CR1

complement component (3b/4b) receptor 1 (Knops blood group)

Also known as: C3BR, KN, C4BR, CD35

Genomic Context

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chr1, (207669473..207815110)

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Variant Effect Impact (snpEff)

  • High
  • Moderate
  • Low
  • Modifier
  • Not Reported

Functional Genomics within Gene Promoter Region

ChIP-Seq TFBS from ENCODE

SNPs within Expressed Enhancers Sites from FANTOM5

SNPs associated with FANTOM5 identified expressed enhancers proximal to the transcription start site of this gene (tissue independent). See methods for more information.

Explore additional functional genomics annotations within the CR1 gene (chr1:207669473-207815110).

Co-located SNPs

SNPs contained within the CR1 gene.

CR1 is identified by dbSNP as the closest gene to 4323 SNPs.

4214 SNPS are contained within the CR1 gene.

Of these, the following SNPs were found to have genome-wide significance in a NIAGADS dataset or the NHGRI GWAS Catalog

NIAGADS: Alzheimer's Disease

SNPs found to be significant with a p-value < 5 x 10-8 in a NIAGADS AD GWAS summary statistics dataset.

For exome array studies, a cutoff of p-value < 1 x 10-3 was used.

See methods for more information.

Select rows in the table below and then use the provided button to add selected variants to your basket.

Variant Mapped SNP p-Value Position Accession Resource
N/A
5.75e-24 chr1:207692049 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
3.02e-23 chr1:207806730 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
4.68e-23 chr1:207795320 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
6.17e-23 chr1:207786542 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
6.92e-23 chr1:207802552 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
1.07e-22 chr1:207685965 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
1.26e-22 chr1:207800555 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
2.75e-22 chr1:207786289 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
3.09e-22 chr1:207685786 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
3.39e-22 chr1:207784968 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
5.01e-22 chr1:207804141 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
1.02e-21 chr1:207798238 NG00036
IGAP 2013: Stages 1 and 2
summary statistics for IGAP (2013): stages 1 and 2, combined
N/A
3.63e-15 chr1:207747296 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
3.89e-15 chr1:207738077 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
4.07e-15 chr1:207750568 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
7.59e-15 chr1:207698044 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
7.76e-15 chr1:207692049 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
1.17e-14 chr1:207786828 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
1.86e-14 chr1:207799874 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.34e-14 chr1:207685786 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.57e-14 chr1:207806730 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.63e-14 chr1:207798716 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.63e-14 chr1:207786542 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.69e-14 chr1:207798238 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.82e-14 chr1:207800555 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
3.47e-14 chr1:207786289 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
3.55e-14 chr1:207685965 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
4.68e-14 chr1:207795320 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
4.90e-14 chr1:207796897 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
5.37e-14 chr1:207784968 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
7.24e-14 chr1:207802552 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
2.19e-13 chr1:207804141 NG00036
IGAP 2013: Stage 1
summary statistics for IGAP (2013): stage 1
N/A
3.39e-10 chr1:207692049 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
4.57e-10 chr1:207786289 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
4.79e-10 chr1:207784968 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
1.55e-09 chr1:207795320 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
1.55e-09 chr1:207800555 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
1.78e-09 chr1:207802552 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
3.09e-09 chr1:207804141 NG00027
ADGC 2011: Stages 1 and 2
summary statistics for ADGC (2011): stages 1 and 2, unadjusted
N/A
1.45e-08 chr1:207786289 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
N/A
1.48e-08 chr1:207784968 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
N/A
1.91e-08 chr1:207692049 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
N/A
3.31e-08 chr1:207692049 NG00027
ADGC 2011: Stages 1 and 2 Adjusted for Age, Sex and APOE
summary statistics for ADGC (2011): stages 1 and 2, adjusted for APOE, Age, and Sex
N/A
4.27e-08 chr1:207795320 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
N/A
4.27e-08 chr1:207800555 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted
N/A
4.68e-08 chr1:207802552 NG00027
ADGC 2011: Stage 1
summary statistics for ADGC (2011): stage 1, unadjusted

NIAGADS: Related Neuropathologies

NHGRI: Alzheimer's Disease

SNPs associated with the term Alzheimer's Disease in the NHGRI GWAS Catalog.

NHGRI: Other Traits

SNPs associated with the other traits in the NHGRI GWAS Catalog.

Functional Annotation

Gene Ontology

Functional annotations were obtained from NCBI Entrez Gene gene association files.

Click on a term accession number to view term details at the Gene Ontology Consortium.

Click on the number in the Find Similar column to get a list of genes annotated by the associated GO term.

GO Accession Term Evidence Code Ontology Find Similar
GO:0006958 complement activation, classical pathway IEA BP 51
GO:0002430 complement receptor mediated signaling pathway IDA BP 4
GO:0045087 innate immune response TAS BP 762
GO:0045957 negative regulation of complement activation, alternative pathway IDA BP 2
GO:0045959 negative regulation of complement activation, classical pathway IDA BP 4
GO:1900004 negative regulation of serine-type endopeptidase activity IDA BP 4
GO:1900005 positive regulation of serine-type endopeptidase activity IDA BP 1
GO:0030449 regulation of complement activation TAS BP 26
GO:0009986 cell surface IDA CC 493
GO:0070062 extracellular exosome IDA CC 2758
GO:0005887 integral component of plasma membrane IDA CC 1278
GO:0005886 plasma membrane TAS CC 3784
GO:0001851 complement component C3b binding IDA MF 2
GO:0004877 complement component C3b receptor activity IDA MF 1
GO:0001855 complement component C4b binding IDA MF 2
GO:0001861 complement component C4b receptor activity IDA MF 1

KEGG Pathways

Click on a pathway accession number to view term details at KEGG.

Click on the number in the Find Similar column to get a list of genes annotated by the associated pathway.

KEGG Accession Pathway Find Similar
hsa04610 Complement and coagulation cascades 58
hsa04640 Hematopoietic cell lineage 66
hsa05134 Legionellosis 43
hsa05140 Leishmaniasis 40
hsa05144 Malaria 35
hsa05152 Tuberculosis 97