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APOE - ENSG00000130203

apolipoprotein E

Location: chr19:45,409,011-45,412,650

Gene Type: protein coding

More information

NCBI Gene: 348
HUGO: HGNC:613
Ensembl: ENSG00000130203
VEGA: OTTHUMG00000128901
OMIM: 107741
UniProtKB: P02649

Genomic Context
Gene-based Trait Associations
Genetic Variation and Variant-based Trait Associations
- Alzheimer's Disease GWAS
- Related Neuropathologies and Other Traits GWAS
Functional Genomics
Functional Annotation

Genomic Context

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Gene-based Trait Associations

ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

Accession	Population	N SNPs	p-value	Sign. Level	rho	CMAF	CMAC	Covariates	Variant Filter	Caveats
NG00065	European	18	3.3e-03	N/A	0	4.8e-03	100.2	PCs and sequencing center	VEP MOD-HIGH	N/A
NG00065	Meta	24	6.9e-03	N/A	0	0.010	224.3	PCs and sequencing center	VEP MOD-HIGH	N/A
NG00065	European	18	0.103	N/A	0	4.8e-03	100.2	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP MOD-HIGH	N/A
NG00065	European	18	0.120	N/A	1	4.8e-03	100.2	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP MOD-HIGH	N/A
NG00065	Meta	24	0.147	N/A	0	0.010	224.3	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP MOD-HIGH	N/A
NG00065	Meta	24	0.201	N/A	0	0.010	224.3	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP MOD-HIGH	N/A
NG00065	Caribbean Hispanic	1	0.353	N/A	0	1.3e-03	1.0	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	LOF
NG00065	Caribbean Hispanic	1	0.353	N/A	0	1.3e-03	1.0	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP HIGH
NG00065	Caribbean Hispanic	7	0.360	N/A	1	0.015	11.8	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP MOD-HIGH	N/A
NG00065	Caribbean Hispanic	7	0.366	N/A	1	0.015	11.8	PCs and sequencing center	VEP MOD-HIGH	N/A
NG00065	Caribbean Hispanic	1	0.373	N/A	0	1.3e-03	1.0	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP HIGH
NG00065	Caribbean Hispanic	1	0.373	N/A	0	1.3e-03	1.0	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	LOF
NG00065	Caribbean Hispanic	7	0.373	N/A	1	0.015	11.8	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP MOD-HIGH	N/A
NG00065	Caribbean Hispanic	1	0.377	N/A	0	1.3e-03	1.0	PCs and sequencing center	VEP HIGH
NG00065	Caribbean Hispanic	1	0.377	N/A	0	1.3e-03	1.0	PCs and sequencing center	LOF
NG00065	European	3	0.406	N/A	0	1.9e-04	4.1	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP HIGH
NG00065	European	3	0.408	N/A	0	1.9e-04	4.0	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	LOF
NG00065	European	3	0.409	N/A	0	1.9e-04	4.1	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP HIGH
NG00065	European	3	0.410	N/A	0	1.9e-04	4.0	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	LOF
NG00065	European	3	0.420	N/A	0	1.9e-04	4.1	PCs and sequencing center	VEP HIGH
NG00065	European	3	0.420	N/A	0	1.9e-04	4.0	PCs and sequencing center	LOF
NG00065	Meta	4	0.445	N/A	1	2.3e-04	5.1	PCs and sequencing center	VEP HIGH
NG00065	Meta	4	0.471	N/A	0	2.3e-04	5.1	PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes	VEP HIGH
NG00065	Meta	4	0.487	N/A	0	2.3e-04	5.1	PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls)	VEP HIGH

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the APOE gene.

The APOE gene contains 464 variants records (corresponding to 420 unique genomic positions).

The following variants, contained within ±100kb of APOE, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of APOE that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10^-8. For exome array studies, a cutoff of p-value < 1 x 10^-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

Relative Position	Variant	ADSP?	Allele	p-Value	Track	Accession
downstream	19:45422946:A:G (rs4420638)		A	0.000	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45392254:C:T (rs6857)		T	2.5e-575	IGAP 2013: Stage 1	NG00036
in gene	19:45411941:T:C (rs429358)		T	1.4e-546	Transethnic LOAD: All Samples	NG00056
in gene	19:45411941:T:C (rs429358)		C	6.7e-536	IGAP 2013: Stage 1	NG00036
in gene	19:45410002:G:A (rs769449)		A	9.9e-523	IGAP 2013: Stage 1	NG00036
downstream	19:45415713:G:A (rs10414043)		A	1.2e-522	IGAP 2013: Stage 1	NG00036
downstream	19:45415935:G:T (rs7256200)		T	1.8e-520	IGAP 2013: Stage 1	NG00036
upstream	19:45396665:G:T (rs59007384)		T	2.0e-486	IGAP 2013: Stage 1	NG00036
downstream	19:45422160:C:G (rs12721051)		G	7.8e-482	IGAP 2013: Stage 1	NG00036
upstream	19:45394969:T:G (rs184017)		G	8.5e-475	IGAP 2013: Stage 1	NG00036
upstream	19:45395714:T:C (rs157581)		C	8.9e-469	IGAP 2013: Stage 1	NG00036
upstream	19:45395909:C:G (rs34404554)		G	6.4e-466	IGAP 2013: Stage 1	NG00036
upstream	19:45396144:C:T (rs11556505)		T	2.6e-464	IGAP 2013: Stage 1	NG00036
upstream	19:45395619:A:G (rs2075650)		G	5.1e-464	IGAP 2013: Stage 1	NG00036
upstream	19:45394336:T:C (rs71352238)		C	2.5e-462	IGAP 2013: Stage 1	NG00036
downstream	19:45422846:G:A (rs56131196)		A	2.0e-454	IGAP 2013: Stage 1	NG00036
upstream	19:45390333:A:G (rs283815)		G	6.5e-442	IGAP 2013: Stage 1	NG00036
upstream	19:45388130:G:A (rs34342646)		A	4.9e-440	IGAP 2013: Stage 1	NG00036
downstream	19:45422160:C:G (rs12721051)		C	3.8e-439	Transethnic LOAD: All Samples	NG00056
in gene	19:45410002:G:A (rs769449)		A	5.3e-435	Transethnic LOAD: All Samples	NG00056
upstream	19:45388500:A:G (rs283811)		G	2.7e-434	IGAP 2013: Stage 1	NG00036
upstream	19:45387459:C:G (rs12972156)		G	3.2e-434	IGAP 2013: Stage 1	NG00036
upstream	19:45396219:C:T (rs157582)		T	9.7e-434	IGAP 2013: Stage 1	NG00036
upstream	19:45387596:G:A (rs12972970)		A	5.4e-432	IGAP 2013: Stage 1	NG00036
downstream	19:45428234:G:A (rs66626994)		A	2.5e-427	IGAP 2013: Stage 1	NG00036
downstream	19:45421254:G:A (rs12721046)		A	1.1e-421	IGAP 2013: Stage 1	NG00036
upstream	19:45392254:C:T (rs6857)		T	4.4e-419	Transethnic LOAD: All Samples	NG00056
downstream	19:45422946:A:G (rs4420638)		A	6.3e-411	Transethnic LOAD: All Samples	NG00056
downstream	19:45422846:G:A (rs56131196)		A	2.2e-410	Transethnic LOAD: All Samples	NG00056
downstream	19:45427125:T:A (rs111789331)		A	7.0e-405	IGAP 2013: Stage 1	NG00036
downstream	19:45422946:A:G (rs4420638)		G	1.7e-396	IGAP 2013: Stage 1	NG00036
downstream	19:45418790:T:C (rs5117)		C	8.6e-390	IGAP 2013: Stage 1	NG00036
downstream	19:45420082:A:C (rs73052335)		A	1.0e-385	Transethnic LOAD: All Samples	NG00056
downstream	19:45416178:G:T (rs483082)		T	2.1e-373	IGAP 2013: Stage 1	NG00036
downstream	19:45421254:G:A (rs12721046)		A	3.5e-359	Transethnic LOAD: All Samples	NG00056
in gene	19:45411941:T:C (rs429358)		T	6.6e-357	IGAP (2013): ADGC Subset	NG00053
upstream	19:45392254:C:T (rs6857)		T	7.5e-357	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395844:G:A (rs34095326)		A	3.2e-354	IGAP 2013: Stage 1	NG00036
downstream	19:45415935:G:T (rs7256200)		T	6.3e-353	Transethnic LOAD: All Samples	NG00056
downstream	19:45427125:T:A (rs111789331)		A	3.5e-352	Transethnic LOAD: All Samples	NG00056
downstream	19:45415713:G:A (rs10414043)		A	6.1e-352	Transethnic LOAD: All Samples	NG00056
upstream	19:45387459:C:G (rs12972156)		C	9.0e-350	Transethnic LOAD: All Samples	NG00056
upstream	19:45387596:G:A (rs12972970)		A	1.2e-349	Transethnic LOAD: All Samples	NG00056
upstream	19:45388130:G:A (rs34342646)		A	7.7e-349	Transethnic LOAD: All Samples	NG00056
upstream	19:45394336:T:C (rs71352238)		T	4.4e-344	Transethnic LOAD: All Samples	NG00056
upstream	19:45406673:G:A (rs10119)		A	1.2e-342	IGAP 2013: Stage 1	NG00036
upstream	19:45390333:A:G (rs283815)		A	1.2e-339	Transethnic LOAD: All Samples	NG00056
upstream	19:45395909:C:G (rs34404554)		C	2.6e-336	Transethnic LOAD: All Samples	NG00056
upstream	19:45396219:C:T (rs157582)		T	2.5e-335	Transethnic LOAD: All Samples	NG00056
upstream	19:45388568:T:C (rs283812)	N/A	T	3.0e-333	Transethnic LOAD: All Samples	NG00056
downstream	19:45422160:C:G (rs12721051)		C	7.6e-333	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395714:T:C (rs157581)		T	1.4e-332	Transethnic LOAD: All Samples	NG00056
upstream	19:45394969:T:G (rs184017)		T	9.6e-331	Transethnic LOAD: All Samples	NG00056
upstream	19:45396144:C:T (rs11556505)		T	1.6e-327	Transethnic LOAD: All Samples	NG00056
downstream	19:45413576:C:T (rs75627662)		T	2.8e-326	IGAP 2013: Stage 1	NG00036
downstream	19:45422846:G:A (rs56131196)		A	4.3e-326	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395619:A:G (rs2075650)		A	3.1e-317	Transethnic LOAD: All Samples	NG00056
in gene	19:45410002:G:A (rs769449)		A	1.4e-313	IGAP (2013): ADGC Subset	NG00053
downstream	19:45415713:G:A (rs10414043)		A	3.4e-311	IGAP (2013): ADGC Subset	NG00053
downstream	19:45415935:G:T (rs7256200)		T	1.2e-310	IGAP (2013): ADGC Subset	NG00053
downstream	19:45428234:G:A (rs66626994)		A	2.2e-309	Transethnic LOAD: All Samples	NG00056
downstream	19:45416741:C:T (rs438811)		T	1.5e-307	Transethnic LOAD: All Samples	NG00056
upstream	19:45396665:G:T (rs59007384)		T	2.8e-300	IGAP (2013): ADGC Subset	NG00053
upstream	19:45388500:A:G (rs283811)		A	7.1e-300	Transethnic LOAD: All Samples	NG00056
upstream	19:45396665:G:T (rs59007384)		T	1.2e-298	Transethnic LOAD: All Samples	NG00056
upstream	19:45406673:G:A (rs10119)		A	8.8e-297	Transethnic LOAD: All Samples	NG00056
upstream	19:45394969:T:G (rs184017)		T	1.8e-294	IGAP (2013): ADGC Subset	NG00053
downstream	19:45416178:G:T (rs483082)		T	1.7e-291	Transethnic LOAD: All Samples	NG00056
downstream	19:45428234:G:A (rs66626994)		A	8.0e-291	IGAP (2013): ADGC Subset	NG00053
downstream	19:45421254:G:A (rs12721046)		A	1.8e-290	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395714:T:C (rs157581)		T	6.4e-290	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395909:C:G (rs34404554)		C	4.5e-288	IGAP (2013): ADGC Subset	NG00053
upstream	19:45396144:C:T (rs11556505)		T	1.7e-286	IGAP (2013): ADGC Subset	NG00053
downstream	19:45427125:T:A (rs111789331)		A	4.9e-286	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395619:A:G (rs2075650)		A	1.5e-285	IGAP (2013): ADGC Subset	NG00053
upstream	19:45394336:T:C (rs71352238)		T	3.3e-285	IGAP (2013): ADGC Subset	NG00053
upstream	19:45390333:A:G (rs283815)		A	2.0e-273	IGAP (2013): ADGC Subset	NG00053
upstream	19:45388130:G:A (rs34342646)		A	1.6e-270	IGAP (2013): ADGC Subset	NG00053
upstream	19:45388500:A:G (rs283811)		A	2.9e-268	IGAP (2013): ADGC Subset	NG00053
downstream	19:45422946:A:G (rs4420638)		A	1.1e-266	ADGC 2011: Stage 1	NG00027
upstream	19:45387459:C:G (rs12972156)		C	1.3e-263	IGAP (2013): ADGC Subset	NG00053
upstream	19:45387596:G:A (rs12972970)		A	3.0e-263	IGAP (2013): ADGC Subset	NG00053
downstream	19:45418790:T:C (rs5117)		T	1.7e-260	Transethnic LOAD: All Samples	NG00056
upstream	19:45396219:C:T (rs157582)		T	3.0e-254	IGAP (2013): ADGC Subset	NG00053
downstream	19:45422946:A:G (rs4420638)		A	5.7e-243	IGAP (2013): ADGC Subset	NG00053
downstream	19:45416178:G:T (rs483082)		T	2.8e-239	IGAP (2013): ADGC Subset	NG00053
downstream	19:45418790:T:C (rs5117)		T	2.1e-232	IGAP (2013): ADGC Subset	NG00053
upstream	19:45406673:G:A (rs10119)		A	3.1e-226	IGAP (2013): ADGC Subset	NG00053
downstream	19:45424351:A:T (rs814573)	N/A	A	3.5e-224	Transethnic LOAD: All Samples	NG00056
upstream	19:45395844:G:A (rs34095326)		A	8.2e-216	Transethnic LOAD: All Samples	NG00056
upstream	19:45395844:G:A (rs34095326)		A	6.4e-212	IGAP (2013): ADGC Subset	NG00053
downstream	19:45413576:C:T (rs75627662)		T	1.7e-210	Transethnic LOAD: All Samples	NG00056
upstream	19:45392254:C:T (rs6857)		T	2.2e-206	ADGC 2011: Stage 1	NG00027
downstream	19:45413576:C:T (rs75627662)		T	1.4e-204	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395619:A:G (rs2075650)		A	6.2e-184	ADGC 2011: Stage 1	NG00027
upstream	19:45396219:C:T (rs157582)		T	8.2e-178	ADGC 2011: Stage 1	NG00027
upstream	19:45351516:C:G (rs41289512)		G	2.2e-167	IGAP 2013: Stage 1	NG00036
downstream	19:45418486:G:A (rs12691088)		A	1.7e-134	IGAP 2013: Stage 1	NG00036
upstream	19:45395619:A:G (rs2075650)		A	6.0e-134	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45396144:C:T (rs11556505)		T	1.4e-133	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45405062:A:G (rs1038026)		A	1.9e-133	Transethnic LOAD: All Samples	NG00056
upstream	19:45395909:C:G (rs34404554)		C	3.0e-133	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45394336:T:C (rs71352238)		T	4.9e-133	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45403858:A:G (rs760136)		A	2.2e-132	Transethnic LOAD: All Samples	NG00056
upstream	19:45403412:C:T (rs1160985)		T	4.7e-132	Transethnic LOAD: All Samples	NG00056
upstream	19:45404972:T:C (rs1038025)		T	9.5e-132	Transethnic LOAD: All Samples	NG00056
in gene	19:45411941:T:C (rs429358)		T	4.3e-131	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45406673:G:A (rs10119)		A	1.1e-128	ADGC 2011: Stage 1	NG00027
upstream	19:45403858:A:G (rs760136)		G	1.7e-128	IGAP 2013: Stage 1	NG00036
upstream	19:45404431:T:C (rs741780)		T	3.6e-128	Transethnic LOAD: All Samples	NG00056
upstream	19:45404431:T:C (rs741780)		C	2.3e-127	IGAP 2013: Stage 1	NG00036
upstream	19:45404972:T:C (rs1038025)		C	1.0e-126	IGAP 2013: Stage 1	NG00036
upstream	19:45405062:A:G (rs1038026)		G	1.7e-126	IGAP 2013: Stage 1	NG00036
upstream	19:45407788:G:A (rs7259620)		A	3.0e-125	Transethnic LOAD: All Samples	NG00056
upstream	19:45407788:G:A (rs7259620)		A	3.3e-125	IGAP 2013: Stage 1	NG00036
upstream	19:45403412:C:T (rs1160985)		T	6.2e-125	IGAP 2013: Stage 1	NG00036
upstream	19:45396144:C:T (rs11556505)		N/A	2.8e-122	ADSP Single-Variant Risk Association: European (Model 0)	NG00065
upstream	19:45396144:C:T (rs11556505)		N/A	2.8e-122	ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0)	NG00065
downstream	19:45422946:A:G (rs4420638)		A	3.8e-121	ADGC 2011: Stage 2	NG00027
upstream	19:45396144:C:T (rs11556505)		N/A	2.0e-117	ADSP Single-Variant Risk Association: meta analysis (Model 0)	NG00065
downstream	19:45418486:G:A (rs12691088)		A	8.1e-116	IGAP (2013): ADGC Subset	NG00053
upstream	19:45402477:C:T (rs34878901)		T	3.5e-115	IGAP 2013: Stage 1	NG00036
upstream	19:45401666:A:G (rs8106922)		G	2.0e-114	IGAP 2013: Stage 1	NG00036
upstream	19:45398817:C:T (rs2238681)		T	4.8e-114	IGAP 2013: Stage 1	NG00036
upstream	19:45405521:G:C (rs1305062)		C	3.2e-112	IGAP 2013: Stage 1	NG00036
downstream	19:45421100:G:A (rs3925681)		A	9.0e-109	IGAP 2013: Stage 1	NG00036
upstream	19:45365447:G:A (rs146275714)		A	1.5e-108	IGAP 2013: Stage 1	NG00036
in gene	19:45410002:G:A (rs769449)		A	6.8e-106	AD Age of Onset Survival (IGAP)	NG00058
in gene	19:45410444:G:A (rs769450)		A	5.1e-104	IGAP 2013: Stage 1	NG00036
upstream	19:45351516:C:G (rs41289512)		C	1.9e-103	IGAP (2013): ADGC Subset	NG00053
downstream	19:45415713:G:A (rs10414043)		A	3.0e-102	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45395266:G:A (rs157580)		G	1.2e-101	IGAP 2013: Stage 1	NG00036
in gene	19:45410444:G:A (rs769450)		A	1.4e-101	Transethnic LOAD: All Samples	NG00056
downstream	19:45415935:G:T (rs7256200)		T	1.4e-101	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45422946:A:G (rs4420638)		A	2.2e-101	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45422846:G:A (rs56131196)		A	2.3e-101	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45425460:A:G (rs157595)		A	3.8e-101	IGAP 2013: Stage 1	NG00036
downstream	19:45422160:C:G (rs12721051)		C	1.3e-100	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45421100:G:A (rs3925681)		A	4.8e-100	Transethnic LOAD: All Samples	NG00056
upstream	19:45408836:T:G (rs405509)		T	2.3e-99	Transethnic LOAD: All Samples	NG00056
upstream	19:45405521:G:C (rs1305062)		C	8.3e-99	Transethnic LOAD: All Samples	NG00056
upstream	19:45365447:G:A (rs146275714)		A	2.0e-98	IGAP (2013): ADGC Subset	NG00053
upstream	19:45402477:C:T (rs34878901)		T	9.1e-98	Transethnic LOAD: All Samples	NG00056
upstream	19:45395330:A:G (rs2075649)		G	5.4e-97	IGAP 2013: Stage 1	NG00036
upstream	19:45401666:A:G (rs8106922)		A	8.5e-97	Transethnic LOAD: All Samples	NG00056
upstream	19:45392254:C:T (rs6857)		T	3.3e-96	ADGC Age of Onset LOAD	NG00048
upstream	19:45382034:A:G (rs6859)		A	3.3e-96	IGAP 2013: Stage 1	NG00036
upstream	19:45392254:C:T (rs6857)		T	3.7e-96	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45395266:G:A (rs157580)		A	2.0e-95	Transethnic LOAD: All Samples	NG00056
downstream	19:45420082:A:C (rs73052335)		A	3.8e-95	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45398817:C:T (rs2238681)		T	1.2e-94	Transethnic LOAD: All Samples	NG00056
upstream	19:45396665:G:T (rs59007384)		T	1.1e-93	ADGC Age of Onset LOAD	NG00048
upstream	19:45394969:T:G (rs184017)		T	3.5e-93	ADGC Age of Onset LOAD	NG00048
downstream	19:45425460:A:G (rs157595)		A	1.3e-92	Transethnic LOAD: All Samples	NG00056
downstream	19:45416291:C:T (rs59325138)		T	6.9e-89	IGAP 2013: Stage 1	NG00036
in gene	19:45411941:T:C (rs429358)		T	8.1e-89	ADGC Age of Onset LOAD	NG00048
upstream	19:45357291:G:C (rs4803763)		C	9.9e-89	IGAP 2013: Stage 1	NG00036
downstream	19:45428459:C:T (rs4803772)		T	1.3e-88	IGAP 2013: Stage 1	NG00036
upstream	19:45357377:T:C (rs4803764)		C	4.2e-87	IGAP 2013: Stage 1	NG00036
upstream	19:45395266:G:A (rs157580)		A	5.4e-87	IGAP (2013): ADGC Subset	NG00053
upstream	19:45357003:C:G (rs35396326)		G	1.4e-86	IGAP 2013: Stage 1	NG00036
downstream	19:45416291:C:T (rs59325138)		T	3.0e-86	Transethnic LOAD: All Samples	NG00056
upstream	19:45359586:C:T (rs56317818)		T	1.8e-85	IGAP 2013: Stage 1	NG00036
upstream	19:45385759:G:C (rs3745150)		C	2.8e-85	IGAP 2013: Stage 1	NG00036
downstream	19:45421877:A:G (rs484195)		A	2.9e-85	Transethnic LOAD: All Samples	NG00056
upstream	19:45356464:T:A (rs73050205)		A	2.9e-85	IGAP 2013: Stage 1	NG00036
downstream	19:45423636:G:A (rs78959900)		A	3.9e-85	IGAP 2013: Stage 1	NG00036
downstream	19:45425175:T:G (rs157594)		T	9.0e-85	Transethnic LOAD: All Samples	NG00056
upstream	19:45388568:T:C (rs283812)	N/A	T	1.1e-84	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45395714:T:C (rs157581)		N/A	1.7e-84	ADSP Single-Variant Risk Association: European (Model 0)	NG00065
upstream	19:45395714:T:C (rs157581)		N/A	1.7e-84	ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0)	NG00065
downstream	19:45425460:A:G (rs157595)		A	2.3e-84	IGAP (2013): ADGC Subset	NG00053
upstream	19:45390333:A:G (rs283815)		A	3.4e-84	ADGC Age of Onset LOAD	NG00048
downstream	19:45422160:C:G (rs12721051)		C	5.0e-84	ADGC Age of Onset LOAD	NG00048
downstream	19:45427353:C:G (rs4803770)		G	1.1e-83	IGAP 2013: Stage 1	NG00036
downstream	19:45416478:A:G (rs584007)		A	1.1e-82	IGAP 2013: Stage 1	NG00036
downstream	19:45421744:G:T (rs12721056)		T	1.2e-82	IGAP 2013: Stage 1	NG00036
upstream	19:45403858:A:G (rs760136)		A	1.3e-82	IGAP (2013): ADGC Subset	NG00053
upstream	19:45355721:C:G (rs2972559)		G	3.4e-82	IGAP 2013: Stage 1	NG00036
downstream	19:45425175:T:G (rs157594)		T	4.3e-82	IGAP 2013: Stage 1	NG00036
downstream	19:45422846:G:A (rs56131196)		A	5.1e-82	ADGC Age of Onset LOAD	NG00048
upstream	19:45395714:T:C (rs157581)		N/A	1.1e-81	ADSP Single-Variant Risk Association: meta analysis (Model 0)	NG00065
upstream	19:45404431:T:C (rs741780)		T	1.1e-81	IGAP (2013): ADGC Subset	NG00053
upstream	19:45404972:T:C (rs1038025)		T	3.1e-81	IGAP (2013): ADGC Subset	NG00053
upstream	19:45395714:T:C (rs157581)		T	4.6e-81	ADGC Age of Onset LOAD	NG00048
upstream	19:45405062:A:G (rs1038026)		A	6.5e-81	IGAP (2013): ADGC Subset	NG00053
upstream	19:45359706:G:A (rs12462573)		A	7.8e-81	IGAP 2013: Stage 1	NG00036
upstream	19:45398716:A:C (rs157590)		C	1.1e-80	IGAP 2013: Stage 1	NG00036
upstream	19:45403412:C:T (rs1160985)		T	1.6e-80	IGAP (2013): ADGC Subset	NG00053
upstream	19:45396665:G:T (rs59007384)		T	1.8e-80	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45427125:T:A (rs111789331)		A	1.9e-80	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45414451:T:C (rs439401)		T	2.3e-80	Transethnic LOAD: All Samples	NG00056
downstream	19:45428234:G:A (rs66626994)		A	6.3e-80	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45427353:C:G (rs4803770)		C	1.1e-79	Transethnic LOAD: All Samples	NG00056
downstream	19:45416478:A:G (rs584007)		A	2.8e-79	Transethnic LOAD: All Samples	NG00056
downstream	19:45414451:T:C (rs439401)		T	3.5e-79	IGAP 2013: Stage 1	NG00036
upstream	19:45407788:G:A (rs7259620)		A	4.9e-79	IGAP (2013): ADGC Subset	NG00053
upstream	19:45388500:A:G (rs283811)		A	8.8e-79	ADGC Age of Onset LOAD	NG00048
downstream	19:45421254:G:A (rs12721046)		A	1.8e-78	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45421744:G:T (rs12721056)		T	1.9e-77	Transethnic LOAD: All Samples	NG00056
upstream	19:45390333:A:G (rs283815)		A	3.4e-77	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45423636:G:A (rs78959900)		A	1.2e-76	Transethnic LOAD: All Samples	NG00056
upstream	19:45396219:C:T (rs157582)		T	1.6e-76	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45396973:G:A (rs77301115)		A	2.1e-76	IGAP 2013: Stage 1	NG00036
upstream	19:45397512:A:C (rs157585)		C	2.8e-76	IGAP 2013: Stage 1	NG00036
upstream	19:45398264:C:T (rs157588)		T	2.8e-76	IGAP 2013: Stage 1	NG00036
upstream	19:45395714:T:C (rs157581)		T	3.9e-76	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45394969:T:G (rs184017)		T	2.3e-75	AD Age of Onset Survival (IGAP)	NG00058
in gene	19:45410002:G:A (rs769449)		A	2.4e-75	ADGC Age of Onset LOAD	NG00048
downstream	19:45416178:G:T (rs483082)		T	1.5e-74	ADGC Age of Onset LOAD	NG00048
downstream	19:45429708:G:C (rs60049679)		C	2.4e-74	Transethnic LOAD: All Samples	NG00056
upstream	19:45382034:A:G (rs6859)		A	5.8e-74	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45408836:T:G (rs405509)		G	4.4e-73	IGAP 2013: Stage 1	NG00036
upstream	19:45395330:A:G (rs2075649)		A	4.5e-73	Transethnic LOAD: All Samples	NG00056
downstream	19:45422946:A:G (rs4420638)		A	4.5e-73	ADGC Age of Onset LOAD	NG00048
downstream	19:45415713:G:A (rs10414043)		A	1.1e-72	ADGC Age of Onset LOAD	NG00048
upstream	19:45348522:G:T (rs12162222)		T	3.9e-72	IGAP 2013: Stage 1	NG00036
downstream	19:45428459:C:T (rs4803772)		T	7.8e-72	Transethnic LOAD: All Samples	NG00056
downstream	19:45418961:T:C (rs3826688)		T	9.0e-72	Transethnic LOAD: All Samples	NG00056
upstream	19:45382034:A:G (rs6859)		A	3.2e-71	Transethnic LOAD: All Samples	NG00056
downstream	19:45416478:A:G (rs584007)		A	5.4e-71	IGAP (2013): ADGC Subset	NG00053
upstream	19:45387459:C:G (rs12972156)		C	6.0e-71	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45387596:G:A (rs12972970)		A	6.5e-71	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45388130:G:A (rs34342646)		A	8.8e-71	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45395909:C:G (rs34404554)		C	9.5e-71	ADGC Age of Onset LOAD	NG00048
upstream	19:45404857:T:C (rs112019714)		T	1.0e-70	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45412955:A:C (rs1081105)		A	1.8e-70	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45394336:T:C (rs71352238)		T	4.3e-70	ADGC Age of Onset LOAD	NG00048
in gene	19:45409167:C:G (rs440446)		C	9.5e-70	Transethnic LOAD: All Samples	NG00056
upstream	19:45396219:C:T (rs157582)		T	1.1e-69	ADGC Age of Onset LOAD	NG00048
downstream	19:45414451:T:C (rs439401)		T	1.7e-69	IGAP (2013): ADGC Subset	NG00053
upstream	19:45388500:A:G (rs283811)		A	2.8e-69	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45399344:G:T (rs75687619)		T	3.0e-69	IGAP 2013: Stage 1	NG00036
downstream	19:45427125:T:A (rs111789331)		A	3.4e-69	ADGC Age of Onset LOAD	NG00048
upstream	19:45385759:G:C (rs3745150)		C	3.5e-69	Transethnic LOAD: All Samples	NG00056
upstream	19:45398785:C:T (rs79398853)		T	3.8e-69	IGAP 2013: Stage 1	NG00036
upstream	19:45397952:T:C (rs116881820)		C	4.7e-69	IGAP 2013: Stage 1	NG00036
upstream	19:45324138:G:A (rs28399637)		A	4.7e-69	IGAP 2013: Stage 1	NG00036
upstream	19:45397307:C:T (rs112849259)		T	5.4e-69	IGAP 2013: Stage 1	NG00036
downstream	19:45428234:G:A (rs66626994)		A	6.7e-69	ADGC Age of Onset LOAD	NG00048
upstream	19:45402477:C:T (rs34878901)		T	7.5e-69	IGAP (2013): ADGC Subset	NG00053
upstream	19:45398817:C:T (rs2238681)		T	2.4e-68	IGAP (2013): ADGC Subset	NG00053
downstream	19:45418961:T:C (rs3826688)		T	6.3e-68	IGAP 2013: Stage 1	NG00036
upstream	19:45401666:A:G (rs8106922)		A	8.0e-68	IGAP (2013): ADGC Subset	NG00053
upstream	19:45327423:G:T (rs4803758)	N/A	T	1.2e-67	IGAP 2013: Stage 1	NG00036
downstream	19:45421100:G:A (rs3925681)		A	1.6e-67	IGAP (2013): ADGC Subset	NG00053
in gene	19:45409167:C:G (rs440446)		C	1.6e-67	IGAP (2013): ADGC Subset	NG00053
upstream	19:45400725:C:T (rs114536010)		T	1.8e-67	IGAP 2013: Stage 1	NG00036
upstream	19:45399896:G:A (rs76366838)		A	2.0e-67	IGAP 2013: Stage 1	NG00036
in gene	19:45409167:C:G (rs440446)		C	2.3e-67	IGAP 2013: Stage 1	NG00036
upstream	19:45395619:A:G (rs2075650)		A	2.8e-67	ADGC Age of Onset LOAD	NG00048
upstream	19:45357291:G:C (rs4803763)		C	2.9e-67	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45327309:C:T (rs10412413)		T	3.3e-67	IGAP 2013: Stage 1	NG00036
downstream	19:45421254:G:A (rs12721046)		A	3.7e-67	ADGC Age of Onset LOAD	NG00048
upstream	19:45405521:G:C (rs1305062)		C	4.6e-67	IGAP (2013): ADGC Subset	NG00053
upstream	19:45403216:C:T (rs115881343)		T	4.8e-67	IGAP 2013: Stage 1	NG00036
upstream	19:45384405:T:C (rs73052307)	N/A	C	4.9e-67	IGAP 2013: Stage 1	NG00036
upstream	19:45404857:T:C (rs112019714)		C	5.5e-67	IGAP 2013: Stage 1	NG00036
upstream	19:45396899:T:C (rs157584)		C	1.2e-66	IGAP 2013: Stage 1	NG00036
downstream	19:45424351:A:T (rs814573)	N/A	A	8.9e-66	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45337504:G:C (rs11667241)		C	1.5e-65	IGAP 2013: Stage 1	NG00036
upstream	19:45336443:G:A (rs3021439)		A	1.8e-65	IGAP 2013: Stage 1	NG00036
downstream	19:45412955:A:C (rs1081105)		C	2.0e-65	IGAP 2013: Stage 1	NG00036
downstream	19:45416741:C:T (rs438811)		T	2.3e-65	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45416178:G:T (rs483082)		T	3.5e-65	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45345623:G:A (rs2199575)		A	4.1e-65	IGAP 2013: Stage 1	NG00036
downstream	19:45421877:A:G (rs484195)		A	4.1e-65	IGAP 2013: Stage 1	NG00036
upstream	19:45336035:T:C (rs7359852)		C	4.4e-65	IGAP 2013: Stage 1	NG00036
upstream	19:45326217:T:C (rs10406338)		C	1.4e-64	IGAP 2013: Stage 1	NG00036
upstream	19:45328367:A:T (rs58132661)		T	2.6e-64	IGAP 2013: Stage 1	NG00036
downstream	19:45418790:T:C (rs5117)		T	4.8e-64	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45329344:T:C (rs10402524)		C	9.3e-64	IGAP 2013: Stage 1	NG00036
downstream	19:45415935:G:T (rs7256200)		T	1.0e-63	ADGC Age of Onset LOAD	NG00048
upstream	19:45324138:G:A (rs28399637)		A	1.6e-63	Transethnic LOAD: All Samples	NG00056
upstream	19:45337249:C:A (rs2927481)		A	2.2e-63	IGAP 2013: Stage 1	NG00036
upstream	19:45341904:G:A (rs12459575)		A	2.6e-63	IGAP 2013: Stage 1	NG00036
upstream	19:45342007:G:C (rs74579864)		C	1.1e-62	IGAP 2013: Stage 1	NG00036
downstream	19:45413576:C:T (rs75627662)		T	1.6e-62	ADGC Age of Onset LOAD	NG00048
upstream	19:45338523:G:C (rs73048288)		C	2.7e-62	IGAP 2013: Stage 1	NG00036
upstream	19:45342161:G:A (rs4803762)		A	2.8e-62	IGAP 2013: Stage 1	NG00036
downstream	19:45429543:C:T (rs71352239)		T	4.6e-62	IGAP 2013: Stage 1	NG00036
upstream	19:45396144:C:T (rs11556505)		T	5.2e-62	ADGC Age of Onset LOAD	NG00048
downstream	19:45418961:T:C (rs3826688)		T	2.5e-61	IGAP (2013): ADGC Subset	NG00053
upstream	19:45341540:A:G (rs12462274)		G	7.7e-61	IGAP 2013: Stage 1	NG00036
upstream	19:45326664:C:T (rs10405693)		T	1.2e-60	IGAP 2013: Stage 1	NG00036
upstream	19:45387459:C:G (rs12972156)		C	1.6e-60	ADGC Age of Onset LOAD	NG00048
downstream	19:45425175:T:G (rs157594)		T	4.2e-60	IGAP (2013): ADGC Subset	NG00053
upstream	19:45329214:T:G (rs10402271)		G	6.2e-60	IGAP 2013: Stage 1	NG00036
in gene	19:45410444:G:A (rs769450)		A	2.4e-59	IGAP (2013): ADGC Subset	NG00053
upstream	19:45342114:A:G (rs4803761)		G	4.8e-59	IGAP 2013: Stage 1	NG00036
upstream	19:45406673:G:A (rs10119)		A	6.2e-59	ADGC Age of Onset LOAD	NG00048
upstream	19:45357939:A:G (rs2927468)		A	1.7e-58	IGAP 2013: Stage 1	NG00036
upstream	19:45398633:G:C (rs11668327)		C	4.8e-58	IGAP 2013: Stage 1	NG00036
upstream	19:45395330:A:G (rs2075649)		A	8.6e-58	IGAP (2013): ADGC Subset	NG00053
upstream	19:45404857:T:C (rs112019714)		T	1.1e-57	Transethnic LOAD: All Samples	NG00056
upstream	19:45396973:G:A (rs77301115)		A	4.7e-57	Transethnic LOAD: All Samples	NG00056
upstream	19:45382034:A:G (rs6859)		A	6.2e-57	IGAP (2013): ADGC Subset	NG00053
downstream	19:45412955:A:C (rs1081105)		A	1.1e-56	Transethnic LOAD: All Samples	NG00056
downstream	19:45421650:G:A (rs140480140)		A	1.7e-56	Transethnic LOAD: All Samples	NG00056
upstream	19:45403216:C:T (rs115881343)		T	2.8e-56	Transethnic LOAD: All Samples	NG00056
downstream	19:45418790:T:C (rs5117)		T	3.1e-56	ADGC Age of Onset LOAD	NG00048
upstream	19:45388130:G:A (rs34342646)		A	7.3e-56	ADGC Age of Onset LOAD	NG00048
upstream	19:45398633:G:C (rs11668327)		C	1.1e-55	Transethnic LOAD: All Samples	NG00056
upstream	19:45400725:C:T (rs114536010)		T	1.5e-55	Transethnic LOAD: All Samples	NG00056
upstream	19:45399344:G:T (rs75687619)		T	3.3e-55	Transethnic LOAD: All Samples	NG00056
upstream	19:45399896:G:A (rs76366838)		A	8.5e-55	Transethnic LOAD: All Samples	NG00056
upstream	19:45357291:G:C (rs4803763)		C	9.0e-55	IGAP (2013): ADGC Subset	NG00053
downstream	19:45421877:A:G (rs484195)		A	9.2e-55	IGAP (2013): ADGC Subset	NG00053
downstream	19:45425066:G:A (rs188535946)	N/A	A	1.2e-54	Transethnic LOAD: All Samples	NG00056
upstream	19:45397307:C:T (rs112849259)		T	1.3e-54	Transethnic LOAD: All Samples	NG00056
upstream	19:45395266:G:A (rs157580)		A	1.4e-54	ADGC 2011: Stage 1	NG00027
upstream	19:45359586:C:T (rs56317818)		T	3.2e-54	IGAP (2013): ADGC Subset	NG00053
upstream	19:45357377:T:C (rs4803764)		T	3.9e-54	IGAP (2013): ADGC Subset	NG00053
upstream	19:45357003:C:G (rs35396326)		C	4.8e-54	IGAP (2013): ADGC Subset	NG00053
upstream	19:45387596:G:A (rs12972970)		A	2.0e-53	ADGC Age of Onset LOAD	NG00048
upstream	19:45398716:A:C (rs157590)		A	3.1e-53	Transethnic LOAD: All Samples	NG00056
upstream	19:45398785:C:T (rs79398853)		T	3.2e-53	Transethnic LOAD: All Samples	NG00056
upstream	19:45356464:T:A (rs73050205)		A	5.2e-53	IGAP (2013): ADGC Subset	NG00053
upstream	19:45328379:T:A (rs58826447)		A	5.4e-53	IGAP 2013: Stage 1	NG00036
upstream	19:45328380:C:A (rs58446550)		A	5.5e-53	IGAP 2013: Stage 1	NG00036
downstream	19:45416291:C:T (rs59325138)		T	1.3e-52	IGAP (2013): ADGC Subset	NG00053
upstream	19:45401868:T:C (rs118170342)		C	1.7e-52	IGAP 2013: Stage 1	NG00036
upstream	19:45359706:G:A (rs12462573)		A	3.2e-52	IGAP (2013): ADGC Subset	NG00053
upstream	19:45385759:G:C (rs3745150)		C	3.4e-52	IGAP (2013): ADGC Subset	NG00053
upstream	19:45382966:C:T (rs3852860)		T	3.9e-52	IGAP 2013: Stage 1	NG00036
upstream	19:45384116:G:A (rs406315)		G	5.5e-52	IGAP 2013: Stage 1	NG00036
upstream	19:45327423:G:T (rs4803758)	N/A	T	7.8e-52	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45327309:C:T (rs10412413)		T	8.1e-52	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45398264:C:T (rs157588)		T	8.5e-52	Transethnic LOAD: All Samples	NG00056
downstream	19:45428459:C:T (rs4803772)		T	9.1e-52	IGAP (2013): ADGC Subset	NG00053
upstream	19:45397512:A:C (rs157585)		A	1.2e-51	Transethnic LOAD: All Samples	NG00056
upstream	19:45395844:G:A (rs34095326)		A	1.2e-51	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45357377:T:C (rs4803764)		T	1.3e-51	Transethnic LOAD: All Samples	NG00056
downstream	19:45429543:C:T (rs71352239)		T	2.5e-51	Transethnic LOAD: All Samples	NG00056
upstream	19:45329344:T:C (rs10402524)		T	3.9e-51	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45356464:T:A (rs73050205)		A	4.4e-51	Transethnic LOAD: All Samples	NG00056
upstream	19:45326664:C:T (rs10405693)		T	4.7e-51	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45398716:A:C (rs157590)		A	5.7e-51	IGAP (2013): ADGC Subset	NG00053
upstream	19:45404691:A:G (rs405697)		A	1.4e-50	IGAP (2013): ADGC Subset	NG00053
downstream	19:45423636:G:A (rs78959900)		A	1.7e-50	IGAP (2013): ADGC Subset	NG00053
upstream	19:45357291:G:C (rs4803763)		C	2.1e-50	Transethnic LOAD: All Samples	NG00056
upstream	19:45404691:A:G (rs405697)		A	2.3e-50	IGAP 2013: Stage 1	NG00036
upstream	19:45355721:C:G (rs2972559)		C	2.4e-50	IGAP (2013): ADGC Subset	NG00053
upstream	19:45382034:A:G (rs6859)		A	2.5e-50	ADGC 2011: Stage 1	NG00027
upstream	19:45329214:T:G (rs10402271)		T	3.8e-50	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45359586:C:T (rs56317818)		T	4.0e-50	Transethnic LOAD: All Samples	NG00056
upstream	19:45355721:C:G (rs2972559)		C	8.5e-50	Transethnic LOAD: All Samples	NG00056
upstream	19:45388588:A:T (rs200573101)	N/A	I	1.7e-49	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45388588:A:ATT (rs35951235)	N/A	I	1.7e-49	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45359706:G:A (rs12462573)		A	1.9e-49	Transethnic LOAD: All Samples	NG00056
downstream	19:45427353:C:G (rs4803770)		C	1.9e-49	IGAP (2013): ADGC Subset	NG00053
downstream	19:45421744:G:T (rs12721056)		T	8.4e-49	IGAP (2013): ADGC Subset	NG00053
upstream	19:45397952:T:C (rs116881820)		T	1.3e-48	Transethnic LOAD: All Samples	NG00056
upstream	19:45395844:G:A (rs34095326)		A	5.5e-48	ADGC Age of Onset LOAD	NG00048
downstream	19:45413576:C:T (rs75627662)		T	1.8e-47	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45337385:G:C (rs2927480)		C	2.7e-47	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45336035:T:C (rs7359852)		T	3.9e-47	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45357291:G:C (rs4803763)		C	5.0e-47	ADGC 2011: Stage 1	NG00027
in gene	19:45411941:T:C (rs429358)		T	5.5e-47	ADGC African Americans 2013	NG00039
upstream	19:45383061:G:T (rs3852861)		T	8.3e-47	IGAP 2013: Stage 1	NG00036
upstream	19:45398264:C:T (rs157588)		T	3.5e-46	IGAP (2013): ADGC Subset	NG00053
upstream	19:45397512:A:C (rs157585)		A	3.8e-46	IGAP (2013): ADGC Subset	NG00053
upstream	19:45358353:T:C (rs10410835)		T	1.3e-45	IGAP 2013: Stage 1	NG00036
upstream	19:45386634:C:T (rs147636938)		T	1.4e-45	Transethnic LOAD: All Samples	NG00056
upstream	19:45326217:T:C (rs10406338)		T	1.7e-45	Transethnic LOAD: All Samples	NG00056
upstream	19:45382717:G:A (rs406456)		G	1.8e-45	IGAP 2013: Stage 1	NG00036
upstream	19:45326664:C:T (rs10405693)		T	3.3e-45	Transethnic LOAD: All Samples	NG00056
upstream	19:45401666:A:G (rs8106922)		A	5.1e-45	ADGC 2011: Stage 1	NG00027
downstream	19:45414451:T:C (rs439401)		T	5.6e-45	ADGC 2011: Stage 1	NG00027
upstream	19:45384405:T:C (rs73052307)	N/A	T	6.0e-45	IGAP (2013): ADGC Subset	NG00053
upstream	19:45398633:G:C (rs11668327)		C	6.1e-45	IGAP (2013): ADGC Subset	NG00053
upstream	19:45331725:C:T (rs4802238)		T	7.4e-45	Transethnic LOAD: All Samples	NG00056
upstream	19:45354296:A:G (rs11666329)		A	1.4e-44	IGAP 2013: Stage 1	NG00036
upstream	19:45357003:C:G (rs35396326)		C	1.5e-44	Transethnic LOAD: All Samples	NG00056
upstream	19:45408836:T:G (rs405509)		T	3.0e-44	ADGC 2011: Stage 1	NG00027
downstream	19:45429543:C:T (rs71352239)		T	3.5e-44	IGAP (2013): ADGC Subset	NG00053
upstream	19:45396899:T:C (rs157584)		T	4.1e-44	Transethnic LOAD: All Samples	NG00056
upstream	19:45327309:C:T (rs10412413)		T	4.3e-44	Transethnic LOAD: All Samples	NG00056
upstream	19:45327423:G:T (rs4803758)	N/A	T	4.4e-44	Transethnic LOAD: All Samples	NG00056
in gene	19:45412079:C:T (rs7412)	N/A	T	5.9e-44	Transethnic LOAD: All Samples	NG00056
upstream	19:45329214:T:G (rs10402271)		T	8.7e-44	ADGC 2011: Stages 1 and 2	NG00027
upstream	19:45328367:A:T (rs58132661)		A	1.1e-43	Transethnic LOAD: All Samples	NG00056
upstream	19:45357939:A:G (rs2927468)		A	4.2e-43	IGAP (2013): ADGC Subset	NG00053
upstream	19:45329214:T:G (rs10402271)		T	4.7e-42	Transethnic LOAD: All Samples	NG00056
upstream	19:45404691:A:G (rs405697)		A	6.2e-42	Transethnic LOAD: All Samples	NG00056
upstream	19:45348522:G:T (rs12162222)		T	7.3e-42	IGAP (2013): ADGC Subset	NG00053
upstream	19:45396973:G:A (rs77301115)		A	8.2e-42	IGAP (2013): ADGC Subset	NG00053
upstream	19:45329344:T:C (rs10402524)		T	1.0e-41	Transethnic LOAD: All Samples	NG00056
upstream	19:45328380:C:A (rs58446550)		A	5.7e-41	Transethnic LOAD: All Samples	NG00056
upstream	19:45328379:T:A (rs58826447)		A	5.8e-41	Transethnic LOAD: All Samples	NG00056
upstream	19:45386467:G:GTAA (rs142042446)	N/A	I	6.9e-41	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45324138:G:A (rs28399637)		A	1.9e-40	IGAP (2013): ADGC Subset	NG00053
upstream	19:45327423:G:T (rs4803758)	N/A	T	1.9e-40	IGAP (2013): ADGC Subset	NG00053
downstream	19:45421204:C:T (rs150966173)		T	2.3e-40	IGAP 2013: Stage 1	NG00036
upstream	19:45380970:G:T (rs11668861)		T	2.9e-40	IGAP 2013: Stage 1	NG00036
downstream	19:45421650:G:A (rs140480140)		A	3.4e-40	IGAP 2013: Stage 1	NG00036
upstream	19:45348522:G:T (rs12162222)		T	3.7e-40	Transethnic LOAD: All Samples	NG00056
upstream	19:45327309:C:T (rs10412413)		T	4.2e-40	IGAP (2013): ADGC Subset	NG00053
upstream	19:45345623:G:A (rs2199575)		A	5.4e-40	Transethnic LOAD: All Samples	NG00056
upstream	19:45408564:A:T (rs449647)		T	1.5e-39	IGAP 2013: Stage 1	NG00036
upstream	19:45396899:T:C (rs157584)		T	2.0e-39	IGAP (2013): ADGC Subset	NG00053
upstream	19:45363820:T:G (rs138607350)		G	2.2e-39	IGAP 2013: Stage 1	NG00036
downstream	19:45417632:C:CCCTT (rs201225864)	N/A	I	3.8e-39	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45417638:C:CTTCG (rs11568822)	N/A	I	3.8e-39	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45417638:C:G (rs79626409)	N/A	I	3.8e-39	AD Age of Onset Survival (IGAP)	NG00058
downstream	19:45417638:C:CTTCG (rs34954997)	N/A	I	3.8e-39	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45328367:A:T (rs58132661)		A	4.7e-39	IGAP (2013): ADGC Subset	NG00053
upstream	19:45326217:T:C (rs10406338)		T	1.0e-38	IGAP (2013): ADGC Subset	NG00053
upstream	19:45336443:G:A (rs3021439)		A	1.3e-38	IGAP (2013): ADGC Subset	NG00053
upstream	19:45383061:G:T (rs3852861)		T	1.4e-38	Transethnic LOAD: All Samples	NG00056
upstream	19:45382966:C:T (rs3852860)		T	1.9e-38	Transethnic LOAD: All Samples	NG00056
upstream	19:45337504:G:C (rs11667241)		C	2.7e-38	IGAP (2013): ADGC Subset	NG00053
upstream	19:45336035:T:C (rs7359852)		T	5.9e-38	IGAP (2013): ADGC Subset	NG00053
upstream	19:45341540:A:G (rs12462274)		A	9.9e-38	Transethnic LOAD: All Samples	NG00056
upstream	19:45326217:T:C (rs10406338)		T	1.1e-37	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45337249:C:A (rs2927481)		A	1.8e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45342007:G:C (rs74579864)		C	1.8e-37	Transethnic LOAD: All Samples	NG00056
upstream	19:45399344:G:T (rs75687619)		T	1.8e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45329344:T:C (rs10402524)		T	2.0e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45398785:C:T (rs79398853)		T	2.1e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45338523:G:C (rs73048288)		C	2.4e-37	Transethnic LOAD: All Samples	NG00056
upstream	19:45397952:T:C (rs116881820)		T	2.5e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45397307:C:T (rs112849259)		T	2.7e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45341904:G:A (rs12459575)		A	5.8e-37	IGAP (2013): ADGC Subset	NG00053
upstream	19:45338523:G:C (rs73048288)		C	1.9e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45341540:A:G (rs12462274)		A	2.1e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45393516:C:T (rs117310449)		T	3.7e-36	IGAP 2013: Stage 1	NG00036
upstream	19:45342114:A:G (rs4803761)		A	3.8e-36	Transethnic LOAD: All Samples	NG00056
downstream	19:45412955:A:C (rs1081105)		A	4.6e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45342161:G:A (rs4803762)		A	4.9e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45345623:G:A (rs2199575)		A	5.1e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45341948:A:G (rs10407439)		A	5.3e-36	IGAP 2013: Stage 1	NG00036
upstream	19:45342007:G:C (rs74579864)		C	6.3e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45408836:T:G (rs405509)		T	8.4e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45400725:C:T (rs114536010)		T	8.9e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45399896:G:A (rs76366838)		A	9.3e-36	IGAP (2013): ADGC Subset	NG00053
upstream	19:45357939:A:G (rs2927468)		A	9.5e-36	Transethnic LOAD: All Samples	NG00056
upstream	19:45401868:T:C (rs118170342)		T	1.0e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45404857:T:C (rs112019714)		T	1.1e-35	IGAP (2013): ADGC Subset	NG00053
upstream	19:45403216:C:T (rs115881343)		T	1.1e-35	IGAP (2013): ADGC Subset	NG00053
upstream	19:45384405:T:C (rs73052307)	N/A	T	1.2e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45358353:T:C (rs10410835)		T	1.9e-35	IGAP (2013): ADGC Subset	NG00053
upstream	19:45380970:G:T (rs11668861)		T	1.9e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45340736:G:A (rs73048293)		A	2.8e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45337385:G:C (rs2927480)		C	3.3e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45341904:G:A (rs12459575)		A	9.3e-35	Transethnic LOAD: All Samples	NG00056
upstream	19:45394211:C:T (rs76692773)		T	1.2e-34	IGAP 2013: Stage 1	NG00036
upstream	19:45358353:T:C (rs10410835)		T	5.8e-34	Transethnic LOAD: All Samples	NG00056
upstream	19:45342114:A:G (rs4803761)		A	9.1e-34	IGAP (2013): ADGC Subset	NG00053
upstream	19:45382675:G:A (rs41290120)		A	1.4e-33	IGAP 2013: Stage 1	NG00036
upstream	19:45337385:G:C (rs2927480)		C	1.6e-33	ADGC 2011: Stage 1	NG00027
upstream	19:45326664:C:T (rs10405693)		T	1.7e-33	IGAP (2013): ADGC Subset	NG00053
upstream	19:45336035:T:C (rs7359852)		T	1.8e-33	ADGC 2011: Stage 1	NG00027
upstream	19:45336443:G:A (rs3021439)		A	2.0e-33	Transethnic LOAD: All Samples	NG00056
upstream	19:45392254:C:T (rs6857)		T	2.3e-33	Transethnic LOAD: APOE e4 Carriers	NG00056
upstream	19:45352487:A:T (rs12974942)		T	5.5e-33	IGAP 2013: Stage 1	NG00036
upstream	19:45329214:T:G (rs10402271)		T	8.7e-33	IGAP (2013): ADGC Subset	NG00053
upstream	19:45385759:G:C (rs3745150)		C	2.4e-32	ADGC 2011: Stage 1	NG00027
upstream	19:45336035:T:C (rs7359852)		T	2.6e-32	Transethnic LOAD: All Samples	NG00056
downstream	19:45418486:G:A (rs12691088)		A	3.1e-32	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45349402:T:C (rs3810143)		C	4.7e-32	IGAP 2013: Stage 1	NG00036
upstream	19:45351516:C:G (rs41289512)		C	8.5e-32	AD Age of Onset Survival (IGAP)	NG00058
upstream	19:45372867:G:A (rs387465)	N/A	A	1.1e-31	Transethnic LOAD: All Samples	NG00056
upstream	19:45347911:C:A (rs4452060)		A	1.3e-31	IGAP 2013: Stage 1	NG00036

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APOE - ENSG00000130203

apolipoprotein E

Contents

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

To add tracks, use the provided link to switch to the full genome browser view.

Gene-based Trait Associations

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the APOE gene.

APOE - ENSG00000130203

apolipoprotein E

Contents

Genomic Context The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region. To add tracks, use the provided link to switch to the full genome browser view.

Gene-based Trait Associations

Genetic Variation and Variant-based Trait Associations (GWAS) Variants contained within the APOE gene.

Genomic Context

The genome browser snapshot is fully interactive. Mouse over track elements for more information. Click and drag to move tracks. Click and drag on top positional guide to zoom to a sub-region.

To add tracks, use the provided link to switch to the full genome browser view.

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the APOE gene.