Genomic Context

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Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

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Accession Population N SNPs p-value Sign. Level rho CMAF CMAC Covariates Variant Filter Caveats
NG00065 European 18 3.3e-03 N/A 0 4.8e-03 100.2 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Meta 24 6.9e-03 N/A 0 0.010 224.3 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 15 N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 20 N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 20 N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs and sequencing center CADD > 20 N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 15 N/A
NG00065 European 27 9.4e-03 N/A 0 3.4e-03 71.8 PCs and sequencing center CADD > 15 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 20 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 15 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 20 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs and sequencing center CADD > 20 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs and sequencing center CADD > 15 N/A
NG00065 Meta 33 9.4e-03 N/A 0 9.0e-03 194.9 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 15 N/A
NG00065 European 18 0.103 N/A 0 4.8e-03 100.2 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 18 0.120 N/A 1 4.8e-03 100.2 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Meta 24 0.147 N/A 0 0.010 224.3 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Meta 24 0.201 N/A 0 0.010 224.3 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.353 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 Caribbean Hispanic 1 0.353 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 Caribbean Hispanic 7 0.360 N/A 1 0.015 11.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 7 0.366 N/A 1 0.015 11.8 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.373 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 Caribbean Hispanic 1 0.373 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 Caribbean Hispanic 7 0.373 N/A 1 0.015 11.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.377 N/A 0 1.3e-03 1.0 PCs and sequencing center LOF
NG00065 Caribbean Hispanic 1 0.377 N/A 0 1.3e-03 1.0 PCs and sequencing center VEP HIGH
NG00065 European 3 0.406 N/A 0 1.9e-04 4.1 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 European 3 0.408 N/A 0 1.9e-04 4.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 European 3 0.409 N/A 0 1.9e-04 4.1 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 European 3 0.410 N/A 0 1.9e-04 4.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 European 3 0.420 N/A 0 1.9e-04 4.1 PCs and sequencing center VEP HIGH
NG00065 European 3 0.420 N/A 0 1.9e-04 4.0 PCs and sequencing center LOF
NG00065 Meta 4 0.445 N/A 1 2.3e-04 5.1 PCs and sequencing center VEP HIGH
NG00065 Meta 4 0.471 N/A 0 2.3e-04 5.1 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 Meta 4 0.487 N/A 0 2.3e-04 5.1 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs and sequencing center CADD > 20 N/A
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs and sequencing center CADD > 15 N/A
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 20 N/A
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes CADD > 15 N/A
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 15 N/A
NG00065 Caribbean Hispanic 7 0.652 N/A 1 0.014 10.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) CADD > 20 N/A

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the APOE gene.

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The APOE gene contains 461 variants records (corresponding to 418 unique genomic positions).

The following variants, contained within ±100kb of APOE, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of APOE that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

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Login in to select variants and add them to your basket.

Relative Position Variant ADSP? Allele p-Value Track Accession
downstream A 0.000 ADGC 2011: Stages 1 and 2 NG00027
upstream T 2.5e-575 IGAP 2013: Stage 1 NG00036
in gene T 1.4e-546 Transethnic LOAD: All Samples NG00056
in gene C 6.7e-536 IGAP 2013: Stage 1 NG00036
in gene A 9.9e-523 IGAP 2013: Stage 1 NG00036
downstream A 1.2e-522 IGAP 2013: Stage 1 NG00036
downstream T 1.8e-520 IGAP 2013: Stage 1 NG00036
upstream T 2.0e-486 IGAP 2013: Stage 1 NG00036
downstream G 7.8e-482 IGAP 2013: Stage 1 NG00036
upstream G 8.5e-475 IGAP 2013: Stage 1 NG00036
upstream C 8.9e-469 IGAP 2013: Stage 1 NG00036
upstream G 6.4e-466 IGAP 2013: Stage 1 NG00036
upstream T 2.6e-464 IGAP 2013: Stage 1 NG00036
upstream G 5.1e-464 IGAP 2013: Stage 1 NG00036
upstream C 2.5e-462 IGAP 2013: Stage 1 NG00036
downstream A 2.0e-454 IGAP 2013: Stage 1 NG00036
upstream G 6.5e-442 IGAP 2013: Stage 1 NG00036
upstream A 4.9e-440 IGAP 2013: Stage 1 NG00036
downstream C 3.8e-439 Transethnic LOAD: All Samples NG00056
in gene A 5.3e-435 Transethnic LOAD: All Samples NG00056
upstream G 2.7e-434 IGAP 2013: Stage 1 NG00036
upstream G 3.2e-434 IGAP 2013: Stage 1 NG00036
upstream T 9.7e-434 IGAP 2013: Stage 1 NG00036
upstream A 5.4e-432 IGAP 2013: Stage 1 NG00036
downstream A 2.5e-427 IGAP 2013: Stage 1 NG00036
downstream A 1.1e-421 IGAP 2013: Stage 1 NG00036
upstream T 4.4e-419 Transethnic LOAD: All Samples NG00056
downstream A 6.3e-411 Transethnic LOAD: All Samples NG00056
downstream A 2.2e-410 Transethnic LOAD: All Samples NG00056
downstream A 7.0e-405 IGAP 2013: Stage 1 NG00036
downstream G 1.7e-396 IGAP 2013: Stage 1 NG00036
downstream C 8.6e-390 IGAP 2013: Stage 1 NG00036
downstream A 1.0e-385 Transethnic LOAD: All Samples NG00056
downstream T 2.1e-373 IGAP 2013: Stage 1 NG00036
downstream A 3.5e-359 Transethnic LOAD: All Samples NG00056
in gene T 6.6e-357 IGAP (2013): ADGC Subset NG00053
upstream T 7.5e-357 IGAP (2013): ADGC Subset NG00053
upstream A 3.2e-354 IGAP 2013: Stage 1 NG00036
downstream T 6.3e-353 Transethnic LOAD: All Samples NG00056
downstream A 3.5e-352 Transethnic LOAD: All Samples NG00056
downstream A 6.1e-352 Transethnic LOAD: All Samples NG00056
upstream C 9.0e-350 Transethnic LOAD: All Samples NG00056
upstream A 1.2e-349 Transethnic LOAD: All Samples NG00056
upstream A 7.7e-349 Transethnic LOAD: All Samples NG00056
upstream T 4.4e-344 Transethnic LOAD: All Samples NG00056
upstream A 1.2e-342 IGAP 2013: Stage 1 NG00036
upstream A 1.2e-339 Transethnic LOAD: All Samples NG00056
upstream C 2.6e-336 Transethnic LOAD: All Samples NG00056
upstream T 2.5e-335 Transethnic LOAD: All Samples NG00056
upstream N/A T 3.0e-333 Transethnic LOAD: All Samples NG00056
downstream C 7.6e-333 IGAP (2013): ADGC Subset NG00053
upstream T 1.4e-332 Transethnic LOAD: All Samples NG00056
upstream T 9.6e-331 Transethnic LOAD: All Samples NG00056
upstream T 1.6e-327 Transethnic LOAD: All Samples NG00056
downstream T 2.8e-326 IGAP 2013: Stage 1 NG00036
downstream A 4.3e-326 IGAP (2013): ADGC Subset NG00053
upstream A 3.1e-317 Transethnic LOAD: All Samples NG00056
in gene A 1.4e-313 IGAP (2013): ADGC Subset NG00053
downstream A 3.4e-311 IGAP (2013): ADGC Subset NG00053
downstream T 1.2e-310 IGAP (2013): ADGC Subset NG00053
downstream A 2.2e-309 Transethnic LOAD: All Samples NG00056
downstream T 1.5e-307 Transethnic LOAD: All Samples NG00056
upstream T 2.8e-300 IGAP (2013): ADGC Subset NG00053
upstream A 7.1e-300 Transethnic LOAD: All Samples NG00056
upstream T 1.2e-298 Transethnic LOAD: All Samples NG00056
upstream A 8.8e-297 Transethnic LOAD: All Samples NG00056
upstream T 1.8e-294 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-291 Transethnic LOAD: All Samples NG00056
downstream A 8.0e-291 IGAP (2013): ADGC Subset NG00053
downstream A 1.8e-290 IGAP (2013): ADGC Subset NG00053
upstream T 6.4e-290 IGAP (2013): ADGC Subset NG00053
upstream C 4.5e-288 IGAP (2013): ADGC Subset NG00053
upstream T 1.7e-286 IGAP (2013): ADGC Subset NG00053
downstream A 4.9e-286 IGAP (2013): ADGC Subset NG00053
upstream A 1.5e-285 IGAP (2013): ADGC Subset NG00053
upstream T 3.3e-285 IGAP (2013): ADGC Subset NG00053
upstream A 2.0e-273 IGAP (2013): ADGC Subset NG00053
upstream A 1.6e-270 IGAP (2013): ADGC Subset NG00053
upstream A 2.9e-268 IGAP (2013): ADGC Subset NG00053
downstream A 1.1e-266 ADGC 2011: Stage 1 NG00027
upstream C 1.3e-263 IGAP (2013): ADGC Subset NG00053
upstream A 3.0e-263 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-260 Transethnic LOAD: All Samples NG00056
upstream T 3.0e-254 IGAP (2013): ADGC Subset NG00053
downstream A 5.7e-243 IGAP (2013): ADGC Subset NG00053
downstream T 2.8e-239 IGAP (2013): ADGC Subset NG00053
downstream T 2.1e-232 IGAP (2013): ADGC Subset NG00053
upstream A 3.1e-226 IGAP (2013): ADGC Subset NG00053
downstream N/A A 3.5e-224 Transethnic LOAD: All Samples NG00056
upstream A 8.2e-216 Transethnic LOAD: All Samples NG00056
upstream A 6.4e-212 IGAP (2013): ADGC Subset NG00053
downstream T 1.7e-210 Transethnic LOAD: All Samples NG00056
upstream T 2.2e-206 ADGC 2011: Stage 1 NG00027
downstream T 1.4e-204 IGAP (2013): ADGC Subset NG00053
upstream A 6.2e-184 ADGC 2011: Stage 1 NG00027
upstream T 8.2e-178 ADGC 2011: Stage 1 NG00027
upstream G 2.2e-167 IGAP 2013: Stage 1 NG00036
downstream A 1.7e-134 IGAP 2013: Stage 1 NG00036
upstream A 1.9e-133 Transethnic LOAD: All Samples NG00056
upstream A 2.2e-132 Transethnic LOAD: All Samples NG00056
upstream T 4.7e-132 Transethnic LOAD: All Samples NG00056
upstream T 9.5e-132 Transethnic LOAD: All Samples NG00056
upstream A 1.1e-128 ADGC 2011: Stage 1 NG00027
upstream G 1.7e-128 IGAP 2013: Stage 1 NG00036
upstream T 3.6e-128 Transethnic LOAD: All Samples NG00056
upstream C 2.3e-127 IGAP 2013: Stage 1 NG00036
upstream C 1.0e-126 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-126 IGAP 2013: Stage 1 NG00036
upstream A 3.0e-125 Transethnic LOAD: All Samples NG00056
upstream A 3.3e-125 IGAP 2013: Stage 1 NG00036
upstream T 6.2e-125 IGAP 2013: Stage 1 NG00036
downstream A 3.8e-121 ADGC 2011: Stage 2 NG00027
downstream A 8.1e-116 IGAP (2013): ADGC Subset NG00053
upstream T 3.5e-115 IGAP 2013: Stage 1 NG00036
upstream G 2.0e-114 IGAP 2013: Stage 1 NG00036
upstream T 4.8e-114 IGAP 2013: Stage 1 NG00036
upstream C 3.2e-112 IGAP 2013: Stage 1 NG00036
downstream A 9.0e-109 IGAP 2013: Stage 1 NG00036
upstream A 1.5e-108 IGAP 2013: Stage 1 NG00036
in gene A 5.1e-104 IGAP 2013: Stage 1 NG00036
upstream C 1.9e-103 IGAP (2013): ADGC Subset NG00053
upstream G 1.2e-101 IGAP 2013: Stage 1 NG00036
in gene A 1.4e-101 Transethnic LOAD: All Samples NG00056
downstream A 3.8e-101 IGAP 2013: Stage 1 NG00036
downstream A 4.8e-100 Transethnic LOAD: All Samples NG00056
upstream T 2.3e-99 Transethnic LOAD: All Samples NG00056
upstream C 8.3e-99 Transethnic LOAD: All Samples NG00056
upstream A 2.0e-98 IGAP (2013): ADGC Subset NG00053
upstream T 9.1e-98 Transethnic LOAD: All Samples NG00056
upstream G 5.4e-97 IGAP 2013: Stage 1 NG00036
upstream A 8.5e-97 Transethnic LOAD: All Samples NG00056
upstream T 3.3e-96 ADGC Age of Onset LOAD NG00048
upstream A 3.3e-96 IGAP 2013: Stage 1 NG00036
upstream A 2.0e-95 Transethnic LOAD: All Samples NG00056
upstream T 1.2e-94 Transethnic LOAD: All Samples NG00056
upstream T 1.1e-93 ADGC Age of Onset LOAD NG00048
upstream T 3.5e-93 ADGC Age of Onset LOAD NG00048
downstream A 1.3e-92 Transethnic LOAD: All Samples NG00056
downstream T 6.9e-89 IGAP 2013: Stage 1 NG00036
in gene T 8.1e-89 ADGC Age of Onset LOAD NG00048
upstream C 9.9e-89 IGAP 2013: Stage 1 NG00036
downstream T 1.3e-88 IGAP 2013: Stage 1 NG00036
upstream C 4.2e-87 IGAP 2013: Stage 1 NG00036
upstream A 5.4e-87 IGAP (2013): ADGC Subset NG00053
upstream G 1.4e-86 IGAP 2013: Stage 1 NG00036
downstream T 3.0e-86 Transethnic LOAD: All Samples NG00056
upstream T 1.8e-85 IGAP 2013: Stage 1 NG00036
upstream C 2.8e-85 IGAP 2013: Stage 1 NG00036
downstream A 2.9e-85 Transethnic LOAD: All Samples NG00056
upstream A 2.9e-85 IGAP 2013: Stage 1 NG00036
downstream A 3.9e-85 IGAP 2013: Stage 1 NG00036
downstream T 9.0e-85 Transethnic LOAD: All Samples NG00056
downstream A 2.3e-84 IGAP (2013): ADGC Subset NG00053
upstream A 3.4e-84 ADGC Age of Onset LOAD NG00048
downstream C 5.0e-84 ADGC Age of Onset LOAD NG00048
downstream G 1.1e-83 IGAP 2013: Stage 1 NG00036
downstream A 1.1e-82 IGAP 2013: Stage 1 NG00036
downstream T 1.2e-82 IGAP 2013: Stage 1 NG00036
upstream A 1.3e-82 IGAP (2013): ADGC Subset NG00053
upstream G 3.4e-82 IGAP 2013: Stage 1 NG00036
downstream T 4.3e-82 IGAP 2013: Stage 1 NG00036
downstream A 5.1e-82 ADGC Age of Onset LOAD NG00048
upstream T 1.1e-81 IGAP (2013): ADGC Subset NG00053
upstream T 3.1e-81 IGAP (2013): ADGC Subset NG00053
upstream T 4.6e-81 ADGC Age of Onset LOAD NG00048
upstream A 6.5e-81 IGAP (2013): ADGC Subset NG00053
upstream A 7.8e-81 IGAP 2013: Stage 1 NG00036
upstream C 1.1e-80 IGAP 2013: Stage 1 NG00036
upstream T 1.6e-80 IGAP (2013): ADGC Subset NG00053
downstream T 2.3e-80 Transethnic LOAD: All Samples NG00056
downstream C 1.1e-79 Transethnic LOAD: All Samples NG00056
downstream A 2.8e-79 Transethnic LOAD: All Samples NG00056
downstream T 3.5e-79 IGAP 2013: Stage 1 NG00036
upstream A 4.9e-79 IGAP (2013): ADGC Subset NG00053
upstream A 8.8e-79 ADGC Age of Onset LOAD NG00048
downstream T 1.9e-77 Transethnic LOAD: All Samples NG00056
downstream A 1.2e-76 Transethnic LOAD: All Samples NG00056
upstream A 2.1e-76 IGAP 2013: Stage 1 NG00036
upstream C 2.8e-76 IGAP 2013: Stage 1 NG00036
upstream T 2.8e-76 IGAP 2013: Stage 1 NG00036
in gene A 2.4e-75 ADGC Age of Onset LOAD NG00048
downstream T 1.5e-74 ADGC Age of Onset LOAD NG00048
downstream C 2.4e-74 Transethnic LOAD: All Samples NG00056
upstream A 5.8e-74 ADGC 2011: Stages 1 and 2 NG00027
upstream G 4.4e-73 IGAP 2013: Stage 1 NG00036
upstream A 4.5e-73 Transethnic LOAD: All Samples NG00056
downstream A 4.5e-73 ADGC Age of Onset LOAD NG00048
downstream A 1.1e-72 ADGC Age of Onset LOAD NG00048
upstream T 3.9e-72 IGAP 2013: Stage 1 NG00036
downstream T 7.8e-72 Transethnic LOAD: All Samples NG00056
downstream T 9.0e-72 Transethnic LOAD: All Samples NG00056
upstream A 3.2e-71 Transethnic LOAD: All Samples NG00056
downstream A 5.4e-71 IGAP (2013): ADGC Subset NG00053
upstream C 9.5e-71 ADGC Age of Onset LOAD NG00048
upstream T 4.3e-70 ADGC Age of Onset LOAD NG00048
in gene C 9.5e-70 Transethnic LOAD: All Samples NG00056
upstream T 1.1e-69 ADGC Age of Onset LOAD NG00048
downstream T 1.7e-69 IGAP (2013): ADGC Subset NG00053
upstream T 3.0e-69 IGAP 2013: Stage 1 NG00036
downstream A 3.4e-69 ADGC Age of Onset LOAD NG00048
upstream C 3.5e-69 Transethnic LOAD: All Samples NG00056
upstream T 3.8e-69 IGAP 2013: Stage 1 NG00036
upstream C 4.7e-69 IGAP 2013: Stage 1 NG00036
upstream A 4.7e-69 IGAP 2013: Stage 1 NG00036
upstream T 5.4e-69 IGAP 2013: Stage 1 NG00036
downstream A 6.7e-69 ADGC Age of Onset LOAD NG00048
upstream T 7.5e-69 IGAP (2013): ADGC Subset NG00053
upstream T 2.4e-68 IGAP (2013): ADGC Subset NG00053
downstream T 6.3e-68 IGAP 2013: Stage 1 NG00036
upstream A 8.0e-68 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.2e-67 IGAP 2013: Stage 1 NG00036
downstream A 1.6e-67 IGAP (2013): ADGC Subset NG00053
in gene C 1.6e-67 IGAP (2013): ADGC Subset NG00053
upstream T 1.8e-67 IGAP 2013: Stage 1 NG00036
upstream A 2.0e-67 IGAP 2013: Stage 1 NG00036
in gene C 2.3e-67 IGAP 2013: Stage 1 NG00036
upstream A 2.8e-67 ADGC Age of Onset LOAD NG00048
upstream C 2.9e-67 ADGC 2011: Stages 1 and 2 NG00027
upstream T 3.3e-67 IGAP 2013: Stage 1 NG00036
downstream A 3.7e-67 ADGC Age of Onset LOAD NG00048
upstream C 4.6e-67 IGAP (2013): ADGC Subset NG00053
upstream T 4.8e-67 IGAP 2013: Stage 1 NG00036
upstream N/A C 4.9e-67 IGAP 2013: Stage 1 NG00036
upstream C 5.5e-67 IGAP 2013: Stage 1 NG00036
upstream C 1.2e-66 IGAP 2013: Stage 1 NG00036
upstream C 1.5e-65 IGAP 2013: Stage 1 NG00036
upstream A 1.8e-65 IGAP 2013: Stage 1 NG00036
downstream C 2.0e-65 IGAP 2013: Stage 1 NG00036
upstream A 4.1e-65 IGAP 2013: Stage 1 NG00036
downstream A 4.1e-65 IGAP 2013: Stage 1 NG00036
upstream C 4.4e-65 IGAP 2013: Stage 1 NG00036
upstream C 1.4e-64 IGAP 2013: Stage 1 NG00036
upstream T 2.6e-64 IGAP 2013: Stage 1 NG00036
upstream C 9.3e-64 IGAP 2013: Stage 1 NG00036
downstream T 1.0e-63 ADGC Age of Onset LOAD NG00048
upstream A 1.6e-63 Transethnic LOAD: All Samples NG00056
upstream A 2.2e-63 IGAP 2013: Stage 1 NG00036
upstream A 2.6e-63 IGAP 2013: Stage 1 NG00036
upstream C 1.1e-62 IGAP 2013: Stage 1 NG00036
downstream T 1.6e-62 ADGC Age of Onset LOAD NG00048
upstream C 2.7e-62 IGAP 2013: Stage 1 NG00036
upstream A 2.8e-62 IGAP 2013: Stage 1 NG00036
downstream T 4.6e-62 IGAP 2013: Stage 1 NG00036
upstream T 5.2e-62 ADGC Age of Onset LOAD NG00048
downstream T 2.5e-61 IGAP (2013): ADGC Subset NG00053
upstream G 7.7e-61 IGAP 2013: Stage 1 NG00036
upstream T 1.2e-60 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-60 ADGC Age of Onset LOAD NG00048
downstream T 4.2e-60 IGAP (2013): ADGC Subset NG00053
upstream G 6.2e-60 IGAP 2013: Stage 1 NG00036
in gene A 2.4e-59 IGAP (2013): ADGC Subset NG00053
upstream G 4.8e-59 IGAP 2013: Stage 1 NG00036
upstream A 6.2e-59 ADGC Age of Onset LOAD NG00048
upstream A 1.7e-58 IGAP 2013: Stage 1 NG00036
upstream C 4.8e-58 IGAP 2013: Stage 1 NG00036
upstream A 8.6e-58 IGAP (2013): ADGC Subset NG00053
upstream T 1.1e-57 Transethnic LOAD: All Samples NG00056
upstream A 4.7e-57 Transethnic LOAD: All Samples NG00056
upstream A 6.2e-57 IGAP (2013): ADGC Subset NG00053
downstream A 1.1e-56 Transethnic LOAD: All Samples NG00056
downstream A 1.7e-56 Transethnic LOAD: All Samples NG00056
upstream T 2.8e-56 Transethnic LOAD: All Samples NG00056
downstream T 3.1e-56 ADGC Age of Onset LOAD NG00048
upstream A 7.3e-56 ADGC Age of Onset LOAD NG00048
upstream C 1.1e-55 Transethnic LOAD: All Samples NG00056
upstream T 1.5e-55 Transethnic LOAD: All Samples NG00056
upstream T 3.3e-55 Transethnic LOAD: All Samples NG00056
upstream A 8.5e-55 Transethnic LOAD: All Samples NG00056
upstream C 9.0e-55 IGAP (2013): ADGC Subset NG00053
downstream A 9.2e-55 IGAP (2013): ADGC Subset NG00053
downstream N/A A 1.2e-54 Transethnic LOAD: All Samples NG00056
upstream T 1.3e-54 Transethnic LOAD: All Samples NG00056
upstream A 1.4e-54 ADGC 2011: Stage 1 NG00027
upstream T 3.2e-54 IGAP (2013): ADGC Subset NG00053
upstream T 3.9e-54 IGAP (2013): ADGC Subset NG00053
upstream C 4.8e-54 IGAP (2013): ADGC Subset NG00053
upstream A 2.0e-53 ADGC Age of Onset LOAD NG00048
upstream A 3.1e-53 Transethnic LOAD: All Samples NG00056
upstream T 3.2e-53 Transethnic LOAD: All Samples NG00056
upstream A 5.2e-53 IGAP (2013): ADGC Subset NG00053
upstream A 5.4e-53 IGAP 2013: Stage 1 NG00036
upstream A 5.5e-53 IGAP 2013: Stage 1 NG00036
downstream T 1.3e-52 IGAP (2013): ADGC Subset NG00053
upstream C 1.7e-52 IGAP 2013: Stage 1 NG00036
upstream A 3.2e-52 IGAP (2013): ADGC Subset NG00053
upstream C 3.4e-52 IGAP (2013): ADGC Subset NG00053
upstream T 3.9e-52 IGAP 2013: Stage 1 NG00036
upstream G 5.5e-52 IGAP 2013: Stage 1 NG00036
upstream T 8.5e-52 Transethnic LOAD: All Samples NG00056
downstream T 9.1e-52 IGAP (2013): ADGC Subset NG00053
upstream A 1.2e-51 Transethnic LOAD: All Samples NG00056
upstream T 1.3e-51 Transethnic LOAD: All Samples NG00056
downstream T 2.5e-51 Transethnic LOAD: All Samples NG00056
upstream A 4.4e-51 Transethnic LOAD: All Samples NG00056
upstream A 5.7e-51 IGAP (2013): ADGC Subset NG00053
upstream A 1.4e-50 IGAP (2013): ADGC Subset NG00053
downstream A 1.7e-50 IGAP (2013): ADGC Subset NG00053
upstream C 2.1e-50 Transethnic LOAD: All Samples NG00056
upstream A 2.3e-50 IGAP 2013: Stage 1 NG00036
upstream C 2.4e-50 IGAP (2013): ADGC Subset NG00053
upstream A 2.5e-50 ADGC 2011: Stage 1 NG00027
upstream T 4.0e-50 Transethnic LOAD: All Samples NG00056
upstream C 8.5e-50 Transethnic LOAD: All Samples NG00056
upstream A 1.9e-49 Transethnic LOAD: All Samples NG00056
downstream C 1.9e-49 IGAP (2013): ADGC Subset NG00053
downstream T 8.4e-49 IGAP (2013): ADGC Subset NG00053
upstream T 1.3e-48 Transethnic LOAD: All Samples NG00056
upstream A 5.5e-48 ADGC Age of Onset LOAD NG00048
upstream C 2.7e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream T 3.9e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream C 5.0e-47 ADGC 2011: Stage 1 NG00027
in gene T 5.5e-47 ADGC African Americans 2013 NG00039
upstream T 8.3e-47 IGAP 2013: Stage 1 NG00036
upstream T 3.5e-46 IGAP (2013): ADGC Subset NG00053
upstream A 3.8e-46 IGAP (2013): ADGC Subset NG00053
upstream T 1.3e-45 IGAP 2013: Stage 1 NG00036
upstream T 1.4e-45 Transethnic LOAD: All Samples NG00056
upstream T 1.7e-45 Transethnic LOAD: All Samples NG00056
upstream G 1.8e-45 IGAP 2013: Stage 1 NG00036
upstream T 3.3e-45 Transethnic LOAD: All Samples NG00056
upstream A 5.1e-45 ADGC 2011: Stage 1 NG00027
downstream T 5.6e-45 ADGC 2011: Stage 1 NG00027
upstream N/A T 6.0e-45 IGAP (2013): ADGC Subset NG00053
upstream C 6.1e-45 IGAP (2013): ADGC Subset NG00053
upstream T 7.4e-45 Transethnic LOAD: All Samples NG00056
upstream A 1.4e-44 IGAP 2013: Stage 1 NG00036
upstream C 1.5e-44 Transethnic LOAD: All Samples NG00056
upstream T 3.0e-44 ADGC 2011: Stage 1 NG00027
downstream T 3.5e-44 IGAP (2013): ADGC Subset NG00053
upstream T 4.1e-44 Transethnic LOAD: All Samples NG00056
upstream T 4.3e-44 Transethnic LOAD: All Samples NG00056
upstream N/A T 4.4e-44 Transethnic LOAD: All Samples NG00056
in gene N/A T 5.9e-44 Transethnic LOAD: All Samples NG00056
upstream T 8.7e-44 ADGC 2011: Stages 1 and 2 NG00027
upstream A 1.1e-43 Transethnic LOAD: All Samples NG00056
upstream A 4.2e-43 IGAP (2013): ADGC Subset NG00053
upstream T 4.7e-42 Transethnic LOAD: All Samples NG00056
upstream A 6.2e-42 Transethnic LOAD: All Samples NG00056
upstream T 7.3e-42 IGAP (2013): ADGC Subset NG00053
upstream A 8.2e-42 IGAP (2013): ADGC Subset NG00053
upstream T 1.0e-41 Transethnic LOAD: All Samples NG00056
upstream A 5.7e-41 Transethnic LOAD: All Samples NG00056
upstream A 5.8e-41 Transethnic LOAD: All Samples NG00056
upstream A 1.9e-40 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.9e-40 IGAP (2013): ADGC Subset NG00053
downstream T 2.3e-40 IGAP 2013: Stage 1 NG00036
upstream T 2.9e-40 IGAP 2013: Stage 1 NG00036
downstream A 3.4e-40 IGAP 2013: Stage 1 NG00036
upstream T 3.7e-40 Transethnic LOAD: All Samples NG00056
upstream T 4.2e-40 IGAP (2013): ADGC Subset NG00053
upstream A 5.4e-40 Transethnic LOAD: All Samples NG00056
upstream T 1.5e-39 IGAP 2013: Stage 1 NG00036
upstream T 2.0e-39 IGAP (2013): ADGC Subset NG00053
upstream G 2.2e-39 IGAP 2013: Stage 1 NG00036
upstream A 4.7e-39 IGAP (2013): ADGC Subset NG00053
upstream T 1.0e-38 IGAP (2013): ADGC Subset NG00053
upstream A 1.3e-38 IGAP (2013): ADGC Subset NG00053
upstream T 1.4e-38 Transethnic LOAD: All Samples NG00056
upstream T 1.9e-38 Transethnic LOAD: All Samples NG00056
upstream C 2.7e-38 IGAP (2013): ADGC Subset NG00053
upstream T 5.9e-38 IGAP (2013): ADGC Subset NG00053
upstream A 9.9e-38 Transethnic LOAD: All Samples NG00056
upstream A 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream C 1.8e-37 Transethnic LOAD: All Samples NG00056
upstream T 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream T 2.0e-37 IGAP (2013): ADGC Subset NG00053
upstream T 2.1e-37 IGAP (2013): ADGC Subset NG00053
upstream C 2.4e-37 Transethnic LOAD: All Samples NG00056
upstream T 2.5e-37 IGAP (2013): ADGC Subset NG00053
upstream T 2.7e-37 IGAP (2013): ADGC Subset NG00053
upstream A 5.8e-37 IGAP (2013): ADGC Subset NG00053
upstream C 1.9e-36 IGAP (2013): ADGC Subset NG00053
upstream A 2.1e-36 IGAP (2013): ADGC Subset NG00053
upstream T 3.7e-36 IGAP 2013: Stage 1 NG00036
upstream A 3.8e-36 Transethnic LOAD: All Samples NG00056
downstream A 4.6e-36 IGAP (2013): ADGC Subset NG00053
upstream A 4.9e-36 IGAP (2013): ADGC Subset NG00053
upstream A 5.1e-36 IGAP (2013): ADGC Subset NG00053
upstream A 5.3e-36 IGAP 2013: Stage 1 NG00036
upstream C 6.3e-36 IGAP (2013): ADGC Subset NG00053
upstream T 8.4e-36 IGAP (2013): ADGC Subset NG00053
upstream T 8.9e-36 IGAP (2013): ADGC Subset NG00053
upstream A 9.3e-36 IGAP (2013): ADGC Subset NG00053
upstream A 9.5e-36 Transethnic LOAD: All Samples NG00056
upstream T 1.0e-35 Transethnic LOAD: All Samples NG00056
upstream T 1.1e-35 IGAP (2013): ADGC Subset NG00053
upstream T 1.1e-35 IGAP (2013): ADGC Subset NG00053
upstream N/A T 1.2e-35 Transethnic LOAD: All Samples NG00056
upstream T 1.9e-35 IGAP (2013): ADGC Subset NG00053
upstream T 1.9e-35 Transethnic LOAD: All Samples NG00056
upstream A 2.8e-35 Transethnic LOAD: All Samples NG00056
upstream C 3.3e-35 Transethnic LOAD: All Samples NG00056
upstream A 9.3e-35 Transethnic LOAD: All Samples NG00056
upstream T 1.2e-34 IGAP 2013: Stage 1 NG00036
upstream T 5.8e-34 Transethnic LOAD: All Samples NG00056
upstream A 9.1e-34 IGAP (2013): ADGC Subset NG00053
upstream A 1.4e-33 IGAP 2013: Stage 1 NG00036
upstream C 1.6e-33 ADGC 2011: Stage 1 NG00027
upstream T 1.7e-33 IGAP (2013): ADGC Subset NG00053
upstream T 1.8e-33 ADGC 2011: Stage 1 NG00027
upstream A 2.0e-33 Transethnic LOAD: All Samples NG00056
upstream T 2.3e-33 Transethnic LOAD: APOE e4 Carriers NG00056
upstream T 5.5e-33 IGAP 2013: Stage 1 NG00036
upstream T 8.7e-33 IGAP (2013): ADGC Subset NG00053
upstream C 2.4e-32 ADGC 2011: Stage 1 NG00027
upstream T 2.6e-32 Transethnic LOAD: All Samples NG00056
upstream C 4.7e-32 IGAP 2013: Stage 1 NG00036
upstream N/A A 1.1e-31 Transethnic LOAD: All Samples NG00056
upstream A 1.3e-31 IGAP 2013: Stage 1 NG00036
upstream A 2.6e-31 IGAP (2013): ADGC Subset NG00053
upstream T 9.3e-31 IGAP 2013: Stage 1 NG00036
upstream C 9.7e-31 Transethnic LOAD: All Samples NG00056
upstream A 1.1e-30 Transethnic LOAD: All Samples NG00056
upstream A 1.3e-30 IGAP 2013: Stage 1 NG00036
upstream A 1.4e-30 ADGC Age of Onset LOAD NG00048
upstream T 1.5e-30 IGAP 2013: Stage 1 NG00036
upstream G 1.7e-30 IGAP 2013: Stage 1 NG00036
downstream C 1.8e-30 IGAP 2013: Stage 1 NG00036
upstream T 2.3e-30 IGAP 2013: Stage 1 NG00036
upstream T 2.5e-30 IGAP (2013): ADGC Subset NG00053
upstream C 2.9e-30 IGAP 2013: Stage 1 NG00036
upstream A 3.4e-30 IGAP (2013): ADGC Subset NG00053
upstream T 4.2e-30 ADGC 2011: Stage 1 NG00027
in gene A 4.6e-30 Transethnic LOAD: APOE e4 Carriers NG00056
downstream A 5.1e-30 Transethnic LOAD: All Samples NG00056
upstream A 5.9e-30 IGAP (2013): ADGC Subset NG00053
upstream A 5.9e-30 IGAP (2013): ADGC Subset NG00053
downstream A 6.1e-30 ADGC Age of Onset LOAD NG00048
upstream A 1.2e-29 IGAP 2013: Stage 1 NG00036
downstream T 1.3e-29 Transethnic LOAD: All Samples, adjusted for APOE e4 NG00056
downstream A 3.0e-29 IGAP (2013): ADGC Subset NG00053
downstream T 3.0e-29 IGAP (2013): ADGC Subset NG00053
upstream T 4.5e-29 IGAP 2013: Stage 1 NG00036
upstream C 8.5e-29 Transethnic LOAD: All Samples NG00056
upstream G 1.1e-28 IGAP 2013: Stage 1 NG00036
upstream G 1.5e-28 IGAP 2013: Stage 1 NG00036
upstream T 1.9e-28 ADGC 2011: Stages 1 and 2 NG00027
upstream A 3.0e-28 Transethnic LOAD: APOE e4 Carriers NG00056
upstream C 4.6e-28 IGAP 2013: Stage 1 NG00036
upstream T 5.0e-28 Transethnic LOAD: APOE e4 Carriers NG00056
upstream A 7.5e-28 ADGC 2011: Stage 1 NG00027
upstream A 7.7e-28 IGAP (2013): ADGC Subset NG00053
upstream G 9.1e-28 IGAP 2013: Stage 1 NG00036
upstream T 1.3e-27 Transethnic LOAD: APOE e4 Carriers NG00056
upstream A 3.0e-27 ADGC African Americans 2013 NG00039
upstream T 4.2e-27 Transethnic LOAD: APOE e4 Carriers NG00056
upstream