: Stage 1 NG00036
downstream A 3.4e-40 IGAP 2013: Stage 1 NG00036
upstream T 3.7e-40 Transethnic LOAD: All Samples NG00056
upstream T 4.2e-40 IGAP (2013): ADGC Subset NG00053
upstream A 5.4e-40 Transethnic LOAD: All Samples NG00056
downstream T 1.5e-39 IGAP 2013: Stage 1 NG00036
in gene T 2.0e-39 IGAP (2013): ADGC Subset NG00053
upstream G 2.2e-39 IGAP 2013: Stage 1 NG00036
downstream N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
upstream A 4.7e-39 IGAP (2013): ADGC Subset NG00053
upstream T 1.0e-38 IGAP (2013): ADGC Subset NG00053
upstream A 1.3e-38 IGAP (2013): ADGC Subset NG00053
upstream T 1.4e-38 Transethnic LOAD: All Samples NG00056
upstream T 1.9e-38 Transethnic LOAD: All Samples NG00056
upstream C 2.7e-38 IGAP (2013): ADGC Subset NG00053
upstream T 5.9e-38 IGAP (2013): ADGC Subset NG00053
upstream A 9.9e-38 Transethnic LOAD: All Samples NG00056
upstream T 1.1e-37 AD Age of Onset Survival (IGAP) NG00058
upstream A 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream C 1.8e-37 Transethnic LOAD: All Samples NG00056
in gene T 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream T 2.0e-37 IGAP (2013): ADGC Subset NG00053
in gene T 2.1e-37 IGAP (2013): ADGC Subset NG00053
upstream C 2.4e-37 Transethnic LOAD: All Samples NG00056
in gene T 2.5e-37 IGAP (2013): ADGC Subset NG00053
in gene T 2.7e-37 IGAP (2013): ADGC Subset NG00053
upstream A 5.8e-37 IGAP (2013): ADGC Subset NG00053
upstream C 1.9e-36 IGAP (2013): ADGC Subset NG00053
upstream A 2.1e-36 IGAP (2013): ADGC Subset NG00053
upstream T 3.7e-36 IGAP 2013: Stage 1 NG00036
upstream A 3.8e-36 Transethnic LOAD: All Samples NG00056
downstream A 4.6e-36 IGAP (2013): ADGC Subset NG00053
upstream A 4.9e-36 IGAP (2013): ADGC Subset NG00053
upstream A 5.1e-36 IGAP (2013): ADGC Subset NG00053
upstream A 5.3e-36 IGAP 2013: Stage 1 NG00036
upstream C 6.3e-36 IGAP (2013): ADGC Subset NG00053
downstream T 8.4e-36 IGAP (2013): ADGC Subset NG00053
in gene T 8.9e-36 IGAP (2013): ADGC Subset NG00053
in gene A 9.3e-36 IGAP (2013): ADGC Subset NG00053
upstream A 9.5e-36 Transethnic LOAD: All Samples NG00056
in gene T 1.0e-35 Transethnic LOAD: All Samples NG00056
in gene T 1.1e-35 IGAP (2013): ADGC Subset NG00053
in gene T 1.1e-35 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.2e-35 Transethnic LOAD: All Samples NG00056
upstream T 1.9e-35 IGAP (2013): ADGC Subset NG00053
upstream T 1.9e-35 Transethnic LOAD: All Samples NG00056
upstream A 2.8e-35 Transethnic LOAD: All Samples NG00056
upstream C 3.3e-35 Transethnic LOAD: All Samples NG00056
upstream A 9.3e-35 Transethnic LOAD: All Samples NG00056
in gene T 1.2e-34 IGAP 2013: Stage 1 NG00036
upstream T 5.8e-34 Transethnic LOAD: All Samples NG00056
upstream A 9.1e-34 IGAP (2013): ADGC Subset NG00053
upstream A 1.4e-33 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-33 ADGC 2011: Stage 1 NG00027
upstream T 1.7e-33 IGAP (2013): ADGC Subset NG00053
upstream T 1.8e-33 ADGC 2011: Stage 1 NG00027
upstream A 2.0e-33 Transethnic LOAD: All Samples NG00056
upstream T 2.3e-33 Transethnic LOAD: APOE e4 Carriers NG00056
upstream T 5.5e-33 IGAP 2013: Stage 1 NG00036
upstream T 8.7e-33 IGAP (2013): ADGC Subset NG00053
upstream C 2.4e-32 ADGC 2011: Stage 1 NG00027
upstream T 2.6e-32 Transethnic LOAD: All Samples NG00056
downstream A 3.1e-32 AD Age of Onset Survival (IGAP) NG00058
upstream C 4.7e-32 IGAP 2013: Stage 1 NG00036
upstream C 8.5e-32 AD Age of Onset Survival (IGAP) NG00058
upstream N/A A 1.1e-31 Transethnic LOAD: All Samples NG00056
upstream A 1.3e-31 IGAP 2013: Stage 1 NG00036
upstream A 1.9e-31 AD Age of Onset Survival (IGAP) NG00058
downstream A 2.6e-31 IGAP (2013): ADGC Subset NG00053
upstream A 8.0e-31 AD Age of Onset Survival (IGAP) NG00058
upstream T 9.3e-31 IGAP 2013: Stage 1 NG00036
upstream C 9.7e-31 Transethnic LOAD: All Samples NG00056
upstream A 1.1e-30 Transethnic LOAD: All Samples NG00056
upstream A 1.3e-30 IGAP 2013: Stage 1 NG00036
in gene A 1.4e-30 ADGC Age of Onset LOAD NG00048
upstream T 1.5e-30 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-30 IGAP 2013: Stage 1 NG00036
downstream