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APOE - ENSG00000130203

apolipoprotein E

Location: chr19:45,409,011-45,412,650

Gene Type: protein coding

More information
NCBI Gene
348
HUGO
HGNC:613
Ensembl
ENSG00000130203
VEGA
OTTHUMG00000128901
OMIM
107741
UniProtKB
P02649

Genomic Context

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Gene-based Trait Associations

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ADSP WES: Alzheimer's Disease ADSP

Results from gene-level rare and functional variant aggregation tests for association to AD supported by significane of p < 0.5 / #genes.

Individual score test statistics for rare, predicted functional, and loss of function variants colocated with the gene were aggregated to compute gene level p-values.

See NIAGADS Accession NG00065 for more information.

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Accession Population N SNPs p-value Sign. Level rho CMAF CMAC Covariates Variant Filter Caveats
NG00065 European 18 3.3e-03 N/A 0 4.8e-03 100.2 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Meta 24 6.9e-03 N/A 0 0.010 224.3 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 European 18 0.103 N/A 0 4.8e-03 100.2 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 European 18 0.120 N/A 1 4.8e-03 100.2 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Meta 24 0.147 N/A 0 0.010 224.3 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Meta 24 0.201 N/A 0 0.010 224.3 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.353 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 Caribbean Hispanic 1 0.353 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 Caribbean Hispanic 7 0.360 N/A 1 0.015 11.8 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 7 0.366 N/A 1 0.015 11.8 PCs and sequencing center VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.373 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 Caribbean Hispanic 1 0.373 N/A 0 1.3e-03 1.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 Caribbean Hispanic 7 0.373 N/A 1 0.015 11.8 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP MOD-HIGH N/A
NG00065 Caribbean Hispanic 1 0.377 N/A 0 1.3e-03 1.0 PCs and sequencing center VEP HIGH
NG00065 Caribbean Hispanic 1 0.377 N/A 0 1.3e-03 1.0 PCs and sequencing center LOF
NG00065 European 3 0.406 N/A 0 1.9e-04 4.1 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 European 3 0.408 N/A 0 1.9e-04 4.0 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes LOF
NG00065 European 3 0.409 N/A 0 1.9e-04 4.1 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH
NG00065 European 3 0.410 N/A 0 1.9e-04 4.0 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) LOF
NG00065 European 3 0.420 N/A 0 1.9e-04 4.1 PCs and sequencing center VEP HIGH
NG00065 European 3 0.420 N/A 0 1.9e-04 4.0 PCs and sequencing center LOF
NG00065 Meta 4 0.445 N/A 1 2.3e-04 5.1 PCs and sequencing center VEP HIGH
NG00065 Meta 4 0.471 N/A 0 2.3e-04 5.1 PCs, sequencing center, sex, age at AD onset or last-known dementia-free age (for controls), and APOE E2 and E4 genotypes VEP HIGH
NG00065 Meta 4 0.487 N/A 0 2.3e-04 5.1 PCs, sequencing center, sex, and age at AD onset or last-known dementia-free age (for controls) VEP HIGH

Genetic Variation and Variant-based Trait Associations (GWAS)

Variants contained within the APOE gene.

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The APOE gene contains 464 variants records (corresponding to 420 unique genomic positions).

The following variants, contained within ±100kb of APOE, have been found to be associated with Alzheimer's disease in a GWAS study:

NIAGADS GWAS: Alzheimer's Disease

Variants contained within ±100kb of APOE that have genome-wide significance in a NIAGADS Alzheimer's Disease GWAS summary statistics dataset; supported by a p-value < 5 x 10-8. For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

Click on accession numbers to view a detailed report about the dataset or to request access to the data.

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Login in to select variants and add them to your basket.

Relative Position Variant ADSP? Allele p-Value Track Accession
downstream
19:45422946:A:G (rs4420638)
 A 0.000 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45392254:C:T (rs6857)
 T 2.5e-575 IGAP 2013: Stage 1 NG00036
in gene
19:45411941:T:C (rs429358)
 T 1.4e-546 Transethnic LOAD: All Samples NG00056
in gene
19:45411941:T:C (rs429358)
 C 6.7e-536 IGAP 2013: Stage 1 NG00036
in gene
19:45410002:G:A (rs769449)
 A 9.9e-523 IGAP 2013: Stage 1 NG00036
downstream
19:45415713:G:A (rs10414043)
 A 1.2e-522 IGAP 2013: Stage 1 NG00036
downstream
19:45415935:G:T (rs7256200)
 T 1.8e-520 IGAP 2013: Stage 1 NG00036
upstream
19:45396665:G:T (rs59007384)
 T 2.0e-486 IGAP 2013: Stage 1 NG00036
downstream
19:45422160:C:G (rs12721051)
 G 7.8e-482 IGAP 2013: Stage 1 NG00036
upstream
19:45394969:T:G (rs184017)
 G 8.5e-475 IGAP 2013: Stage 1 NG00036
upstream
19:45395714:T:C (rs157581)
 C 8.9e-469 IGAP 2013: Stage 1 NG00036
upstream
19:45395909:C:G (rs34404554)
 G 6.4e-466 IGAP 2013: Stage 1 NG00036
upstream
19:45396144:C:T (rs11556505)
 T 2.6e-464 IGAP 2013: Stage 1 NG00036
upstream
19:45395619:A:G (rs2075650)
 G 5.1e-464 IGAP 2013: Stage 1 NG00036
upstream
19:45394336:T:C (rs71352238)
 C 2.5e-462 IGAP 2013: Stage 1 NG00036
downstream
19:45422846:G:A (rs56131196)
 A 2.0e-454 IGAP 2013: Stage 1 NG00036
upstream
19:45390333:A:G (rs283815)
 G 6.5e-442 IGAP 2013: Stage 1 NG00036
upstream
19:45388130:G:A (rs34342646)
 A 4.9e-440 IGAP 2013: Stage 1 NG00036
downstream
19:45422160:C:G (rs12721051)
 C 3.8e-439 Transethnic LOAD: All Samples NG00056
in gene
19:45410002:G:A (rs769449)
 A 5.3e-435 Transethnic LOAD: All Samples NG00056
upstream
19:45388500:A:G (rs283811)
 G 2.7e-434 IGAP 2013: Stage 1 NG00036
upstream
19:45387459:C:G (rs12972156)
 G 3.2e-434 IGAP 2013: Stage 1 NG00036
upstream
19:45396219:C:T (rs157582)
 T 9.7e-434 IGAP 2013: Stage 1 NG00036
upstream
19:45387596:G:A (rs12972970)
 A 5.4e-432 IGAP 2013: Stage 1 NG00036
downstream
19:45428234:G:A (rs66626994)
 A 2.5e-427 IGAP 2013: Stage 1 NG00036
downstream
19:45421254:G:A (rs12721046)
 A 1.1e-421 IGAP 2013: Stage 1 NG00036
upstream
19:45392254:C:T (rs6857)
 T 4.4e-419 Transethnic LOAD: All Samples NG00056
downstream
19:45422946:A:G (rs4420638)
 A 6.3e-411 Transethnic LOAD: All Samples NG00056
downstream
19:45422846:G:A (rs56131196)
 A 2.2e-410 Transethnic LOAD: All Samples NG00056
downstream
19:45427125:T:A (rs111789331)
 A 7.0e-405 IGAP 2013: Stage 1 NG00036
downstream
19:45422946:A:G (rs4420638)
 G 1.7e-396 IGAP 2013: Stage 1 NG00036
downstream
19:45418790:T:C (rs5117)
 C 8.6e-390 IGAP 2013: Stage 1 NG00036
downstream
19:45420082:A:C (rs73052335)
 A 1.0e-385 Transethnic LOAD: All Samples NG00056
downstream
19:45416178:G:T (rs483082)
 T 2.1e-373 IGAP 2013: Stage 1 NG00036
downstream
19:45421254:G:A (rs12721046)
 A 3.5e-359 Transethnic LOAD: All Samples NG00056
in gene
19:45411941:T:C (rs429358)
 T 6.6e-357 IGAP (2013): ADGC Subset NG00053
upstream
19:45392254:C:T (rs6857)
 T 7.5e-357 IGAP (2013): ADGC Subset NG00053
upstream
19:45395844:G:A (rs34095326)
 A 3.2e-354 IGAP 2013: Stage 1 NG00036
downstream
19:45415935:G:T (rs7256200)
 T 6.3e-353 Transethnic LOAD: All Samples NG00056
downstream
19:45427125:T:A (rs111789331)
 A 3.5e-352 Transethnic LOAD: All Samples NG00056
downstream
19:45415713:G:A (rs10414043)
 A 6.1e-352 Transethnic LOAD: All Samples NG00056
upstream
19:45387459:C:G (rs12972156)
 C 9.0e-350 Transethnic LOAD: All Samples NG00056
upstream
19:45387596:G:A (rs12972970)
 A 1.2e-349 Transethnic LOAD: All Samples NG00056
upstream
19:45388130:G:A (rs34342646)
 A 7.7e-349 Transethnic LOAD: All Samples NG00056
upstream
19:45394336:T:C (rs71352238)
 T 4.4e-344 Transethnic LOAD: All Samples NG00056
upstream
19:45406673:G:A (rs10119)
 A 1.2e-342 IGAP 2013: Stage 1 NG00036
upstream
19:45390333:A:G (rs283815)
 A 1.2e-339 Transethnic LOAD: All Samples NG00056
upstream
19:45395909:C:G (rs34404554)
 C 2.6e-336 Transethnic LOAD: All Samples NG00056
upstream
19:45396219:C:T (rs157582)
 T 2.5e-335 Transethnic LOAD: All Samples NG00056
upstream
19:45388568:T:C (rs283812)
 N/A T 3.0e-333 Transethnic LOAD: All Samples NG00056
downstream
19:45422160:C:G (rs12721051)
 C 7.6e-333 IGAP (2013): ADGC Subset NG00053
upstream
19:45395714:T:C (rs157581)
 T 1.4e-332 Transethnic LOAD: All Samples NG00056
upstream
19:45394969:T:G (rs184017)
 T 9.6e-331 Transethnic LOAD: All Samples NG00056
upstream
19:45396144:C:T (rs11556505)
 T 1.6e-327 Transethnic LOAD: All Samples NG00056
downstream
19:45413576:C:T (rs75627662)
 T 2.8e-326 IGAP 2013: Stage 1 NG00036
downstream
19:45422846:G:A (rs56131196)
 A 4.3e-326 IGAP (2013): ADGC Subset NG00053
upstream
19:45395619:A:G (rs2075650)
 A 3.1e-317 Transethnic LOAD: All Samples NG00056
in gene
19:45410002:G:A (rs769449)
 A 1.4e-313 IGAP (2013): ADGC Subset NG00053
downstream
19:45415713:G:A (rs10414043)
 A 3.4e-311 IGAP (2013): ADGC Subset NG00053
downstream
19:45415935:G:T (rs7256200)
 T 1.2e-310 IGAP (2013): ADGC Subset NG00053
downstream
19:45428234:G:A (rs66626994)
 A 2.2e-309 Transethnic LOAD: All Samples NG00056
downstream
19:45416741:C:T (rs438811)
 T 1.5e-307 Transethnic LOAD: All Samples NG00056
upstream
19:45396665:G:T (rs59007384)
 T 2.8e-300 IGAP (2013): ADGC Subset NG00053
upstream
19:45388500:A:G (rs283811)
 A 7.1e-300 Transethnic LOAD: All Samples NG00056
upstream
19:45396665:G:T (rs59007384)
 T 1.2e-298 Transethnic LOAD: All Samples NG00056
upstream
19:45406673:G:A (rs10119)
 A 8.8e-297 Transethnic LOAD: All Samples NG00056
upstream
19:45394969:T:G (rs184017)
 T 1.8e-294 IGAP (2013): ADGC Subset NG00053
downstream
19:45416178:G:T (rs483082)
 T 1.7e-291 Transethnic LOAD: All Samples NG00056
downstream
19:45428234:G:A (rs66626994)
 A 8.0e-291 IGAP (2013): ADGC Subset NG00053
downstream
19:45421254:G:A (rs12721046)
 A 1.8e-290 IGAP (2013): ADGC Subset NG00053
upstream
19:45395714:T:C (rs157581)
 T 6.4e-290 IGAP (2013): ADGC Subset NG00053
upstream
19:45395909:C:G (rs34404554)
 C 4.5e-288 IGAP (2013): ADGC Subset NG00053
upstream
19:45396144:C:T (rs11556505)
 T 1.7e-286 IGAP (2013): ADGC Subset NG00053
downstream
19:45427125:T:A (rs111789331)
 A 4.9e-286 IGAP (2013): ADGC Subset NG00053
upstream
19:45395619:A:G (rs2075650)
 A 1.5e-285 IGAP (2013): ADGC Subset NG00053
upstream
19:45394336:T:C (rs71352238)
 T 3.3e-285 IGAP (2013): ADGC Subset NG00053
upstream
19:45390333:A:G (rs283815)
 A 2.0e-273 IGAP (2013): ADGC Subset NG00053
upstream
19:45388130:G:A (rs34342646)
 A 1.6e-270 IGAP (2013): ADGC Subset NG00053
upstream
19:45388500:A:G (rs283811)
 A 2.9e-268 IGAP (2013): ADGC Subset NG00053
downstream
19:45422946:A:G (rs4420638)
 A 1.1e-266 ADGC 2011: Stage 1 NG00027
upstream
19:45387459:C:G (rs12972156)
 C 1.3e-263 IGAP (2013): ADGC Subset NG00053
upstream
19:45387596:G:A (rs12972970)
 A 3.0e-263 IGAP (2013): ADGC Subset NG00053
downstream
19:45418790:T:C (rs5117)
 T 1.7e-260 Transethnic LOAD: All Samples NG00056
upstream
19:45396219:C:T (rs157582)
 T 3.0e-254 IGAP (2013): ADGC Subset NG00053
downstream
19:45422946:A:G (rs4420638)
 A 5.7e-243 IGAP (2013): ADGC Subset NG00053
downstream
19:45416178:G:T (rs483082)
 T 2.8e-239 IGAP (2013): ADGC Subset NG00053
downstream
19:45418790:T:C (rs5117)
 T 2.1e-232 IGAP (2013): ADGC Subset NG00053
upstream
19:45406673:G:A (rs10119)
 A 3.1e-226 IGAP (2013): ADGC Subset NG00053
downstream
19:45424351:A:T (rs814573)
 N/A A 3.5e-224 Transethnic LOAD: All Samples NG00056
upstream
19:45395844:G:A (rs34095326)
 A 8.2e-216 Transethnic LOAD: All Samples NG00056
upstream
19:45395844:G:A (rs34095326)
 A 6.4e-212 IGAP (2013): ADGC Subset NG00053
downstream
19:45413576:C:T (rs75627662)
 T 1.7e-210 Transethnic LOAD: All Samples NG00056
upstream
19:45392254:C:T (rs6857)
 T 2.2e-206 ADGC 2011: Stage 1 NG00027
downstream
19:45413576:C:T (rs75627662)
 T 1.4e-204 IGAP (2013): ADGC Subset NG00053
upstream
19:45395619:A:G (rs2075650)
 A 6.2e-184 ADGC 2011: Stage 1 NG00027
upstream
19:45396219:C:T (rs157582)
 T 8.2e-178 ADGC 2011: Stage 1 NG00027
upstream
19:45351516:C:G (rs41289512)
 G 2.2e-167 IGAP 2013: Stage 1 NG00036
downstream
19:45418486:G:A (rs12691088)
 A 1.7e-134 IGAP 2013: Stage 1 NG00036
upstream
19:45395619:A:G (rs2075650)
 A 6.0e-134 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45396144:C:T (rs11556505)
 T 1.4e-133 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45405062:A:G (rs1038026)
 A 1.9e-133 Transethnic LOAD: All Samples NG00056
upstream
19:45395909:C:G (rs34404554)
 C 3.0e-133 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45394336:T:C (rs71352238)
 T 4.9e-133 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45403858:A:G (rs760136)
 A 2.2e-132 Transethnic LOAD: All Samples NG00056
upstream
19:45403412:C:T (rs1160985)
 T 4.7e-132 Transethnic LOAD: All Samples NG00056
upstream
19:45404972:T:C (rs1038025)
 T 9.5e-132 Transethnic LOAD: All Samples NG00056
in gene
19:45411941:T:C (rs429358)
 T 4.3e-131 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45406673:G:A (rs10119)
 A 1.1e-128 ADGC 2011: Stage 1 NG00027
upstream
19:45403858:A:G (rs760136)
 G 1.7e-128 IGAP 2013: Stage 1 NG00036
upstream
19:45404431:T:C (rs741780)
 T 3.6e-128 Transethnic LOAD: All Samples NG00056
upstream
19:45404431:T:C (rs741780)
 C 2.3e-127 IGAP 2013: Stage 1 NG00036
upstream
19:45404972:T:C (rs1038025)
 C 1.0e-126 IGAP 2013: Stage 1 NG00036
upstream
19:45405062:A:G (rs1038026)
 G 1.7e-126 IGAP 2013: Stage 1 NG00036
upstream
19:45407788:G:A (rs7259620)
 A 3.0e-125 Transethnic LOAD: All Samples NG00056
upstream
19:45407788:G:A (rs7259620)
 A 3.3e-125 IGAP 2013: Stage 1 NG00036
upstream
19:45403412:C:T (rs1160985)
 T 6.2e-125 IGAP 2013: Stage 1 NG00036
upstream
19:45396144:C:T (rs11556505)
 N/A 2.8e-122 ADSP Single-Variant Risk Association: European (Model 0) NG00065
upstream
19:45396144:C:T (rs11556505)
 N/A 2.8e-122 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0) NG00065
downstream
19:45422946:A:G (rs4420638)
 A 3.8e-121 ADGC 2011: Stage 2 NG00027
upstream
19:45396144:C:T (rs11556505)
 N/A 2.0e-117 ADSP Single-Variant Risk Association: meta analysis (Model 0) NG00065
downstream
19:45418486:G:A (rs12691088)
 A 8.1e-116 IGAP (2013): ADGC Subset NG00053
upstream
19:45402477:C:T (rs34878901)
 T 3.5e-115 IGAP 2013: Stage 1 NG00036
upstream
19:45401666:A:G (rs8106922)
 G 2.0e-114 IGAP 2013: Stage 1 NG00036
upstream
19:45398817:C:T (rs2238681)
 T 4.8e-114 IGAP 2013: Stage 1 NG00036
upstream
19:45405521:G:C (rs1305062)
 C 3.2e-112 IGAP 2013: Stage 1 NG00036
downstream
19:45421100:G:A (rs3925681)
 A 9.0e-109 IGAP 2013: Stage 1 NG00036
upstream
19:45365447:G:A (rs146275714)
 A 1.5e-108 IGAP 2013: Stage 1 NG00036
in gene
19:45410002:G:A (rs769449)
 A 6.8e-106 AD Age of Onset Survival (IGAP) NG00058
in gene
19:45410444:G:A (rs769450)
 A 5.1e-104 IGAP 2013: Stage 1 NG00036
upstream
19:45351516:C:G (rs41289512)
 C 1.9e-103 IGAP (2013): ADGC Subset NG00053
downstream
19:45415713:G:A (rs10414043)
 A 3.0e-102 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45395266:G:A (rs157580)
 G 1.2e-101 IGAP 2013: Stage 1 NG00036
in gene
19:45410444:G:A (rs769450)
 A 1.4e-101 Transethnic LOAD: All Samples NG00056
downstream
19:45415935:G:T (rs7256200)
 T 1.4e-101 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45422946:A:G (rs4420638)
 A 2.2e-101 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45422846:G:A (rs56131196)
 A 2.3e-101 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45425460:A:G (rs157595)
 A 3.8e-101 IGAP 2013: Stage 1 NG00036
downstream
19:45422160:C:G (rs12721051)
 C 1.3e-100 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45421100:G:A (rs3925681)
 A 4.8e-100 Transethnic LOAD: All Samples NG00056
upstream
19:45408836:T:G (rs405509)
 T 2.3e-99 Transethnic LOAD: All Samples NG00056
upstream
19:45405521:G:C (rs1305062)
 C 8.3e-99 Transethnic LOAD: All Samples NG00056
upstream
19:45365447:G:A (rs146275714)
 A 2.0e-98 IGAP (2013): ADGC Subset NG00053
upstream
19:45402477:C:T (rs34878901)
 T 9.1e-98 Transethnic LOAD: All Samples NG00056
upstream
19:45395330:A:G (rs2075649)
 G 5.4e-97 IGAP 2013: Stage 1 NG00036
upstream
19:45401666:A:G (rs8106922)
 A 8.5e-97 Transethnic LOAD: All Samples NG00056
upstream
19:45392254:C:T (rs6857)
 T 3.3e-96 ADGC Age of Onset LOAD NG00048
upstream
19:45382034:A:G (rs6859)
 A 3.3e-96 IGAP 2013: Stage 1 NG00036
upstream
19:45392254:C:T (rs6857)
 T 3.7e-96 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45395266:G:A (rs157580)
 A 2.0e-95 Transethnic LOAD: All Samples NG00056
downstream
19:45420082:A:C (rs73052335)
 A 3.8e-95 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45398817:C:T (rs2238681)
 T 1.2e-94 Transethnic LOAD: All Samples NG00056
upstream
19:45396665:G:T (rs59007384)
 T 1.1e-93 ADGC Age of Onset LOAD NG00048
upstream
19:45394969:T:G (rs184017)
 T 3.5e-93 ADGC Age of Onset LOAD NG00048
downstream
19:45425460:A:G (rs157595)
 A 1.3e-92 Transethnic LOAD: All Samples NG00056
downstream
19:45416291:C:T (rs59325138)
 T 6.9e-89 IGAP 2013: Stage 1 NG00036
in gene
19:45411941:T:C (rs429358)
 T 8.1e-89 ADGC Age of Onset LOAD NG00048
upstream
19:45357291:G:C (rs4803763)
 C 9.9e-89 IGAP 2013: Stage 1 NG00036
downstream
19:45428459:C:T (rs4803772)
 T 1.3e-88 IGAP 2013: Stage 1 NG00036
upstream
19:45357377:T:C (rs4803764)
 C 4.2e-87 IGAP 2013: Stage 1 NG00036
upstream
19:45395266:G:A (rs157580)
 A 5.4e-87 IGAP (2013): ADGC Subset NG00053
upstream
19:45357003:C:G (rs35396326)
 G 1.4e-86 IGAP 2013: Stage 1 NG00036
downstream
19:45416291:C:T (rs59325138)
 T 3.0e-86 Transethnic LOAD: All Samples NG00056
upstream
19:45359586:C:T (rs56317818)
 T 1.8e-85 IGAP 2013: Stage 1 NG00036
upstream
19:45385759:G:C (rs3745150)
 C 2.8e-85 IGAP 2013: Stage 1 NG00036
downstream
19:45421877:A:G (rs484195)
 A 2.9e-85 Transethnic LOAD: All Samples NG00056
upstream
19:45356464:T:A (rs73050205)
 A 2.9e-85 IGAP 2013: Stage 1 NG00036
downstream
19:45423636:G:A (rs78959900)
 A 3.9e-85 IGAP 2013: Stage 1 NG00036
downstream
19:45425175:T:G (rs157594)
 T 9.0e-85 Transethnic LOAD: All Samples NG00056
upstream
19:45388568:T:C (rs283812)
 N/A T 1.1e-84 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45395714:T:C (rs157581)
 N/A 1.7e-84 ADSP Single-Variant Risk Association: European (Model 0) NG00065
upstream
19:45395714:T:C (rs157581)
 N/A 1.7e-84 ADSP Single-Variant Risk Association: Caribbean Hispanic (Model 0) NG00065
downstream
19:45425460:A:G (rs157595)
 A 2.3e-84 IGAP (2013): ADGC Subset NG00053
upstream
19:45390333:A:G (rs283815)
 A 3.4e-84 ADGC Age of Onset LOAD NG00048
downstream
19:45422160:C:G (rs12721051)
 C 5.0e-84 ADGC Age of Onset LOAD NG00048
downstream
19:45427353:C:G (rs4803770)
 G 1.1e-83 IGAP 2013: Stage 1 NG00036
downstream
19:45416478:A:G (rs584007)
 A 1.1e-82 IGAP 2013: Stage 1 NG00036
downstream
19:45421744:G:T (rs12721056)
 T 1.2e-82 IGAP 2013: Stage 1 NG00036
upstream
19:45403858:A:G (rs760136)
 A 1.3e-82 IGAP (2013): ADGC Subset NG00053
upstream
19:45355721:C:G (rs2972559)
 G 3.4e-82 IGAP 2013: Stage 1 NG00036
downstream
19:45425175:T:G (rs157594)
 T 4.3e-82 IGAP 2013: Stage 1 NG00036
downstream
19:45422846:G:A (rs56131196)
 A 5.1e-82 ADGC Age of Onset LOAD NG00048
upstream
19:45395714:T:C (rs157581)
 N/A 1.1e-81 ADSP Single-Variant Risk Association: meta analysis (Model 0) NG00065
upstream
19:45404431:T:C (rs741780)
 T 1.1e-81 IGAP (2013): ADGC Subset NG00053
upstream
19:45404972:T:C (rs1038025)
 T 3.1e-81 IGAP (2013): ADGC Subset NG00053
upstream
19:45395714:T:C (rs157581)
 T 4.6e-81 ADGC Age of Onset LOAD NG00048
upstream
19:45405062:A:G (rs1038026)
 A 6.5e-81 IGAP (2013): ADGC Subset NG00053
upstream
19:45359706:G:A (rs12462573)
 A 7.8e-81 IGAP 2013: Stage 1 NG00036
upstream
19:45398716:A:C (rs157590)
 C 1.1e-80 IGAP 2013: Stage 1 NG00036
upstream
19:45403412:C:T (rs1160985)
 T 1.6e-80 IGAP (2013): ADGC Subset NG00053
upstream
19:45396665:G:T (rs59007384)
 T 1.8e-80 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45427125:T:A (rs111789331)
 A 1.9e-80 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45414451:T:C (rs439401)
 T 2.3e-80 Transethnic LOAD: All Samples NG00056
downstream
19:45428234:G:A (rs66626994)
 A 6.3e-80 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45427353:C:G (rs4803770)
 C 1.1e-79 Transethnic LOAD: All Samples NG00056
downstream
19:45416478:A:G (rs584007)
 A 2.8e-79 Transethnic LOAD: All Samples NG00056
downstream
19:45414451:T:C (rs439401)
 T 3.5e-79 IGAP 2013: Stage 1 NG00036
upstream
19:45407788:G:A (rs7259620)
 A 4.9e-79 IGAP (2013): ADGC Subset NG00053
upstream
19:45388500:A:G (rs283811)
 A 8.8e-79 ADGC Age of Onset LOAD NG00048
downstream
19:45421254:G:A (rs12721046)
 A 1.8e-78 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45421744:G:T (rs12721056)
 T 1.9e-77 Transethnic LOAD: All Samples NG00056
upstream
19:45390333:A:G (rs283815)
 A 3.4e-77 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45423636:G:A (rs78959900)
 A 1.2e-76 Transethnic LOAD: All Samples NG00056
upstream
19:45396219:C:T (rs157582)
 T 1.6e-76 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45396973:G:A (rs77301115)
 A 2.1e-76 IGAP 2013: Stage 1 NG00036
upstream
19:45397512:A:C (rs157585)
 C 2.8e-76 IGAP 2013: Stage 1 NG00036
upstream
19:45398264:C:T (rs157588)
 T 2.8e-76 IGAP 2013: Stage 1 NG00036
upstream
19:45395714:T:C (rs157581)
 T 3.9e-76 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45394969:T:G (rs184017)
 T 2.3e-75 AD Age of Onset Survival (IGAP) NG00058
in gene
19:45410002:G:A (rs769449)
 A 2.4e-75 ADGC Age of Onset LOAD NG00048
downstream
19:45416178:G:T (rs483082)
 T 1.5e-74 ADGC Age of Onset LOAD NG00048
downstream
19:45429708:G:C (rs60049679)
 C 2.4e-74 Transethnic LOAD: All Samples NG00056
upstream
19:45382034:A:G (rs6859)
 A 5.8e-74 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45408836:T:G (rs405509)
 G 4.4e-73 IGAP 2013: Stage 1 NG00036
upstream
19:45395330:A:G (rs2075649)
 A 4.5e-73 Transethnic LOAD: All Samples NG00056
downstream
19:45422946:A:G (rs4420638)
 A 4.5e-73 ADGC Age of Onset LOAD NG00048
downstream
19:45415713:G:A (rs10414043)
 A 1.1e-72 ADGC Age of Onset LOAD NG00048
upstream
19:45348522:G:T (rs12162222)
 T 3.9e-72 IGAP 2013: Stage 1 NG00036
downstream
19:45428459:C:T (rs4803772)
 T 7.8e-72 Transethnic LOAD: All Samples NG00056
downstream
19:45418961:T:C (rs3826688)
 T 9.0e-72 Transethnic LOAD: All Samples NG00056
upstream
19:45382034:A:G (rs6859)
 A 3.2e-71 Transethnic LOAD: All Samples NG00056
downstream
19:45416478:A:G (rs584007)
 A 5.4e-71 IGAP (2013): ADGC Subset NG00053
upstream
19:45387459:C:G (rs12972156)
 C 6.0e-71 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45387596:G:A (rs12972970)
 A 6.5e-71 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45388130:G:A (rs34342646)
 A 8.8e-71 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45395909:C:G (rs34404554)
 C 9.5e-71 ADGC Age of Onset LOAD NG00048
upstream
19:45404857:T:C (rs112019714)
 T 1.0e-70 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45412955:A:C (rs1081105)
 A 1.8e-70 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45394336:T:C (rs71352238)
 T 4.3e-70 ADGC Age of Onset LOAD NG00048
in gene
19:45409167:C:G (rs440446)
 C 9.5e-70 Transethnic LOAD: All Samples NG00056
upstream
19:45396219:C:T (rs157582)
 T 1.1e-69 ADGC Age of Onset LOAD NG00048
downstream
19:45414451:T:C (rs439401)
 T 1.7e-69 IGAP (2013): ADGC Subset NG00053
upstream
19:45388500:A:G (rs283811)
 A 2.8e-69 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45399344:G:T (rs75687619)
 T 3.0e-69 IGAP 2013: Stage 1 NG00036
downstream
19:45427125:T:A (rs111789331)
 A 3.4e-69 ADGC Age of Onset LOAD NG00048
upstream
19:45385759:G:C (rs3745150)
 C 3.5e-69 Transethnic LOAD: All Samples NG00056
upstream
19:45398785:C:T (rs79398853)
 T 3.8e-69 IGAP 2013: Stage 1 NG00036
upstream
19:45397952:T:C (rs116881820)
 C 4.7e-69 IGAP 2013: Stage 1 NG00036
upstream
19:45324138:G:A (rs28399637)
 A 4.7e-69 IGAP 2013: Stage 1 NG00036
upstream
19:45397307:C:T (rs112849259)
 T 5.4e-69 IGAP 2013: Stage 1 NG00036
downstream
19:45428234:G:A (rs66626994)
 A 6.7e-69 ADGC Age of Onset LOAD NG00048
upstream
19:45402477:C:T (rs34878901)
 T 7.5e-69 IGAP (2013): ADGC Subset NG00053
upstream
19:45398817:C:T (rs2238681)
 T 2.4e-68 IGAP (2013): ADGC Subset NG00053
downstream
19:45418961:T:C (rs3826688)
 T 6.3e-68 IGAP 2013: Stage 1 NG00036
upstream
19:45401666:A:G (rs8106922)
 A 8.0e-68 IGAP (2013): ADGC Subset NG00053
upstream
19:45327423:G:T (rs4803758)
 N/A T 1.2e-67 IGAP 2013: Stage 1 NG00036
downstream
19:45421100:G:A (rs3925681)
 A 1.6e-67 IGAP (2013): ADGC Subset NG00053
in gene
19:45409167:C:G (rs440446)
 C 1.6e-67 IGAP (2013): ADGC Subset NG00053
upstream
19:45400725:C:T (rs114536010)
 T 1.8e-67 IGAP 2013: Stage 1 NG00036
upstream
19:45399896:G:A (rs76366838)
 A 2.0e-67 IGAP 2013: Stage 1 NG00036
in gene
19:45409167:C:G (rs440446)
 C 2.3e-67 IGAP 2013: Stage 1 NG00036
upstream
19:45395619:A:G (rs2075650)
 A 2.8e-67 ADGC Age of Onset LOAD NG00048
upstream
19:45357291:G:C (rs4803763)
 C 2.9e-67 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45327309:C:T (rs10412413)
 T 3.3e-67 IGAP 2013: Stage 1 NG00036
downstream
19:45421254:G:A (rs12721046)
 A 3.7e-67 ADGC Age of Onset LOAD NG00048
upstream
19:45405521:G:C (rs1305062)
 C 4.6e-67 IGAP (2013): ADGC Subset NG00053
upstream
19:45403216:C:T (rs115881343)
 T 4.8e-67 IGAP 2013: Stage 1 NG00036
upstream
19:45384405:T:C (rs73052307)
 N/A C 4.9e-67 IGAP 2013: Stage 1 NG00036
upstream
19:45404857:T:C (rs112019714)
 C 5.5e-67 IGAP 2013: Stage 1 NG00036
upstream
19:45396899:T:C (rs157584)
 C 1.2e-66 IGAP 2013: Stage 1 NG00036
downstream
19:45424351:A:T (rs814573)
 N/A A 8.9e-66 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45337504:G:C (rs11667241)
 C 1.5e-65 IGAP 2013: Stage 1 NG00036
upstream
19:45336443:G:A (rs3021439)
 A 1.8e-65 IGAP 2013: Stage 1 NG00036
downstream
19:45412955:A:C (rs1081105)
 C 2.0e-65 IGAP 2013: Stage 1 NG00036
downstream
19:45416741:C:T (rs438811)
 T 2.3e-65 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45416178:G:T (rs483082)
 T 3.5e-65 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45345623:G:A (rs2199575)
 A 4.1e-65 IGAP 2013: Stage 1 NG00036
downstream
19:45421877:A:G (rs484195)
 A 4.1e-65 IGAP 2013: Stage 1 NG00036
upstream
19:45336035:T:C (rs7359852)
 C 4.4e-65 IGAP 2013: Stage 1 NG00036
upstream
19:45326217:T:C (rs10406338)
 C 1.4e-64 IGAP 2013: Stage 1 NG00036
upstream
19:45328367:A:T (rs58132661)
 T 2.6e-64 IGAP 2013: Stage 1 NG00036
downstream
19:45418790:T:C (rs5117)
 T 4.8e-64 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45329344:T:C (rs10402524)
 C 9.3e-64 IGAP 2013: Stage 1 NG00036
downstream
19:45415935:G:T (rs7256200)
 T 1.0e-63 ADGC Age of Onset LOAD NG00048
upstream
19:45324138:G:A (rs28399637)
 A 1.6e-63 Transethnic LOAD: All Samples NG00056
upstream
19:45337249:C:A (rs2927481)
 A 2.2e-63 IGAP 2013: Stage 1 NG00036
upstream
19:45341904:G:A (rs12459575)
 A 2.6e-63 IGAP 2013: Stage 1 NG00036
upstream
19:45342007:G:C (rs74579864)
 C 1.1e-62 IGAP 2013: Stage 1 NG00036
downstream
19:45413576:C:T (rs75627662)
 T 1.6e-62 ADGC Age of Onset LOAD NG00048
upstream
19:45338523:G:C (rs73048288)
 C 2.7e-62 IGAP 2013: Stage 1 NG00036
upstream
19:45342161:G:A (rs4803762)
 A 2.8e-62 IGAP 2013: Stage 1 NG00036
downstream
19:45429543:C:T (rs71352239)
 T 4.6e-62 IGAP 2013: Stage 1 NG00036
upstream
19:45396144:C:T (rs11556505)
 T 5.2e-62 ADGC Age of Onset LOAD NG00048
downstream
19:45418961:T:C (rs3826688)
 T 2.5e-61 IGAP (2013): ADGC Subset NG00053
upstream
19:45341540:A:G (rs12462274)
 G 7.7e-61 IGAP 2013: Stage 1 NG00036
upstream
19:45326664:C:T (rs10405693)
 T 1.2e-60 IGAP 2013: Stage 1 NG00036
upstream
19:45387459:C:G (rs12972156)
 C 1.6e-60 ADGC Age of Onset LOAD NG00048
downstream
19:45425175:T:G (rs157594)
 T 4.2e-60 IGAP (2013): ADGC Subset NG00053
upstream
19:45329214:T:G (rs10402271)
 G 6.2e-60 IGAP 2013: Stage 1 NG00036
in gene
19:45410444:G:A (rs769450)
 A 2.4e-59 IGAP (2013): ADGC Subset NG00053
upstream
19:45342114:A:G (rs4803761)
 G 4.8e-59 IGAP 2013: Stage 1 NG00036
upstream
19:45406673:G:A (rs10119)
 A 6.2e-59 ADGC Age of Onset LOAD NG00048
upstream
19:45357939:A:G (rs2927468)
 A 1.7e-58 IGAP 2013: Stage 1 NG00036
upstream
19:45398633:G:C (rs11668327)
 C 4.8e-58 IGAP 2013: Stage 1 NG00036
upstream
19:45395330:A:G (rs2075649)
 A 8.6e-58 IGAP (2013): ADGC Subset NG00053
upstream
19:45404857:T:C (rs112019714)
 T 1.1e-57 Transethnic LOAD: All Samples NG00056
upstream
19:45396973:G:A (rs77301115)
 A 4.7e-57 Transethnic LOAD: All Samples NG00056
upstream
19:45382034:A:G (rs6859)
 A 6.2e-57 IGAP (2013): ADGC Subset NG00053
downstream
19:45412955:A:C (rs1081105)
 A 1.1e-56 Transethnic LOAD: All Samples NG00056
downstream
19:45421650:G:A (rs140480140)
 A 1.7e-56 Transethnic LOAD: All Samples NG00056
upstream
19:45403216:C:T (rs115881343)
 T 2.8e-56 Transethnic LOAD: All Samples NG00056
downstream
19:45418790:T:C (rs5117)
 T 3.1e-56 ADGC Age of Onset LOAD NG00048
upstream
19:45388130:G:A (rs34342646)
 A 7.3e-56 ADGC Age of Onset LOAD NG00048
upstream
19:45398633:G:C (rs11668327)
 C 1.1e-55 Transethnic LOAD: All Samples NG00056
upstream
19:45400725:C:T (rs114536010)
 T 1.5e-55 Transethnic LOAD: All Samples NG00056
upstream
19:45399344:G:T (rs75687619)
 T 3.3e-55 Transethnic LOAD: All Samples NG00056
upstream
19:45399896:G:A (rs76366838)
 A 8.5e-55 Transethnic LOAD: All Samples NG00056
upstream
19:45357291:G:C (rs4803763)
 C 9.0e-55 IGAP (2013): ADGC Subset NG00053
downstream
19:45421877:A:G (rs484195)
 A 9.2e-55 IGAP (2013): ADGC Subset NG00053
downstream
19:45425066:G:A (rs188535946)
 N/A A 1.2e-54 Transethnic LOAD: All Samples NG00056
upstream
19:45397307:C:T (rs112849259)
 T 1.3e-54 Transethnic LOAD: All Samples NG00056
upstream
19:45395266:G:A (rs157580)
 A 1.4e-54 ADGC 2011: Stage 1 NG00027
upstream
19:45359586:C:T (rs56317818)
 T 3.2e-54 IGAP (2013): ADGC Subset NG00053
upstream
19:45357377:T:C (rs4803764)
 T 3.9e-54 IGAP (2013): ADGC Subset NG00053
upstream
19:45357003:C:G (rs35396326)
 C 4.8e-54 IGAP (2013): ADGC Subset NG00053
upstream
19:45387596:G:A (rs12972970)
 A 2.0e-53 ADGC Age of Onset LOAD NG00048
upstream
19:45398716:A:C (rs157590)
 A 3.1e-53 Transethnic LOAD: All Samples NG00056
upstream
19:45398785:C:T (rs79398853)
 T 3.2e-53 Transethnic LOAD: All Samples NG00056
upstream
19:45356464:T:A (rs73050205)
 A 5.2e-53 IGAP (2013): ADGC Subset NG00053
upstream
19:45328379:T:A (rs58826447)
 A 5.4e-53 IGAP 2013: Stage 1 NG00036
upstream
19:45328380:C:A (rs58446550)
 A 5.5e-53 IGAP 2013: Stage 1 NG00036
downstream
19:45416291:C:T (rs59325138)
 T 1.3e-52 IGAP (2013): ADGC Subset NG00053
upstream
19:45401868:T:C (rs118170342)
 C 1.7e-52 IGAP 2013: Stage 1 NG00036
upstream
19:45359706:G:A (rs12462573)
 A 3.2e-52 IGAP (2013): ADGC Subset NG00053
upstream
19:45385759:G:C (rs3745150)
 C 3.4e-52 IGAP (2013): ADGC Subset NG00053
upstream
19:45382966:C:T (rs3852860)
 T 3.9e-52 IGAP 2013: Stage 1 NG00036
upstream
19:45384116:G:A (rs406315)
 G 5.5e-52 IGAP 2013: Stage 1 NG00036
upstream
19:45327423:G:T (rs4803758)
 N/A T 7.8e-52 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45327309:C:T (rs10412413)
 T 8.1e-52 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45398264:C:T (rs157588)
 T 8.5e-52 Transethnic LOAD: All Samples NG00056
downstream
19:45428459:C:T (rs4803772)
 T 9.1e-52 IGAP (2013): ADGC Subset NG00053
upstream
19:45397512:A:C (rs157585)
 A 1.2e-51 Transethnic LOAD: All Samples NG00056
upstream
19:45395844:G:A (rs34095326)
 A 1.2e-51 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45357377:T:C (rs4803764)
 T 1.3e-51 Transethnic LOAD: All Samples NG00056
downstream
19:45429543:C:T (rs71352239)
 T 2.5e-51 Transethnic LOAD: All Samples NG00056
upstream
19:45329344:T:C (rs10402524)
 T 3.9e-51 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45356464:T:A (rs73050205)
 A 4.4e-51 Transethnic LOAD: All Samples NG00056
upstream
19:45326664:C:T (rs10405693)
 T 4.7e-51 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45398716:A:C (rs157590)
 A 5.7e-51 IGAP (2013): ADGC Subset NG00053
upstream
19:45404691:A:G (rs405697)
 A 1.4e-50 IGAP (2013): ADGC Subset NG00053
downstream
19:45423636:G:A (rs78959900)
 A 1.7e-50 IGAP (2013): ADGC Subset NG00053
upstream
19:45357291:G:C (rs4803763)
 C 2.1e-50 Transethnic LOAD: All Samples NG00056
upstream
19:45404691:A:G (rs405697)
 A 2.3e-50 IGAP 2013: Stage 1 NG00036
upstream
19:45355721:C:G (rs2972559)
 C 2.4e-50 IGAP (2013): ADGC Subset NG00053
upstream
19:45382034:A:G (rs6859)
 A 2.5e-50 ADGC 2011: Stage 1 NG00027
upstream
19:45329214:T:G (rs10402271)
 T 3.8e-50 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45359586:C:T (rs56317818)
 T 4.0e-50 Transethnic LOAD: All Samples NG00056
upstream
19:45355721:C:G (rs2972559)
 C 8.5e-50 Transethnic LOAD: All Samples NG00056
upstream
19:45388588:A:T (rs200573101)
 N/A I 1.7e-49 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45388588:A:ATT (rs35951235)
 N/A I 1.7e-49 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45359706:G:A (rs12462573)
 A 1.9e-49 Transethnic LOAD: All Samples NG00056
downstream
19:45427353:C:G (rs4803770)
 C 1.9e-49 IGAP (2013): ADGC Subset NG00053
downstream
19:45421744:G:T (rs12721056)
 T 8.4e-49 IGAP (2013): ADGC Subset NG00053
upstream
19:45397952:T:C (rs116881820)
 T 1.3e-48 Transethnic LOAD: All Samples NG00056
upstream
19:45395844:G:A (rs34095326)
 A 5.5e-48 ADGC Age of Onset LOAD NG00048
downstream
19:45413576:C:T (rs75627662)
 T 1.8e-47 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45337385:G:C (rs2927480)
 C 2.7e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45336035:T:C (rs7359852)
 T 3.9e-47 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45357291:G:C (rs4803763)
 C 5.0e-47 ADGC 2011: Stage 1 NG00027
in gene
19:45411941:T:C (rs429358)
 T 5.5e-47 ADGC African Americans 2013 NG00039
upstream
19:45383061:G:T (rs3852861)
 T 8.3e-47 IGAP 2013: Stage 1 NG00036
upstream
19:45398264:C:T (rs157588)
 T 3.5e-46 IGAP (2013): ADGC Subset NG00053
upstream
19:45397512:A:C (rs157585)
 A 3.8e-46 IGAP (2013): ADGC Subset NG00053
upstream
19:45358353:T:C (rs10410835)
 T 1.3e-45 IGAP 2013: Stage 1 NG00036
upstream
19:45386634:C:T (rs147636938)
 T 1.4e-45 Transethnic LOAD: All Samples NG00056
upstream
19:45326217:T:C (rs10406338)
 T 1.7e-45 Transethnic LOAD: All Samples NG00056
upstream
19:45382717:G:A (rs406456)
 G 1.8e-45 IGAP 2013: Stage 1 NG00036
upstream
19:45326664:C:T (rs10405693)
 T 3.3e-45 Transethnic LOAD: All Samples NG00056
upstream
19:45401666:A:G (rs8106922)
 A 5.1e-45 ADGC 2011: Stage 1 NG00027
downstream
19:45414451:T:C (rs439401)
 T 5.6e-45 ADGC 2011: Stage 1 NG00027
upstream
19:45384405:T:C (rs73052307)
 N/A T 6.0e-45 IGAP (2013): ADGC Subset NG00053
upstream
19:45398633:G:C (rs11668327)
 C 6.1e-45 IGAP (2013): ADGC Subset NG00053
upstream
19:45331725:C:T (rs4802238)
 T 7.4e-45 Transethnic LOAD: All Samples NG00056
upstream
19:45354296:A:G (rs11666329)
 A 1.4e-44 IGAP 2013: Stage 1 NG00036
upstream
19:45357003:C:G (rs35396326)
 C 1.5e-44 Transethnic LOAD: All Samples NG00056
upstream
19:45408836:T:G (rs405509)
 T 3.0e-44 ADGC 2011: Stage 1 NG00027
downstream
19:45429543:C:T (rs71352239)
 T 3.5e-44 IGAP (2013): ADGC Subset NG00053
upstream
19:45396899:T:C (rs157584)
 T 4.1e-44 Transethnic LOAD: All Samples NG00056
upstream
19:45327309:C:T (rs10412413)
 T 4.3e-44 Transethnic LOAD: All Samples NG00056
upstream
19:45327423:G:T (rs4803758)
 N/A T 4.4e-44 Transethnic LOAD: All Samples NG00056
in gene
19:45412079:C:T (rs7412)
 N/A T 5.9e-44 Transethnic LOAD: All Samples NG00056
upstream
19:45329214:T:G (rs10402271)
 T 8.7e-44 ADGC 2011: Stages 1 and 2 NG00027
upstream
19:45328367:A:T (rs58132661)
 A 1.1e-43 Transethnic LOAD: All Samples NG00056
upstream
19:45357939:A:G (rs2927468)
 A 4.2e-43 IGAP (2013): ADGC Subset NG00053
upstream
19:45329214:T:G (rs10402271)
 T 4.7e-42 Transethnic LOAD: All Samples NG00056
upstream
19:45404691:A:G (rs405697)
 A 6.2e-42 Transethnic LOAD: All Samples NG00056
upstream
19:45348522:G:T (rs12162222)
 T 7.3e-42 IGAP (2013): ADGC Subset NG00053
upstream
19:45396973:G:A (rs77301115)
 A 8.2e-42 IGAP (2013): ADGC Subset NG00053
upstream
19:45329344:T:C (rs10402524)
 T 1.0e-41 Transethnic LOAD: All Samples NG00056
upstream
19:45328380:C:A (rs58446550)
 A 5.7e-41 Transethnic LOAD: All Samples NG00056
upstream
19:45328379:T:A (rs58826447)
 A 5.8e-41 Transethnic LOAD: All Samples NG00056
upstream
19:45386467:G:GTAA (rs142042446)
 N/A I 6.9e-41 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45324138:G:A (rs28399637)
 A 1.9e-40 IGAP (2013): ADGC Subset NG00053
upstream
19:45327423:G:T (rs4803758)
 N/A T 1.9e-40 IGAP (2013): ADGC Subset NG00053
downstream
19:45421204:C:T (rs150966173)
 T 2.3e-40 IGAP 2013: Stage 1 NG00036
upstream
19:45380970:G:T (rs11668861)
 T 2.9e-40 IGAP 2013: Stage 1 NG00036
downstream
19:45421650:G:A (rs140480140)
 A 3.4e-40 IGAP 2013: Stage 1 NG00036
upstream
19:45348522:G:T (rs12162222)
 T 3.7e-40 Transethnic LOAD: All Samples NG00056
upstream
19:45327309:C:T (rs10412413)
 T 4.2e-40 IGAP (2013): ADGC Subset NG00053
upstream
19:45345623:G:A (rs2199575)
 A 5.4e-40 Transethnic LOAD: All Samples NG00056
upstream
19:45408564:A:T (rs449647)
 T 1.5e-39 IGAP 2013: Stage 1 NG00036
upstream
19:45396899:T:C (rs157584)
 T 2.0e-39 IGAP (2013): ADGC Subset NG00053
upstream
19:45363820:T:G (rs138607350)
 G 2.2e-39 IGAP 2013: Stage 1 NG00036
downstream
19:45417632:C:CCCTT (rs201225864)
 N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45417638:C:CTTCG (rs11568822)
 N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45417638:C:G (rs79626409)
 N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
downstream
19:45417638:C:CTTCG (rs34954997)
 N/A I 3.8e-39 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45328367:A:T (rs58132661)
 A 4.7e-39 IGAP (2013): ADGC Subset NG00053
upstream
19:45326217:T:C (rs10406338)
 T 1.0e-38 IGAP (2013): ADGC Subset NG00053
upstream
19:45336443:G:A (rs3021439)
 A 1.3e-38 IGAP (2013): ADGC Subset NG00053
upstream
19:45383061:G:T (rs3852861)
 T 1.4e-38 Transethnic LOAD: All Samples NG00056
upstream
19:45382966:C:T (rs3852860)
 T 1.9e-38 Transethnic LOAD: All Samples NG00056
upstream
19:45337504:G:C (rs11667241)
 C 2.7e-38 IGAP (2013): ADGC Subset NG00053
upstream
19:45336035:T:C (rs7359852)
 T 5.9e-38 IGAP (2013): ADGC Subset NG00053
upstream
19:45341540:A:G (rs12462274)
 A 9.9e-38 Transethnic LOAD: All Samples NG00056
upstream
19:45326217:T:C (rs10406338)
 T 1.1e-37 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45337249:C:A (rs2927481)
 A 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45342007:G:C (rs74579864)
 C 1.8e-37 Transethnic LOAD: All Samples NG00056
upstream
19:45399344:G:T (rs75687619)
 T 1.8e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45329344:T:C (rs10402524)
 T 2.0e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45398785:C:T (rs79398853)
 T 2.1e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45338523:G:C (rs73048288)
 C 2.4e-37 Transethnic LOAD: All Samples NG00056
upstream
19:45397952:T:C (rs116881820)
 T 2.5e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45397307:C:T (rs112849259)
 T 2.7e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45341904:G:A (rs12459575)
 A 5.8e-37 IGAP (2013): ADGC Subset NG00053
upstream
19:45338523:G:C (rs73048288)
 C 1.9e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45341540:A:G (rs12462274)
 A 2.1e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45393516:C:T (rs117310449)
 T 3.7e-36 IGAP 2013: Stage 1 NG00036
upstream
19:45342114:A:G (rs4803761)
 A 3.8e-36 Transethnic LOAD: All Samples NG00056
downstream
19:45412955:A:C (rs1081105)
 A 4.6e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45342161:G:A (rs4803762)
 A 4.9e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45345623:G:A (rs2199575)
 A 5.1e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45341948:A:G (rs10407439)
 A 5.3e-36 IGAP 2013: Stage 1 NG00036
upstream
19:45342007:G:C (rs74579864)
 C 6.3e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45408836:T:G (rs405509)
 T 8.4e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45400725:C:T (rs114536010)
 T 8.9e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45399896:G:A (rs76366838)
 A 9.3e-36 IGAP (2013): ADGC Subset NG00053
upstream
19:45357939:A:G (rs2927468)
 A 9.5e-36 Transethnic LOAD: All Samples NG00056
upstream
19:45401868:T:C (rs118170342)
 T 1.0e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45404857:T:C (rs112019714)
 T 1.1e-35 IGAP (2013): ADGC Subset NG00053
upstream
19:45403216:C:T (rs115881343)
 T 1.1e-35 IGAP (2013): ADGC Subset NG00053
upstream
19:45384405:T:C (rs73052307)
 N/A T 1.2e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45358353:T:C (rs10410835)
 T 1.9e-35 IGAP (2013): ADGC Subset NG00053
upstream
19:45380970:G:T (rs11668861)
 T 1.9e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45340736:G:A (rs73048293)
 A 2.8e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45337385:G:C (rs2927480)
 C 3.3e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45341904:G:A (rs12459575)
 A 9.3e-35 Transethnic LOAD: All Samples NG00056
upstream
19:45394211:C:T (rs76692773)
 T 1.2e-34 IGAP 2013: Stage 1 NG00036
upstream
19:45358353:T:C (rs10410835)
 T 5.8e-34 Transethnic LOAD: All Samples NG00056
upstream
19:45342114:A:G (rs4803761)
 A 9.1e-34 IGAP (2013): ADGC Subset NG00053
upstream
19:45382675:G:A (rs41290120)
 A 1.4e-33 IGAP 2013: Stage 1 NG00036
upstream
19:45337385:G:C (rs2927480)
 C 1.6e-33 ADGC 2011: Stage 1 NG00027
upstream
19:45326664:C:T (rs10405693)
 T 1.7e-33 IGAP (2013): ADGC Subset NG00053
upstream
19:45336035:T:C (rs7359852)
 T 1.8e-33 ADGC 2011: Stage 1 NG00027
upstream
19:45336443:G:A (rs3021439)
 A 2.0e-33 Transethnic LOAD: All Samples NG00056
upstream
19:45392254:C:T (rs6857)
 T 2.3e-33 Transethnic LOAD: APOE e4 Carriers NG00056
upstream
19:45352487:A:T (rs12974942)
 T 5.5e-33 IGAP 2013: Stage 1 NG00036
upstream
19:45329214:T:G (rs10402271)
 T 8.7e-33 IGAP (2013): ADGC Subset NG00053
upstream
19:45385759:G:C (rs3745150)
 C 2.4e-32 ADGC 2011: Stage 1 NG00027
upstream
19:45336035:T:C (rs7359852)
 T 2.6e-32 Transethnic LOAD: All Samples NG00056
downstream
19:45418486:G:A (rs12691088)
 A 3.1e-32 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45349402:T:C (rs3810143)
 C 4.7e-32 IGAP 2013: Stage 1 NG00036
upstream
19:45351516:C:G (rs41289512)
 C 8.5e-32 AD Age of Onset Survival (IGAP) NG00058
upstream
19:45372867:G:A (rs387465)
 N/A A 1.1e-31 Transethnic LOAD: All Samples NG00056
upstream
19:45347911:C:A (rs4452060)
 A 1.3e-31 IGAP 2013: Stage 1 NG00036
upstream